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A kind of fluorescent mesoporous silica composite nanoparticle and preparation method thereof

A technology of mesoporous silica and composite nanoparticles, which is applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of easy clogging of loaded fluorescent dyes, complicated preparation process, large solvent consumption, etc., and achieves low cost, low preparation Simple method and less environmental pollution

Inactive Publication Date: 2017-07-11
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the traditional method is the post-loading method, which is to prepare mesoporous silica first, and then load the fluorescent dye on it. Therefore, the preparation process of this method is complicated, and the small pore size is easy to block, so that the loading of the fluorescent dye is limited. At the same time, when the dye is loaded Both need to consume a lot of solvents and pollute the environment

Method used

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  • A kind of fluorescent mesoporous silica composite nanoparticle and preparation method thereof
  • A kind of fluorescent mesoporous silica composite nanoparticle and preparation method thereof
  • A kind of fluorescent mesoporous silica composite nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Ultrasonic dispersion of 0.005 g of the fluorescent dye rhodamine B in 1 mL of chloroform was performed to obtain a chloroform solution of the fluorescent dye. Take by weighing 0.1g cationic surfactant cetyltrimethylammonium bromide, dissolve it in 10mL deionized water, obtain a concentration of surfactant solution that is 0.01g / mL, add the fluorescent dye prepared above Chloroform solution, after stirring and dispersing evenly, the obtained milk tea-like emulsion. Then the emulsion is heated to 65°C, and the organic solvent is completely volatilized by rapid mechanical stirring (it takes about 30 minutes), and a fluorescent dye solution dispersed in the water phase is obtained.

[0022] Add 110mL of deionized water and 2mL of ammonia solution (concentration: 25wt%) to the fluorescent dye dispersion solution obtained above, heat to 30°C, control the stirring speed at 300rp / min, stir mechanically for 2 hours, and then add 1g of raw orthosilicon dropwise Acetate ethyl es...

Embodiment 2

[0025] The fluorescent mesoporous silica composite nanoparticles containing the cationic surfactant cetyltrimethylammonium bromide template were prepared by a method similar to that of Example 1, the difference being the quality of the raw material tetraethyl orthosilicate It is 2.5g.

[0026] The same method as in Example 1 was used to test the particle size of the fluorescent mesoporous silica composite nanoparticles prepared in this example. Tested by a particle size analyzer, the obtained composite nanoparticles have an average particle size of 281nm, a pore size of 2.3nm, a normal distribution of particle size, and a particle size polydispersity index of 0.2.

Embodiment 3

[0028] Fluorescent mesoporous silica composite nanoparticles containing the cationic surfactant cetyltrimethylammonium bromide template were prepared by a method similar to that of Example 1, except that the amount of ammonia water added was 5 mL.

[0029] The same method as in Example 1 was used to test the particle size of the fluorescent mesoporous silica composite nanoparticles prepared in this example. As tested by a particle size analyzer, the obtained composite nanoparticles have an average particle size of 339nm, a pore size of 3.2nm, a normal distribution of particle size, and a particle size polydispersity index of 0.03.

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Abstract

The invention relates to fluorescent mesoporous silica composite nanoparticles and a preparing method thereof. The composite nanoparticles are obtained by dispersing fluorescent dye molecules into pores of mesoporous silica matrixes, wherein the particle size of the mesoporous silica matrixes ranges from 100 nm to 135 nm, the particle size polydispersity index ranges from 0.03 to 0.2, and the pore diameter ranges from 2 nm to 3.2 nm. The preparing method of the fluorescent mesoporous silica composite nanoparticles includes the steps that the fluorescent dye is firstly dissolved into an organic solvent, then subjected to phase transfer into water through the surfactant hexadecyl trimethyl ammonium bromide, and then forms a shell layer of the mesoporous silica through a solvent and gel reaction, and the fluorescent mesoporous silica composite nanoparticles are obtained after centrifugal washing drying is conduced. The preparing method is simple, the load amount of the fluorescent dye can be increased, and the obtained fluorescent mesoporous silica composite nanoparticles are high in fluorescence intensity and good in anti-aging performance.

Description

technical field [0001] The invention relates to the technical field of fluorescent nanomaterials, and specifically relates to a fluorescent mesoporous silica composite nanoparticle and a preparation method thereof. Background technique [0002] Mesoporous silica nanoparticles (MSNs) have gradually become carriers for biomedical imaging, drug delivery, and catalysts due to their uniform and tunable pore size, large specific surface area, good surface properties, and biocompatibility. Fluorescent materials have excellent properties of absorbing ultraviolet rays and emitting visible light, and have broad application prospects in the fields of optics, sensing, decoration, anti-counterfeiting, and biomarkers. Among them, fluorescent dyes have been commercialized in large quantities due to their high luminous purity, absorption and emission wavelength ranges covering the entire visible region, but fluorescent dyes are also susceptible to solvent molecules, and when the concentrati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/06
Inventor 王勇杨大林
Owner WUHAN UNIV OF TECH