Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for improving stability of salvianolic acid B

A salvianolic acid and stability technology, applied in the field of improving the stability of salvianolic acid B, can solve problems such as potential safety hazards and restrictions on the application of salvianolic acid B oral liquid preparations, and achieve low production costs, good thermal stability and chemical stability. Stability, the effect of improving stability

Inactive Publication Date: 2015-11-18
SHANXI UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the instability of salvianolic acid B not only makes it a safety hazard in clinical application, but also limits the application of salvianolic acid B oral liquid preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for improving stability of salvianolic acid B
  • Method for improving stability of salvianolic acid B

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Mix the dried propylene glycol and choline chloride at a molar ratio of 2:1, heat and stir at 100°C for 6 hours to obtain a uniform transparent liquid, i.e. eutectic mixture; accurately weigh 2.13 mg of salvianolic acid B solution In 0.5ml eutectic mixture, seal the mixed solution, place it in a constant temperature water bath at 60°C and heat it. Samples were taken at 0, 3, 6, 9, and 12 hours, cooled rapidly, and the degradation rate of salvianolic acid B was determined to be 0.0273.

Embodiment 2

[0023] Mix the dried glycerol and choline chloride in a molar ratio of 4:1, heat and stir at 90°C for 8 hours to obtain a uniform and transparent liquid, i.e. eutectic mixture; accurately weigh salvianolic acid B1. 68mg was dissolved in 0.5ml eutectic mixture, the mixed solution was sealed and heated in a constant temperature water bath at 90°C. Samples were taken at 0, 3, 6, 9, and 12 hours, cooled rapidly, and the degradation rate of salvianolic acid B was determined to be 0.1027. The salvianolic acid B was dissolved in pure water and operated in parallel, and the degradation rate of salvianolic acid B was determined to be 0.2083. The chromatogram of salvianolic acid B and its degradation products is shown in figure 1 .

Embodiment 3

[0025] Mix the dried butanediol and choline chloride in a molar ratio of 2:1, heat and stir at 90°C for 10 hours to obtain a uniform transparent liquid, i.e. eutectic mixture; accurately weigh salvianolic acid B1. 47mg was dissolved in 0.5ml eutectic mixture, the mixed solution was sealed, and heated in a constant temperature water bath at 90°C. Samples were taken at 0, 3, 6, 9, and 12 hours, cooled rapidly, and the degradation rate of salvianolic acid B was determined to be 0.1674. The salvianolic acid B was dissolved in pure water and operated in parallel, and the degradation rate of salvianolic acid B was determined to be 0.2083.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a method for improving stability of salvianolic acid B. The method comprises the steps of: 1) preparing a low eutectic mixture, mixing dried polyol with choline quaternary ammonium salt in a molar ratio of 4-1:1, and heating with stirring at 80-100 DEG C for 6-10 h to obtain a uniform transparent liquid; 2) weighing and dissolving salvianolic acid B in the eutectic mixture, sealing and storing. The salvianolic acid B has good thermal stability (60-90 DEG C) in the eutectic mixture. The present invention overcomes the disadvantages of easy deterioration and degradation of salvianolic acid B during storage in a conventional solvent and high-temperature sterilization, and has great importance on the development and application of salvianolic acid B oral preparations.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a method for improving the stability of salvianolic acid B. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge. According to the "Pharmacopoeia of the People's Republic of China", Danshen has the functions of promoting blood circulation and removing blood stasis, dredging menstrual flow and relieving pain, clearing the heart and eliminating troubles, cooling blood and eliminating carbuncles. The medicinal ingredients of Danshen can be mainly divided into fat-soluble ingredients and water-soluble ingredients. Since the traditional use of Danshen is mostly taken by decoction, the medicinal ingredients are mainly water-soluble ingredients. However, the water-soluble components in Salvia miltiorrhiza are mainly phenolic acid compounds, among which salvianolic acid B is the phenolic acid component with...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D307/86
CPCC07D307/86
Inventor 陈珏张立伟
Owner SHANXI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com