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Peripheral nerve repairing film and preparation method thereof

A peripheral nerve and chitosan technology, applied in medical science, prosthesis, etc., can solve the problems of low cure rate, low success rate, complicated operation and other problems of patients, and achieve high cure rate, low production cost and convenient use Effect

Inactive Publication Date: 2015-10-21
SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above treatment methods are complicated to operate, and the success rate is low, so the patient's cure rate is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A peripheral nerve repair membrane, mainly made of the following raw materials according to the ratio of parts by mass: 13 parts of chitosan, 12 parts of collagen, 13 parts of hyaluronic acid, 12 parts of chitin, 10 parts of trehalose, and 8 parts of gelatin 2 parts, 2 parts of cellulose acetate, 13 parts of ethylene glycol, 13 parts of acetic acid, 5 parts of calcium polyphosphate, 25 parts of double distilled water.

[0028] A preparation method for a peripheral nerve repair membrane, comprising the following steps:

[0029] (1) Dissolve acetic acid in double distilled water to prepare an acetic acid solution with a mass concentration of 0.05%, and dissolve chitosan, collagen, hyaluronic acid and chitin in acetic acid at a mass ratio of 1:5:0.5:3 In the solution, stir and mix evenly to obtain the base liquid;

[0030] (2) Put cellulose acetate and calcium polyphosphate in a reaction kettle, make a melt at a temperature of 630°C and a pressure of 2.2MPa, dry and pulve...

Embodiment 2

[0035] A peripheral nerve repair membrane, mainly made of the following raw materials according to the ratio of parts by mass: 24 parts of chitosan, 22 parts of collagen, 21 parts of hyaluronic acid, 25 parts of chitin, 18 parts of trehalose, and 14 parts of gelatin 9 parts of cellulose acetate, 17 parts of ethylene glycol, 13-28 parts of acetic acid, 7 parts of calcium polyphosphate, and 48 parts of double distilled water.

[0036] A preparation method for a peripheral nerve repair membrane, comprising the following steps:

[0037] (1) Dissolve acetic acid in double distilled water to prepare an acetic acid solution with a mass concentration of 0.15%, and dissolve chitosan, collagen, hyaluronic acid and chitin in acetic acid at a mass ratio of 1:6:1:7 In the solution, stir and mix evenly to obtain the base liquid;

[0038] (2) Put cellulose acetate and calcium polyphosphate in a reaction kettle, make a melt under the conditions of temperature 790°C and pressure 3.7MPa, and d...

Embodiment 3

[0043] A peripheral nerve repair membrane, mainly made of the following raw materials according to the ratio of parts by mass: 30 parts of chitosan, 28 parts of collagen, 26 parts of hyaluronic acid, 30 parts of chitin, 22 parts of trehalose, 19 parts of gelatin 13 parts of cellulose acetate, 23 parts of ethylene glycol, 28 parts of acetic acid, 9 parts of calcium polyphosphate, 58 parts of double distilled water.

[0044] A preparation method for a peripheral nerve repair membrane, comprising the following steps:

[0045] (1) Dissolve acetic acid in double distilled water to prepare an acetic acid solution with a mass concentration of 0.3%, and dissolve chitosan, collagen, hyaluronic acid and chitin in acetic acid at a mass ratio of 3:9:3:9 In the solution, stir and mix evenly to obtain the base liquid;

[0046] (2) Put cellulose acetate and calcium polyphosphate in a reaction kettle, make a melt at a temperature of 820°C and a pressure of 4.1MPa, and dry and pulverize it in...

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Abstract

The invention discloses a peripheral nerve repairing film and a preparation method thereof. The peripheral nerve repairing film mainly comprises the following raw materials by mass: 13 to 30 parts of chitosan, 12 to 28 parts of collagen, 13 to 26 parts of hyaluronic acid, 12 to 30 parts of chitin, 10 to 22 parts of trehalose, 8 to 19 parts of gelatin, 2 to 13 parts of cellulose acetate, 13 to 23 parts of ethylene glycol, 13 to 28 parts of acetic acid, 5 to 9 parts of calcium polyphosphate, and 25 to 58 parts of double distilled water. Compared with the prior art, the peripheral nerve repairing film and the preparation method have the advantages that: (1) injured parts of a peripheral nerve can be repaired effectively with the peripheral nerve repairing film, so as to improve the cure rate of peripheral nerve injury; (2) the peripheral nerve repairing film prepared according to the preparation method is safe, nontoxic, convenient to use and low in preparation cost; (3) the peripheral nerve repairing film can be degraded naturally by a human body, and no negative side effect is caused.

Description

technical field [0001] The invention relates to the field of new materials for bioengineering, in particular to a peripheral nerve repair membrane and a preparation method thereof. Background technique [0002] With the development of society and the progress of science, the mutual embedding and infiltration among disciplines have been caused. Biomedical materials science, produced by the interpenetration and development of modern life sciences, materials science, medicine, engineering and other disciplines, has attracted more and more attention with the improvement of people's health and quality of life standards, and has become A hotspot of competing research and development. Biomedical materials, also known as biomaterials, refer to new inanimate high-tech materials that are used for medical purposes to diagnose, treat, repair or replace damaged tissues and organs or enhance their functions. Biomaterials include tissue engineering materials, nano-biomaterials, biominera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/20A61L27/18A61L27/50A61L27/58
Inventor 凌云金可心夏戊君凌天阳
Owner SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH
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