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Collagen membrane and preparation method thereof

A collagen film and collagen technology, applied in the field of collagen film and its preparation, can solve the problem of single efficacy of collagen film, achieve good therapeutic effect, prolong storage time, and accelerate regeneration

Active Publication Date: 2015-10-21
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Compared with films formed by chemically synthesized materials such as polyurethane films and silicone rubber films, collagen films can be better attached to the skin and have good compatibility, but the existing collagen films have only a single effect

Method used

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  • Collagen membrane and preparation method thereof
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preparation example Construction

[0028] The present invention also provides a preparation method of the above-mentioned collagen film, comprising: mixing collagen, patchouli oil and glacial acetic acid aqueous solution, then adjusting the pH value to 5-6, gelling, cross-linking and drying at low temperature, Obtain a collagen film.

[0029] Wherein said collagen, patchouli oil and glacial acetic acid are all the same as above, and will not be repeated here.

[0030] According to the present invention, preferably first collagen is mixed with glacial acetic acid aqueous solution; The concentration of described glacial acetic acid aqueous solution is preferably 0.05~0.1mol / L; The pH value of described glacial acetic acid aqueous solution is preferably 3.2~4.5; The temperature of described mixing Preferably it is 4°C to 10°C, more preferably 4°C to 8°C. Mixing at this temperature can well protect the collagen triple helix structure. After mixing, it is preferable to stir at a uniform speed until completely diss...

Embodiment 1

[0043] 1.1 Add collagen to glacial acetic acid solution (pH3.2) with a concentration of 0.05mol / L and mix, control the temperature at 4°C, stir at a constant speed until the solution is complete, and obtain a collagen-acetic acid solution with a collagen mass concentration of 2.5% .

[0044] 1.2 Based on the collagen-acetic acid solution, add 0.05ml / L patchouli oil, 0.15ml / L litsea cubeba oil, 5ml / L turmeric volatile oil, and 0.2ml / L long Torreya volatile oil, 0.2ml / L volatile oil of bay leaf and 6ml / L garlic volatile oil to obtain Chinese medicine collagen solution.

[0045] 1.3 Add phenol red solution to the traditional Chinese medicine collagen solution obtained in 1.2, and adjust the pH value of the solution to 5.0.

[0046] 1.4 Gel: Put the solution obtained in 1.3 into a gel mold and gel at 4°C for 2 hours to obtain a collagen film.

[0047] 1.5 Crosslinking: put the collagen membrane obtained in 1.4 into 0.01mol / L EDC crosslinking agent for crosslinking for 10h, take ...

Embodiment 2

[0051] 2.1 Add collagen to glacial acetic acid solution (pH4.0) with a concentration of 0.5mol / L and mix, control the temperature at 4°C, stir at a constant speed until the solution is complete, and obtain a collagen-acetic acid solution with a collagen mass concentration of 3%. .

[0052] 2.2 Based on the collagen-acetic acid solution, add 0.5ml / L patchouli oil, 0.25ml / L litsea cubeba oil, 6ml / L turmeric volatile oil, and 0.25ml / L long Torreya volatile oil, 0.3ml / L volatile oil of bay leaf and 9ml / L garlic volatile oil to obtain Chinese medicine collagen solution.

[0053] 2.3 Add phenol red solution to the traditional Chinese medicine collagen solution obtained in 2.2, and adjust the pH value of the solution to 5.8.

[0054] 2.4 Gel: Put the solution obtained in 2.3 into a gel mold and gel at 4°C for 3 hours to obtain a collagen film.

[0055] 2.5 Crosslinking: put the collagen membrane obtained in 2.4 into 0.03mol / L EDC crosslinking agent for crosslinking for 10h, take ou...

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Abstract

The invention provides a collagen membrane and a preparation method thereof. The collagen membrane comprises collagen, patchouli oil, glacial acetic acid and water. Compared with the prior art, the collagen membrane utilizes the characteristic that the collagen can be dissolved when being heated, the collagen membrane can be attached to the surface of a wound more tightly, the collagen membrane has a transdermal absorption effect, the patchouli oil can reach a skin basal layer faster, regeneration of cells of the surface of the wound can be accelerated, healing of the wound can be promoted, the collagen membrane has good treatment function on dermatophytes and conditional fungi at the same time, and the bacteriostasis function also prolongs the storage time of the collagen membrane.

Description

technical field [0001] The invention belongs to the field of patch technology, and in particular relates to a collagen film and a preparation method thereof. Background technique [0002] Collagen is abundant in animals, especially in mammals, accounting for about 20% to 30% of its total protein. It mainly exists in animal skin, cartilage, ligaments, tendons and other connective tissues to support and protect it. , is an important structural protein of connective tissue. Since most of the leather resources in our country are used in the form of tanning, the utilization rate is extremely low, and if the leather solid waste produced is not recycled, it will not only occupy the site, pollute the environment, but also damage the collagen resources. Great waste. In the past 20 years, with the development of molecular biology, people's understanding of the properties of collagen has become more and more in-depth, and its application fields have become more extensive. [0003] C...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/42A61K36/53A61K36/9066A61K36/54A61P17/02A61P31/10A61K31/19
Inventor 陈海佳王一飞葛啸虎李丽娟李平
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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