Application of substituted benzene guanidine derivative serving as polymyxins antibiotic potentiator

A polymyxin and derivative technology, applied in the field of biomedicine, can solve problems such as environmental pollution and the impact of the application of polymyxin antibiotics, and achieve a significant effect of drug resistance reversal
CN105030744AActive Publication Date: 2015-11-11GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
Publication Date
2015-11-11

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Abstract

The invention discloses application of a substituted benzene guanidine derivative serving as a polymyxins antibiotic potentiator. For the first time, the substituted benzene guanidine derivative is found to be capable of serving as the polymyxins antibiotic potentiator, especially serving as a synergist of a polymyxins antibiotic to inhibit sensitive strains and a drug resistance reversal agent of the polymyxins antibiotic. The invention further provides combined application of the substituted benzene guanidine derivative or a combination containing the same and the polymyxins antibiotic in preparation of compound drug preparations for people or animals to treat diseases caused by gram-negative bacterial infection. The invention further provides combined application of the substituted benzene guanidine derivative or a combination containing the same and the polymyxins antibiotic in preparation of forage-use growth-promoting feed additives for animal breeding in animal husbandry.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to the application of substituted benzoguanidine derivatives as polymyxin antibiotic synergists. Background technique

[0002] The chemical synthesis and biological application research of diaminoguanidine, especially substituted benzoguanidine derivatives, started very early, and the main research results are as follows: US4310541A discloses substituted benzoguanidine derivatives for the treatment of trichomoniasis and anti-parasites in humans; US4575560A provides The substituted benzoguanidine derivatives are applied in the direction of agricultural production, and have antifeedant activity and control squamous insects to protect crops; the substituted benzoguanidine derivatives provided by US3992446 are used as anti-protozoal drugs, especially anticoccidial drugs; WO2014176636A1 provides a series of Substituted phenylguanidine derivatives are used in the treatment of bacter...

Claims

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