Titanium metal surface antibacterial treatment method
A treatment method, titanium metal technology, applied in the field of medical titanium metal surface treatment, can solve problems such as difficult to meet clinical requirements, functional disorders, antibiotic resistance, etc., to achieve excellent antibacterial and biocompatibility, and not easy to drug resistance , excellent antibacterial properties and biocompatibility effects
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Embodiment 1
[0034] The antibacterial treatment method of the titanium metal surface of the present embodiment, the steps are as follows:
[0035] (1) Treat the surface of medical titanium metal with 5% hydrofluoric acid for 3 minutes; (2) Dissolve the silane coupling agent with an alkynyl group in a mixed solution of water and ethanol, wherein the volume ratio of water and ethanol is 1 : 19, utilize acetic acid to adjust the pH of the solution to 3; (3) drip 10 microliters of the silane coupling agent solution in step (2) to the titanium metal surface, and carry out curing treatment, and the curing time is 4 hours; (4) configuration Click reaction solution, which consists of: 100 μM anhydrous copper sulfate, 2.5 mM sodium ascorbate, 100 μM antibacterial peptide KRWWKWWRR; (5) 1 mL of the above click reaction solution is added to the surface of titanium metal, and reacted in a nitrogen environment with an oxygen content lower than 1 ppm 3 hours; (6) Fully rinse the surface of the sample wi...
Embodiment 2
[0042] The antibacterial treatment method of the titanium metal surface of the present embodiment, the steps are as follows:
[0043] (1) Treat the surface of medical titanium metal with 10% hydrofluoric acid for 1 minute; (2) Use a mixed solution of water and ethanol as a solvent to dissolve the silane coupling agent with an alkynyl group, wherein the volume ratio of water and ethanol is 1 : 8, utilize acetic acid to adjust the pH of the solution to 5; (3) drip 100 microliters of the silane coupling agent solution in step (2) to the titanium metal surface, and carry out curing treatment, and the curing time is 1 hour; (4) configuration Click reaction solution, which consists of: 1000 μM anhydrous copper sulfate, 10 mM sodium ascorbate, 1000 μM antibacterial polypeptide KRWWKWWRRC; (5) 0.1 mL of the above click reaction solution is added to the surface of titanium metal, and reacted in a nitrogen environment with an oxygen content lower than 1 ppm 2 hours; (6) Fully rinse the ...
Embodiment 3
[0050] The antibacterial treatment method of the titanium metal surface of the present embodiment, the steps are as follows:
[0051] (1) Treat the surface of medical titanium metal with 8% hydrofluoric acid for 3 minutes; (2) Dissolve the silane coupling agent with an alkynyl group in a mixed solution of water and ethanol, wherein the volume ratio of water and ethanol is 1 : 15, utilize acetic acid to adjust the pH of the solution to 4.5; (3) 80 microliters of the silane coupling agent solution in the step (2) are added dropwise to the surface of the titanium metal for curing, and the curing time is 2 hours; (4) configuration Click reaction solution, which consists of: 1000 μM anhydrous copper sulfate, 8 mM sodium ascorbate, 800 μM antibacterial polypeptide KRWWKWWRR; (5) 3 mL of the above click reaction solution is added to the surface of titanium metal, and reacted in a nitrogen environment with an oxygen content lower than 1 ppm for 3 (6) Fully rinse the surface of the sam...
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