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Anionic polymer brush based on hyaluronic acid and preparation method and application thereof

An anionic polymer and hyaluronic acid technology, applied in the field of biomedicine, can solve problems such as insufficient frictional mechanical properties of joint prosthesis cartilage restorations, practical application limitations, insufficient osteoarthritis drugs, etc., to achieve easy purification, convenient operation, Improve the effect of friction and wear

Active Publication Date: 2017-06-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Many achievements have been made in the field of biomimetic lubrication, but most of the research is to anchor the polymer on a certain substrate by surface grafting to study its friction and lubrication performance, thus forming many restrictions on its practical application. Insufficient drugs for osteoarthritis, insufficient frictional mechanical properties of joint prostheses and cartilage restorations

Method used

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  • Anionic polymer brush based on hyaluronic acid and preparation method and application thereof
  • Anionic polymer brush based on hyaluronic acid and preparation method and application thereof
  • Anionic polymer brush based on hyaluronic acid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation of anionic polymer brushes based on hyaluronic acid and 2-acrylamide-2-methylpropanesulfonic acid

[0037] For a schematic diagram of the synthetic route, see figure 1 .

[0038] (1) Dissolve 100 mg of hyaluronic acid with a molecular weight of 1 to 1.5 million in 20 mL of deionized water, stir to dissolve, add 1.736 g of adipate dihydrazide and hyaluronic acid solution, mix adipate dihydrazide and hyaluronic acid The mass ratio of the solution is 17.36:1, the pH value of the solution is adjusted to 4.75 with 1mol / L hydrochloric acid, and 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC ) 0.191g, continue to adjust the pH value of the solution to 4.75, react at 30°C until the pH value remains unchanged, dialyze and freeze-dry to obtain amino-modified hyaluronic acid;

[0039] (2) Dissolve 33.2g of 2-acrylamide-2-methylpropanesulfonic acid (AMPS) in 80mL of deionized water, neutralize the sodium hydroxide solution to about pH=6.5, and weigh 2...

Embodiment 2

[0041] Example 2: Preparation of anionic polymer brushes based on hyaluronic acid and 2-acrylamide-2-methylpropanesulfonic acid

[0042] (1) Dissolve 100 mg of hyaluronic acid with a molecular weight of 1 million to 1.5 million in 20 mL of deionized water, stir to dissolve, add 435.4 mg of adipate dihydrazide and hyaluronic acid solution, mix adipate dihydrazide and hyaluronic acid The mass ratio is 4.35:1. The pH value of the solution was adjusted to 4.8 with 1mol / L hydrochloric acid, and 30 mg of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) was added in solid form, and the pH value of the solution was continued to increase. Adjust to 4.8, react at 30°C until the pH value remains unchanged, dialyze and freeze-dry to obtain amino-modified hyaluronic acid.

[0043] (2) Dissolve 16.56g of 2-acrylamide-2-methylpropanesulfonic acid (AMPS) in 40mL of deionized water, neutralize the sodium hydroxide solution to about pH=6.5, and weigh 11.2mg of 4,4'- Azo (4-cyanovaleric aci...

Embodiment 3

[0045] Example 3: Preparation of anionic polymer brushes based on hyaluronic acid and 2-acrylamide-2-methylpropanesulfonic acid

[0046] (1) Dissolve 100 mg of hyaluronic acid with a molecular weight of 1 million to 1.5 million in 20 mL of deionized water, stir to dissolve, add 868 mg of adipate dihydrazide and hyaluronic acid solution, mix the adipate dihydrazide and hyaluronic acid The mass ratio is 8.68:1. The pH value of the solution was adjusted to 4.8 with 1mol / L hydrochloric acid, and 60 mg of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) was added in solid form, and the pH value of the solution was continued to be adjusted to 4.8. Adjust to 4.8, react at 30°C until the pH value remains unchanged, dialyze and freeze-dry to obtain amino-modified hyaluronic acid.

[0047] (2) Dissolve 16.56g of 2-acrylamide-2-methylpropanesulfonic acid (AMPS) in 40mL of deionized water, neutralize the sodium hydroxide solution to about pH=6.5, and weigh 11.2mg of 4,4'- Azo (4-cy...

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Abstract

The invention belongs to the technical field of biological medicine, and discloses an anionic polymer brush based on hyaluronic acid, a preparation method of the anionic polymer brush and application of the anionic polymer brush in the field of biological medicine. The anionic polymer brush is particularly suitable for being used for preparing medicine for treating osteoarthritis and lubricating agents for improving the prosthesis lubricating performance, and the anionic polymer brush can be combined with cartilage restoring materials to improve the friction mechanical property. The polymer brush has the following structure shown as the accompanying drawing, wherein n is an integer from 200 to 300; x is an integer from 280 to 427, and y is an integer from 90 to 150. The preparation method of the anionic polymer brush based on hyaluronic acid and 2-acrylamide-2-methyl propane sulfonic acid has the advantages that the route is simple; the operation is convenient; the purification is easy; the yield is higher, and the like. The anionic polymer brush can be used for preparing medicine for treating arthritis, and can be used as bionic lubricants for alleviating the friction abrasion.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a hyaluronic acid-based anionic polymer brush and its preparation method and application in the field of biomedicine, and is especially suitable for preparing medicine for treating osteoarthritis and improving prosthetic lubrication and friction performance lubricants, and can be combined with cartilage repair materials to improve their tribological properties. Background technique [0002] Articular cartilage has extremely low friction and wear under complex and variable loads and physiological conditions, and its friction coefficient is generally as low as 10 -3 , even 10 -4 . This level of friction is currently beyond the reach of human technology. A series of studies on articular cartilage and synovial fluid have been carried out since the 1950's in order to put this level of friction and wear into practical use. The results show that the reason for the ul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F220/58C08F2/38C08F4/04A61K31/728A61P19/02A61L27/50
Inventor 刘卅任力谢仁箭王琳
Owner SOUTH CHINA UNIV OF TECH
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