Degradable ultrafine needle piece
A needle-shaped and ultra-fine technology, which is applied in the direction of drug devices and other medical devices, can solve problems such as discount of cosmetic liquid penetration effect, dermatitis, infectious diseases, etc., and achieve good aging precipitation strengthening and solid solution strengthening effect. , The effect of improving electrode potential and low corrosion potential
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Embodiment 1
[0017] Method: The magnesium alloy of the present invention was made into microneedles, which were implanted into male rats by aseptic operation after disinfection, 6 in each group. After one month, a CT scan was performed to understand the metabolic status and differences of the microneedles in the rats. After 15 days and 1 month, X-ray films were taken to understand the general situation of the location and degradation. At 15 days and 1 month, the blood biochemical electrolyte changes of the rats were detected. And detect the degradation of the microneedle at different times to determine its degradation rate.
[0018] Experimental results: The blood supply of the microneedle implanted side in rats was strong. There was no significant difference in blood electrolyte detection among the groups. X-ray films in rats showed that the image of magnesium alloy was slightly blurred at 15 days, and the degree of X-ray light transmission was different. Histopathological sections of ...
Embodiment 2
[0020] Magnesium alloy microneedles were sterilized by fumigation, and implanted into white rabbits under strict aseptic operation. After the surgical wound was healed, the strain was adjusted to 0.5 McFarland units with PBS. Dilute the bacterial concentration to 1x106 / ml, inject 0.8ml of each bacterial strain onto the microneedles in the experimental rabbits, inject normal saline as a negative control, and take X-ray films of the experimental rabbits at 1 and 3 weeks after the injection of bacteria, and In the third week, the X-ray films in the experimental rabbits were taken, and local histopathological section examinations were performed to identify the bacterial types.
[0021] Experimental results: The smoothness of the magnesium alloy used at the beginning is the same as that of other alloy materials. It was found that there is no significant difference in the bacterial adhesion of P62A and 12228, and the bacterial count is in an order of magnitude. After changing the sur...
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