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A method for identifying nitrofurazone and furazolidone in cockles by using electronic nose

A technology of furazolidone and nitrofurazone, which is applied in the direction of material resistance, can solve the problems of complex detection and long identification time, and achieve good identification effect, less identification time and obvious identification results

Active Publication Date: 2017-10-31
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the detection of furan compounds in environmental or biological samples generally adopts chemical extraction methods such as supercritical fluid extraction (SFE), microwave-assisted extraction (MAE), accelerated solvent extraction (ASE), and solid-phase microextraction (SPME). Then use gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS) or ELISA methods for detection; extraction and detection are performed separately, the detection is complicated and the identification time is long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Using an electronic nose to identify nitrofurazone and furazolidone in cockles, remove the hard shell of cockles, cut up the soft part, take 1g, put it into a 15ml sampling bottle, and test it in 5 different places of origin (2 farms in Qidong, Jiangsu) , 3 breeding farms in Fenghua, Zhejiang) in a parallel test of cockles, the soft cap of the bottle mouth was sealed, and the bottle cap was tightened, and a blank sample bottle was tested at the same time. Each sample vial was heated and kept in a constant temperature water bath at 60°C for 30 min, and cooled at room temperature for 15 min to balance the headspace gas in the vial, and then detected with a model PEN 3 electronic nose (Airsense, Mecklenburg, Germany). Turn on the sensor of the electronic nose of model PEN 3 (array 1-10), preheat for 30 minutes, insert the sampling needle of the sensor into the soft cap of the sampling bottle, the distance between the needle of the sampling needle and the opening of the bott...

Embodiment 2

[0013] Preparation of standard solution: furazolidone group: concentration 0.1μg / L, 1μg / L, 10μg / L, nitrofurazone group: concentration 0.1μg / L, 1μg / L, 10μg / L, blank group; then take 1 mL into 15ml injection The vials and injection vials were heated in a constant temperature water bath at 60°C for 30 minutes, cooled at room temperature for 15 minutes, and the sensor (array 1-10) of the electronic nose of model PEN 3 was turned on, preheated for 30 minutes, and the sampling needle of the sensor was inserted into the In the soft cap of the sampling bottle, the distance between the needle of the sampling needle and the mouth of the bottle is 1 / 3 of the height of the bottle. The distance between the needle of the injection needle and the mouth of the bottle is 1mm, and then the array parameters of the sensor are set for detection: the headspace generation time is 600s, the oscillation speed is 500r / min, the total signal acquisition time is 100s, the signal frequency is 1.0s, and the ...

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Abstract

The invention discloses a method for identifying nitrofurazone and furazolidone in cockles by using an electronic nose. The soft tissue of the cockles is heated at a temperature of 60°C in a sampling bottle, and the nitrofurazone and furazolidone are volatilized, and then the sensor of the electronic nose of the model PEN 3 is set appropriately array parameters, and then the electronic nose automatic pattern recognition system obtains the conductivity ratio of the sensor, if the conductivity ratio parameter of the No. 2 sensor is greater than 2.0, then the soft tissue of the clam contains furazolidone; ~0.71, the cockle soft tissue contains nitrofurazone; in this way, using an electronic nose to identify nitrofurazone and furazolidone in cockles, the detection method is simple, does not require extraction, and does not require graphic analysis and comparison. The identification results are obvious, the identification effect is good, and the identification time is short The advantages.

Description

technical field [0001] The invention relates to the identification of nitrofurazone and furazolidone, in particular to a method for identifying nitrofurazone and furazolidone in cockles by using an electronic nose. Background technique [0002] Furacilin (fμgracilin) ​​is a synthetic antibacterial drug that can treat animal diseases. Furazolidone (former name: Furazolidone) is a nitrofuran antibiotic. Furazolidone is a broad-spectrum antibacterial drug that can inhibit common Gram-negative bacteria and positive bacteria. Furacillin and furazolidone are commonly used furan compounds, which belong to persistent organic pollutants (Persistent Organic Pollutants, referred to as POPs), have a long half-life, and can accumulate through food webs, and can persist in the environment for a long time, which is harmful to human health The threat will exist for a long time. At present, the detection of furan compounds in environmental or biological samples generally adopts chemical ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/04
Inventor 苏秀榕王祖忠周君李晔张春丹张迪骏李太武
Owner NINGBO UNIV
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