Degradable ultrafine needle piece

A needle-shaped and ultra-fine technology, which is applied in the direction of drug devices and other medical devices, can solve problems such as discount of cosmetic liquid penetration effect, dermatitis, infectious diseases, etc., and achieve good aging precipitation strengthening and solid solution strengthening effect. , The effect of improving electrode potential and low corrosion potential

Inactive Publication Date: 2015-12-09
陈彦彪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual use, because the microneedles are very dense, once the microneedles are broken during use, it will cause adverse reactions on the skin, such as dryness, redness, and even dermatitis. In severe cases, it will cause disfigurement or infection. In the production process, in order to ensure that it is not eas

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Method: The magnesium alloy of the present invention was made into microneedles, which were implanted into male rats by aseptic operation after disinfection, 6 in each group. After one month, a CT scan was performed to understand the metabolic status and differences of the microneedles in the rats. After 15 days and 1 month, X-ray films were taken to understand the general situation of the location and degradation. At 15 days and 1 month, the blood biochemical electrolyte changes of the rats were detected. And detect the degradation of the microneedle at different times to determine its degradation rate.

[0018] Experimental results: The blood supply of the microneedle implanted side in rats was strong. There was no significant difference in blood electrolyte detection among the groups. X-ray films in rats showed that the image of magnesium alloy was slightly blurred at 15 days, and the degree of X-ray light transmission was different. Histopathological sections of ...

Embodiment 2

[0020] Magnesium alloy microneedles were sterilized by fumigation, and implanted into white rabbits under strict aseptic operation. After the surgical wound was healed, the strain was adjusted to 0.5 McFarland units with PBS. Dilute the bacterial concentration to 1x106 / ml, inject 0.8ml of each bacterial strain onto the microneedles in the experimental rabbits, inject normal saline as a negative control, and take X-ray films of the experimental rabbits at 1 and 3 weeks after the injection of bacteria, and In the third week, the X-ray films in the experimental rabbits were taken, and local histopathological section examinations were performed to identify the bacterial types.

[0021] Experimental results: The smoothness of the magnesium alloy used at the beginning is the same as that of other alloy materials. It was found that there is no significant difference in the bacterial adhesion of P62A and 12228, and the bacterial count is in an order of magnitude. After changing the sur...

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PUM

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Abstract

The invention relates to the technical field of medical cosmetology instruments, in particular to a degradable ultrafine needle piece. The degradable ultrafine needle piece consists of degradable magnesium alloy. The magnesium alloy comprises the following chemical elements in parts by weight: 2-5 parts of neodymium, 0.1-0.5 part of zinc, 0.2-0.7 part of zirconium and the balanced magnesium metal. The magnesium alloy has lower corrosion potential, is easy to be corroded in the body of a person, and can be degraded completely and absorbed by the body of the person after being corroded slowly; magnesium is a necessary nutrient element of persons, and participates in energy metabolism of the body of the person; after the magnesium is absorbed by the body of the person, the circumstance that the content of serum magnesium is increased obviously is avoided; and the magnesium alloy has the neodymium which serves as a low alloying element, by the neodymium, the magnesium alloy has a good ageing precipitation strengthening and solution strengthening effect, electrode potential of an alloy matrix is improved, and homogeneous corrosion resistance of the magnesium alloy is improved. By the small amount of the zinc, the strength of the alloy and plastic working capability can be improved.

Description

technical field [0001] The invention relates to the technical field of medical cosmetic devices, in particular to a degradable ultramicro needle sheet. Background technique [0002] Micro-needle beauty technology uses micro-needles to pierce the stratum corneum of the skin to provide channels for the penetration of beauty products and promote the transdermal penetration of beauty products, thereby improving the beauty effect. In actual use, because the microneedles are very dense, once the microneedles are broken during use, it will cause adverse reactions on the skin, such as dryness, redness, and even dermatitis. In severe cases, it will cause disfigurement or infection. In the production process, in order to ensure that it is not easy to break, the selected length is shorter. Although this method can effectively avoid the occurrence of a large number of broken microneedles, the infiltration effect of the beauty liquid is also greatly reduced, and its maximum effect cannot...

Claims

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Application Information

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IPC IPC(8): A61M37/00C22C23/06
Inventor 陈彦彪
Owner 陈彦彪
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