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Traditional Chinese medicine preparation for treating acute episode stage of wind-damp-heat type gout

A traditional Chinese medicine preparation and a gout attack technology are applied in the field of medicines for treating acute and chronic gout, can solve problems such as the limitation of subjects, and achieve the effects of reducing toxic side effects, good treatment of gout, and good therapeutic effects

Inactive Publication Date: 2015-12-30
刘凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of manpower, material resources and practice, there are still few multi-center clinical trials with large samples, and the subjects are often limited to certain characteristic populations or certain specific regions.

Method used

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  • Traditional Chinese medicine preparation for treating acute episode stage of wind-damp-heat type gout
  • Traditional Chinese medicine preparation for treating acute episode stage of wind-damp-heat type gout
  • Traditional Chinese medicine preparation for treating acute episode stage of wind-damp-heat type gout

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preparation example Construction

[0058] The present invention also provides a preparation method for preparing the above-mentioned traditional Chinese medicine preparation into granules, which includes:

[0059] In the first step, the components in the raw material components are mixed in proportion, crushed, soaked in water for 12-24 hours in an amount 4-8 times the mass of the mixture, and the volatile oil is extracted by steam distillation, and the distilled medicinal residues are Save it with the liquid medicine;

[0060]In the second step, the volatile oil in the first step is dissolved in ethanol with an alcohol concentration of 65% in a mass ratio of 1:1, and the colloidal milling method is adopted, and the mass ratio of the volatile oil to β-cyclodextrin is 1:5-8 , the mass ratio of β-cyclodextrin to water is 1:2-4, grinding for 15-30 minutes for clathrate to obtain a paste, drying at 50-60°C, and pulverizing to obtain clathrate;

[0061] In the third step, the medicinal solution obtained in the firs...

Embodiment 1

[0065] Embodiment 1 Granule 1

[0066] Phellodendron 2000g, Fangji 1000g, Coix seed 3000g, Anemarrhena 2000g, Atractylodes 1500g, Smilax tuckahoe 3000g, Plantago 1500g, talc 1500g, Salt Alisma 1500g, Clematis 1000g, Gentiana 2000g, Fenxenia 1000g, Sichuan achyranthes Mix 2000g, 1500g Polygonum cuspidatum, 1500g dried tangerine peel, 1500g light bamboo leaves, 2000g Shichangpu, 2000g Spathiphyllum vine, 2000g Caulis Spatholobus, 1500g mulberry branch, 1500g red peony root, 1000g raw licorice, mix them, crush them, and use 6 times the amount of water relative to the mass of the mixture Soak for 24 hours, extract the volatile oil by steam distillation, save the distilled medicinal residues and medicinal liquid separately, add the volatile oil to 65% ethanol in a ratio of 1:1 by mass to dissolve, and use colloid milling method to mix the volatile oil with β -The mass ratio of cyclodextrin is 1:6, the mass ratio of β-cyclodextrin and water is 1:3, grind for 30 minutes for clathrate...

Embodiment 2

[0068] Cortex Phellodendron 2500g, Fangji 1500g, Coix Seed 2500g, Anemarrhena 2500g, Atractylodes 1500g, Smilax tuckahoe 2500g, Plantago 1000g, Talc 1500g, Salt Alisma 1500g, Clematis 1500g, Gentiana 1500g, Fenxenia 1500g, Sichuan Achyranthes bidentata 1500g , 1500g of Polygonum cuspidatum, 1500g of tangerine peel, 1500g of light bamboo leaves, 1500g of Shichangpu, 1500g of Spathiphyllum vine, 1500g of Caulis Spatholobus, 1500g of mulberry branch, 1000g of red peony root, 500g of raw licorice, mixed, crushed, and soaked in water 6 times the mass of the mixture For 24 hours, the volatile oil was extracted by steam distillation, and the distilled medicinal residues and medicinal liquid were stored separately. The volatile oil was dissolved in ethanol with an alcohol concentration of 65% in a mass ratio of 1:1, and the colloidal milling method was used to mix the volatile oil with β- The mass ratio of cyclodextrin is 1:6, the mass ratio of β-cyclodextrin and water is 1:3, grind fo...

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Abstract

The invention provides a traditional Chinese medicine preparation for treating an acute episode stage of wind-damp-heat type gout. The traditional Chinese medicine preparation comprises the following raw medicinal materials, namely golden cypress, stephania terandra, coix seeds, rhizoma anemarrhenae, rhizoma atractylodis, rhizoma smilacis glabrae, semen plantaginis, talc, salted rhizoma alismatis, radix clematidis, large-leaved gentian, rhizoma dioscoreae hypoglaucae, medicinal cyathula root, ploygonum cuspidatum, pericarpium citri reticulatae, lophatherum gracile, rhizoma acori graminei, Chinese starjasmine stem, caulis spatholobi, ramulus mori, radix paeoniae rubra and raw glycyrrhiza uralensis. The traditional Chinese medicine preparation provided by the invention takes the effects of clearing away heat and drying dampness, removing damp and turbid, and activating meridians to stop pain in allusion to the treatment to the acute episode stage of wind-damp-heat type gout, in combination with the knowledge to theory of traditional Chinese medicine of the wind-damp-heat type gout and clinical manifestations of patients and by means of syndrome differentiation and treatment and formula compatibility, has a favorable treatment effect, has the capability of remarkably reducing the toxic and side effects of western medicines and is safe and effective when being taken under a conventional dosage. According to comprehensive assessments, the traditional Chinese medicine preparation provided by the invention has a favorable effect of treating the gout and should be clinically generalized under the support of experimental evidences.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating acute and chronic gout. Background technique [0002] Gout is a group of diseases caused by disturbance of purine metabolism, excessive production or decreased excretion of uric acid. When the blood uric acid concentration is too high, it is easy to form uric acid crystals and deposit in joints, kidneys, etc., destroy the organelles of phagocytes, erode tissues, stimulate immune responses, cause and accelerate the development of inflammatory reactions of foreign bodies in tissues, and the most common is deposition Gouty arthritis is caused in joints and cartilage, and it is manifested as severe pain, redness and swelling of joints during acute attack, which has become the primary reason for many patients to seek medical treatment. The disease has a relatively high incidence in western countries. In recent years, with the continuous im...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/8994A61P19/06
Inventor 不公告发明人
Owner 刘凯
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