Heparan polyethersulfone hollow fiber membrane and preparation method and applications thereof

A technology of heparinization and polyethersulfone is applied in the field of heparin-like polyethersulfone hollow fiber membrane and its preparation, which can solve the problem of membrane structure, poor performance stability, reduced membrane strength and mechanical properties, and reduced membrane filtration stability. It can achieve the effect of stable anticoagulation ability, uniform structure and low cost

Active Publication Date: 2015-11-04
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although this method is simple in process, easy to operate, and low in cost, the modification of the polyethersulfone hollow fiber membrane by directly blending the hydrophilic polymer additive with polyethersulfone will cause the hollow fiber membrane to become hydrophilic during use. Additives will slowly precipitate, so the structure and performance of the film prepared by this method are not stable (Journal of Polymer Science Part B: Polymer Physics, 2006,44(10):1490)
Although the use of amphiphilic heparan-like polymers can solve the problem of additive precipitation (Macromolecular Bioscience, 2012, 12:116–125), there is always a large phase separation problem between the addition of polymers and the polyethersulfone membrane, which is easy to Reduce the strength and mechanical properties of the membrane, thereby reducing the filtration stability of the membrane, limiting its further application in industrial production

Method used

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  • Heparan polyethersulfone hollow fiber membrane and preparation method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Put 10 parts of polyethersulfone and 90 parts of N,N-dimethylacetamide into a reaction kettle equipped with a stirrer, thermometer and heater, and dissolve completely at a temperature of about 70°C under stirring. 2 parts of SSNa were added, the amount of N,N'-methylenebisacrylamide was 1% of the mole fraction of the reaction monomers, and the amount of azobisisobutyronitrile was 1% of the mole fraction of the reaction monomers. After gradually adding under stirring, react at a temperature of about 80°C for about 12 hours to obtain a modified polyethersulfone solution. After filtering and defoaming, it is left to "cure" to obtain a polyethersulfone spinning raw solution.

[0028] Press-filter the polyethersulfone spinning solution, and extrude it through two concentric hollow fiber spinnerets with a metering pump. The extrusion speed of the spinning solution is 7ml / min; Solidify and form in a water bath at 35°C; then stretch and wind in a plasticizing bath at a speed o...

Embodiment 2

[0030] Put 25 parts of polyethersulfone and 75 parts of N,N-dimethylacetamide into a reaction kettle equipped with a stirrer, thermometer and heater, and dissolve completely at a temperature of about 80°C under stirring. 2 parts of MAANa were added, the amount of N, N'-methylenebisacrylamide was 1% of the mole fraction of the reaction monomers, and the amount of azobisisobutyronitrile was 1% of the mole fraction of the reaction monomers. After gradually adding under stirring, react at a temperature of about 90°C for about 12 hours to obtain a modified polyethersulfone solution. After filtering and defoaming, place it for "aging" to obtain a polyethersulfone spinning solution.

[0031] Press-filter the polyethersulfone spinning solution, and extrude it through two concentric hollow fiber spinnerets with a metering pump. The extrusion speed of the spinning solution is 7ml / min; Solidify and form in a water bath at 30°C; then stretch and wind in a plasticizing bath at a speed of ...

Embodiment 3

[0033] Put 15 parts of polyethersulfone and 85 parts of N,N-dimethylformamide into a reaction kettle equipped with a stirrer, thermometer and heater, and dissolve completely at a temperature of about 70°C under stirring. 2 parts of SSNa and 1 part of MAANa were added, the amount of N,N'-methylenebisacrylamide added was 1% of the mole fraction of the reaction monomers, and the amount of dibenzoyl peroxide added was 1% of the mole fraction of the reaction monomers. After gradually adding under stirring, react at a temperature of about 80°C for about 12 hours to obtain a modified polyethersulfone solution. After filtering and defoaming, place it for "aging" to obtain a polyethersulfone spinning solution.

[0034] Press-filter the polyethersulfone spinning solution, and extrude it through two concentric hollow fiber spinnerets with a metering pump. The extrusion speed of the spinning solution is 7ml / min; Solidify and form in a water bath at 35°C; then stretch and wind in a plasti...

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Abstract

The present invention discloses a heparan polyethersulfone hollow fiber membrane and a preparation method and applications thereof. The material components of the hollow fiber membrane comprise polyethersulfone used as a matrix component and a heparan modified component, the structure of the membrane material is a semi-interpenetrating network structure of the heparan modified component and the matrix component, the heparan modified component is selected from sodium p-styrenesulfonate and sodium methacrylate, and the number-average molecular weight of the polyethersulfone is 20000-60000. The preparation method for the hollow fiber membrane comprises: dissolving polyethersulfone in a solvent, then adding a heparan modified component, and performing dissolving thoroughly to prepare a spinning solution; the spinning solution being extruded through two concentric round spinneret holes by a pump, and entering into a water bath with a temperature of 20-50 DEG C for a solidification and shaping to obtain a hollow fiber membrane; and placing the hollow fiber membrane in water with a temperature of 50-60 DEG C for soaking and boiling so as to remove the residual solvent on the hollow fiber membrane. The polyethersulfone hollow fiber membrane provided by the present invention is greatly improved in hydrophilicity, contamination resistance, and self-anticoagulation.

Description

1. Technical field [0001] The invention relates to the field of functional polymer hollow fiber membrane materials, in particular to a heparin-like polyethersulfone hollow fiber membrane with anti-protein pollution and self-anticoagulant properties, as well as its preparation method and application. 2. Background technology [0002] Polyethersulfone (PES for short) material is a special engineering plastic that was first successfully developed and commercialized by the British ICI company in 1972. PES has excellent heat resistance, physical and mechanical properties, insulation properties and good biocompatibility, etc., so it has been widely used in many fields. Its thermal deformation temperature is 200-220°C, and it has good resistance to steam and superheated water (150-160°C). Good chemical resistance, stable to general acids, alkalis, aliphatic hydrocarbons, oils, alcohols, etc. Polyethersulfone also has good film-forming properties and filtration properties, thus ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/08B01D67/00A61M1/18A61M1/34
Inventor 赵长生聂川雄程冲李双四马朗
Owner SICHUAN UNIV
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