A traditional Chinese medicine enteric-coated capsule for middle and advanced tumors and chronic hepatitis B and its preparation method
A technology of enteric-coated capsules and chronic hepatitis B, which is applied in the direction of anti-tumor drugs, capsule delivery, drug combination, etc., and can solve problems such as unsatisfactory extraction methods, unsatisfactory curative effect, side effects, etc.
Active Publication Date: 2017-07-28
陕西东泰制药有限公司
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Problems solved by technology
The inventor found through long-term research on dry toad skin: although the above two processes have obtained more indole alkaloids and bufolides than the prior art, the extraction method is not very ideal, and the curative effect needs to be improved , and patients have some side effects after long-term use
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[0094] 1. Take 3500g of dried toad skin, chop it, pass it through a 24-mesh sieve, wash it, add 70% ethanol and soak it for 48 hours, carry out percolation at a speed of 5ml / min, collect 6 times the amount of percolation liquid, and at -0.08Mpa Under the condition of 60-70 ℃, ethanol is recovered under reduced pressure until there is no alcohol smell, and the clear ointment is obtained for later use; take the dregs after percolation, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 45 minutes, and decoct for the second time Add 6 times the amount of water each time, decoct for 30 minutes, combine the decoction, filter, and centrifuge the filtrate at a speed of 4000r / min for 30min, take the supernatant and concentrate it to a clear paste with a relative density of 1.08-1.10, and combine it with the above clear paste, Spray-dry it into a fine powder to obtain the active ingredient of the drug, and then mix it with 50 g of sodium carboxymet...
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The invention discloses a Chinese medicinal enteric-coated capsule for middle and advanced stage tumors and chronic hepatitis B and a preparation method thereof. The Chinese medicinal enteric-coated capsule is prepared by processing of drug active component processed from dried toad skin and a pharmaceutical acceptable carrier according to certain proportion. The pharmaceutical acceptable carrier consists of carboxymethylcellulose sodium and starch. Compared with the prior art, the Chinese medicinal enteric-coated capsule provided by the invention adopts 70% ethanol for percolation extraction, the content of the effective components of indole alkaloids and bufogenin is enhanced, the curative effect is strengthened, the toxic and side effects of the drug are reduced, the drug can achieve significant curative effect after taking by patients, and is safer and more convenient.
Description
technical field [0001] The invention relates to a traditional Chinese medicine enteric-coated capsule for middle-advanced tumors and chronic hepatitis B and a preparation method thereof, belonging to the technical field of pharmacy. [0002] technical background [0003] The fat-soluble components bufolides in dried toad skin have significant anti-tumor effects; the water-soluble components indole alkaloids in dried toad skin can regulate immunity, inhibit the replication of HBV and DNA, and have strong antiviral effects , has a good therapeutic effect on hepatitis B. Prior art: 1. On January 14, 2009, the Chinese Patent Gazette disclosed a patent application declared by the applicant as "a traditional Chinese medicine preparation for treating middle-advanced tumors and chronic hepatitis B and its preparation method", and the publication number is CN101342194A According to the invention, the preparation method of the traditional Chinese medicine preparation is mainly as foll...
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IPC IPC(8): A61K35/65A61K9/48A61P35/00A61P31/20
Inventor 罗川
Owner 陕西东泰制药有限公司