Application of triterpenoid in preventing or treating hyperlipidemia

A technology for hyperlipidemia and composition, which is applied in the direction of medical preparations containing active ingredients, applications, food science, etc., and can solve problems such as reports on the therapeutic effect of betulinic acid that have not been seen.
CN105079002AInactive Publication Date: 2015-11-25CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2015-11-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an application of epibetulinic acid in preventing or treating hyperlipidemia. According to the invention, epibetulinic acid which is commercially available or is prepared by the existing method, or pharmaceutical salts, aquo-complexes or anhydrides of epibetulinic acid are adopted, the epibetulinic acid is prepared into medicines, health products or functional foods, and excipients or carriers common in the pharmacy or the food field, such as diluents, disintegrating agents, and lubricating agents, are adopted. In the application, the epibetulinic acid is administered to LO2 cells, and after 24h, the contents of triglyceride and cholesterol are detected; the result shows that the epibetulinic acid has obvious effects in reducing cholesterol and triglyceride, and obvious statistical differences and good dose-effect relationship are also obtained.
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Description

technical field

[0001] The invention relates to the field of natural medicines, and relates to the use of betulinic acid to prevent or treat hyperlipidemia. Background technique

[0002] Hyperlipidemia refers to excessive blood lipid levels, a metabolic disease in which one or more lipids in plasma are higher than normal due to abnormal fat metabolism or operation. Mainly include elevated triglycerides and cholesterol Elevated biliary triglycerides. The increase of blood lipid level will make the incidence of cardiovascular disease and mortality increase with the increase of serum total cholesterol and LDL cholesterol level. In addition, elevated triglycerides and cholesterol are also closely related to atherosclerosis, non-alcoholic fat, and type II diabetes. Therefore, it is of great clinical significance to develop good drugs for the treatment of hyperlipidemia. The liver is the main organ of lipid metabolism, so normal liver cells LO2 and liver cancer cells HepG2 are ...

Claims

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