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Extraction method of magnolia officinalis extract

An extraction method and extraction technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as complex process and low efficiency

Active Publication Date: 2015-12-09
海南恒光医药投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We have summarized and experimentally verified the current extraction and separation methods of magnolia bark. The common extraction and separation methods generally have the disadvantages of complex process and low efficiency.

Method used

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  • Extraction method of magnolia officinalis extract
  • Extraction method of magnolia officinalis extract
  • Extraction method of magnolia officinalis extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for extracting magnolia bark extract, said magnolia bark extract comprising magnolol and honokiol, prepared according to the following method:

[0033] a) 100 g of dry root powder of Magnolia officinalis that has been crushed to more than 20 meshes is extracted 4 times with 12 times, 10 times, 8 times and 6 times of 90% ethanol successively, and the extraction temperature is 75° C. to obtain an extract; The extract is filtered, and the filtrate is concentrated to dryness at a vacuum pressure of -0.08Mpa and a temperature of 50°C to obtain a concentrate;

[0034] b) Add 60 mL of ethyl acetate to the concentrate obtained in step a) to dissolve the concentrate, add 3 g of activated carbon to decolorize after dissolving, and concentrate to dryness at a vacuum pressure of -0.07Mpa and a temperature of 40°C to obtain crude Extract;

[0035] c) After dissolving the crude extract obtained in step b) with a mixed solvent of cyclohexane-ethyl acetate at a ratio of 5:1, ...

Embodiment 2

[0045] A method for extracting magnolia bark extract, said magnolia bark extract comprising magnolol and honokiol, prepared according to the following method:

[0046]a) 100 g of dry root powder of Magnolia officinalis that has been crushed to more than 20 meshes is extracted 4 times with 12 times, 10 times, 8 times and 6 times of 90% ethanol successively, and the extraction temperature is 80° C. to obtain an extract; The extract was filtered, and the filtrate was concentrated to dryness at a vacuum pressure of -0.086Mpa and a temperature of 55°C to obtain a concentrate;

[0047] b) Add 60 mL of ethyl acetate to the concentrate obtained in step a) to dissolve the concentrate, add 5 g of 200-mesh silica gel after dissolving to decolorize, and concentrate to dryness at a vacuum pressure of -0.07Mpa and a temperature of 45°C to obtain crude extract;

[0048] c) The crude extract obtained in step b) was dissolved in a mixed solvent of cyclohexane-ethyl acetate at a ratio of 5:1, ...

Embodiment 3

[0057] A method for extracting magnolia bark extract, said magnolia bark extract comprising magnolol and honokiol, prepared according to the following method:

[0058] a) 100 g of dry root powder of Magnolia officinalis that has been crushed to more than 20 meshes is extracted 4 times with 12 times, 10 times, 8 times and 6 times of 90% ethanol successively, and the extraction temperature is 85° C. to obtain an extract; The extract was filtered, and the filtrate was concentrated to dryness at a vacuum pressure of -0.09Mpa and a temperature of 60°C to obtain a concentrate;

[0059] b) Add 60 mL of ethyl acetate to the concentrate obtained in step a) to dissolve the concentrate, add 5 g of diatomaceous earth to decolorize after dissolving, and concentrate to dryness at a vacuum pressure of -0.08Mpa at a temperature of 50°C to obtain a crude extract ;

[0060] c) After dissolving the crude extract obtained in step b) with a mixed solvent of cyclohexane-ethyl acetate at a ratio of...

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Abstract

The present invention discloses an extraction method of a magnolia officinalis extract. The extraction method comprises: a) carrying out heating extraction on dried root powder with an alcohol solvent to obtain an extraction solution, filtering the extraction solution, and carrying out heating concentration under vacuum to achieve a dry state so as obtain a concentrate; b) collecting the concentrate, dissolving with an organic solvent, decolorizing, and carrying out heating concentration under vacuum to achieve a dry state so as obtain a crude extract; c) dissolving the crude extract with a mixed solvent, and obtaining a crude crystal at a temperature of 4-8 DEG C; d) dissolving the crude crystal with an alkaline solvent to form a solution for the column; e) loading the solution for the column into a polyamide chromatography column; f) respectively collecting the eluent, adjusting the pH value of the eluent with hydrochloric acid to achieve a neutral pH value, and respectively filtering to obtain a magnolol precipitate and a honokiol precipitate; and g) carrying out vacuum drying on the precipitates at a temperature of 50-60 DEG C to obtain the magnolol and the honokiol. According to the present invention, the process of the method is simple, the cost of the used chemical reagents is low, the purities of the extracted magnolol and the extracted honokiol are high, and the good economic benefits are provided.

Description

technical field [0001] The invention relates to the field of plant extracts, in particular to a method for extracting plant extracts. Background technique [0002] Magnolia officinalis Rehd.etWils is a deciduous tree of Magnoliaceae, an important traditional Chinese medicine in my country, and Magnolia officinalis Rehd. et Wils is listed as top grade in "Shen Nong's Materia Medica". Magnolia officinalis is used as medicine with dry bark, root bark, branch bark and flower bud. It has the effects of drying dampness and eliminating phlegm, lowering qi and eliminating fullness, and is used for dampness stagnation and injury, vomiting and diarrhea, food accumulation, stagnation of qi, abdominal distension and constipation, phlegm and water, dyspnea and cough. Magnolia officinalis is the main drug in traditional Chinese medicines and new medicines such as Kaixiong Shunqi Pills, Huoxiangzhengqi Pills, Muxiang Shunqi Pills, Biejiajian Capsules, Baoji Pills, and Xiangsha Yangwei Pil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/21C07C37/70
CPCC07C37/685C07C37/70C07C39/21
Inventor 蒲含林陈秀秀王亚峰朱义波
Owner 海南恒光医药投资有限公司
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