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A kind of antibacterial medical material and its preparation method and antibacterial medical device

A technology of polymer materials and antibacterial nanoparticles, applied in the field of medical devices, can solve the problems of limitation, unsatisfactory antibacterial effect, poor antibacterial durability of medical devices, etc., and achieve the effect of good antibacterial effect and good antibacterial durability.

Inactive Publication Date: 2018-02-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coating method is to coat the surface of the medical device with a layer of antibacterial agent. This method is simple to prepare, but is limited by the existing coating technology level, which makes the antibacterial durability of the obtained medical device poor.
The blending method is to prepare the corresponding medical device after the medical polymer material and the antibacterial agent are mixed through melting or solution. The antibacterial durability of the medical device made by the blending method is better than that of the coating method, but the medical device made by the blending method The surface antibacterial agent content is low, and the antibacterial effect is not ideal

Method used

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  • A kind of antibacterial medical material and its preparation method and antibacterial medical device

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preparation example Construction

[0041] The invention provides a kind of preparation method of antibacterial medical material, comprises the following steps:

[0042] Under ultrasonic conditions, the medical polymer material is impregnated in the antibacterial nano particle solution to obtain the antibacterial medical material.

[0043] In the preparation method provided by the invention, firstly, the medical polymer material is immersed in the antibacterial nano particle solution under ultrasonic conditions. Wherein, the medical polymer material is preferably one or more of fibers, resins and rubbers. The antibacterial nanoparticle solution is prepared by mixing the antibacterial nanoparticles and a solvent, and the antibacterial nanoparticles are preferably one of silver nanoparticles, zinc oxide nanoparticles, copper oxide nanoparticles, titanium dioxide nanoparticles and magnesium oxide nanoparticles. one or more species. The particle size of the antibacterial nanoparticles is preferably 50-200 nm, more...

Embodiment 1

[0066] (1) Soak medical gauze (Xianning Lifa Degreasing Gauze Products Factory) in 0.5wt% benzophenone ethanol solution, soak for 5 minutes, take it out, and air-dry naturally to obtain medical gauze coated with benzophenone. The medical gauze that the surface is coated with benzophenone is immersed in 8wt% polyethylene glycol acrylate (the number average molecular weight is 350) aqueous solution, under UV (365nm) photoinitiation, grafting reaction occurs on the surface of medical gauze, grafting 6min Finally, take it out, wash it with water, wash it with alcohol, and dry it successively to obtain a medical gauze modified by surface grafting.

[0067] (2) preparation of antibacterial silver nanoparticles (particle diameter is 80nm) ethanol solution, the concentration of antibacterial silver nanoparticles in the solution is 1mg / mL, the ultrasonic probe is placed in the antibacterial silver nanoparticles solution, ultrasonic (power is 288W) 1h in advance, The nanoparticles are d...

Embodiment 2

[0070] (1) Immerse the surgical gown (Shenzhen Duoai Textile Technology Co., Ltd.) in 0.5wt% benzophenone ethanol solution for 5 minutes, take it out, and dry it naturally to obtain a surgical gown coated with benzophenone. Immerse the surgical gown coated with benzophenone in a 6wt% hydroxyethyl acrylate aqueous solution, and under UV (365nm) photoinitiation, a grafting reaction occurs on the surface of the surgical gown. After 6 minutes of grafting, take it out, and then wash it with water and alcohol. After washing and drying, a surgical gown modified by surface grafting is obtained.

[0071] (2) preparation of antibacterial zinc oxide nanoparticles (particle diameter is 120nm) ethanol solution, the concentration of antibacterial zinc oxide nanoparticles in the solution is 1mg / mL, the ultrasonic probe is placed in the antibacterial zinc oxide nanoparticle solution, ultrasonic in advance (ultrasonic power is 300W) for 1h, so that the nanoparticles are dispersed in the soluti...

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Abstract

The invention belongs to the field of medical devices, and in particular relates to an antibacterial medical material, a preparation method thereof, and an antibacterial medical device. The material of the antibacterial medical device provided by the present invention includes medical polymer materials and antibacterial nanoparticles loaded on the medical polymer materials through ultrasonic impregnation. The material of the antibacterial medical device provided by the present invention is a novel antibacterial medical material, which includes a medical polymer material and antibacterial nanoparticles loaded on the medical polymer material by ultrasonic impregnation. Experimental results show that the antibacterial medical device provided by the present invention has better antibacterial effect and antibacterial persistence, and its antibacterial performance against E. , the antibacterial performance can still remain above 95%.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an antibacterial medical material, a preparation method thereof, and an antibacterial medical device. Background technique [0002] Disposable medical devices have become an indispensable tool in clinical medicine. When disposable medical devices come into contact with the human body, bacteria tend to adhere, proliferate and form biofilms on their surfaces. Due to the protective effect of the biofilm, the bacteria in the film will continue to multiply and release planktonic bacteria, causing repeated or worsening infections, and medical infection accidents are prone to occur; and disposable medical device infections are under strict clinical management and sterilization in hospitals. It cannot be avoided completely. Medical infection not only causes a high mortality rate, but also brings a heavy disease burden to patients, hospitals and society. Therefore, it is partic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/04A61L31/16
Inventor 石恒冲殷敬华栾世方刘海宇施德安尹立刚
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI