Method for correcting human genome damage through micro nutrient substances according to genetic background

A genome damage and nutrient technology, applied in the fields of nutritional genomics and medical genetics, can solve the problems that have not been seen before, and achieve the effect of maintaining stability and preventing cardiovascular diseases.

Inactive Publication Date: 2015-12-30
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the application of folic acid and VB12 is mostly focused on the treatment of anemia and the prevention of birth defects. According to the genetic background and nutritional status, the rational int

Method used

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  • Method for correcting human genome damage through micro nutrient substances according to genetic background
  • Method for correcting human genome damage through micro nutrient substances according to genetic background

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] A method for correcting human genome damage with micronutrients based on genetic background, comprising the steps of:

[0063] (1) Detection of blood folic acid level:

[0064] S1. Acquisition of serum: collect individual peripheral blood with a coagulation-promoting tube, then put it at 4°C for coagulation for 1 hour, centrifuge at 2500 rpm for 15 minutes, and the yellow supernatant is serum, which is divided into 300 μl each, and stored at -20°C in the dark;

[0065] S2. Detection of serum folic acid level: After the serum sample was thawed at room temperature for half an hour, the sample was added to the BECKMANAccess2 automatic immune analyzer for detection, and the serum folic acid value of the tested sample was obtained;

[0066] S3. Red blood cell acquisition: collect individual peripheral blood with EDTA-anticoagulant tube, centrifuge at 1000rpm for 5min to separate red blood cells, wash red blood cells three times with normal saline, centrifuge at 1000rpm for 5...

Embodiment 2

[0113]A method for correcting human genome damage with micronutrients based on genetic background, comprising the steps of:

[0114] (1) Detection of blood folic acid level:

[0115] S1. Acquisition of serum: Collect individual peripheral blood with a coagulation-promoting tube, then place it at 4°C for coagulation for 1 hour, centrifuge at 2500 rpm for 20 minutes, and the yellow supernatant is serum, which is divided into 300 μl each, and stored at -20°C in the dark;

[0116] S2. Detection of serum folic acid level: After the serum sample was thawed at room temperature for half an hour, the sample was added to the BECKMANAccess2 automatic immune analyzer for detection, and the serum folic acid value of the tested sample was obtained;

[0117] S3. Red blood cell acquisition: collect individual peripheral blood with EDTA-anticoagulant tube, centrifuge at 1000rpm for 10min to separate red blood cells, wash red blood cells three times with normal saline, centrifuge at 1000rpm for...

Embodiment 3

[0164] A method for correcting human genome damage with micronutrients based on genetic background, comprising the steps of:

[0165] (1) Detection of blood folic acid level:

[0166] S1. Serum acquisition: collect individual peripheral blood with a coagulation-promoting tube, then put it at 4°C for coagulation for 1 hour, centrifuge at 2500rpm for 18 minutes, and the yellow supernatant is serum, which is divided into 300 μl each, and stored at -20°C in the dark;

[0167] S2. Detection of serum folic acid level: After the serum sample was thawed at room temperature for half an hour, the sample was added to the BECKMANAccess2 automatic immune analyzer for detection, and the serum folic acid value of the tested sample was obtained;

[0168] S3. Red blood cell acquisition: collect individual peripheral blood with EDTA-anticoagulant tube, centrifuge at 1000rpm for 7min to separate red blood cells, wash the red blood cells three times with normal saline, centrifuge at 1000rpm for 5...

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Abstract

The invention relates to a method for correcting human genome damage through micro nutrient substances according to the genetic background and belongs to the technical field of nutrition genomics and medical genetics application. The method comprises the steps that peripheral blood of an individual is sampled, the levels of folate of the blood, serum VB12 and serum Hcy are detected, nuclear DNA is extracted, the MTHFR C677T and A1298C genetypes and the genome damage condition of the individual are combined, and micro nutrient substance intervention suggestions are given to the individual with the high genome damage according to reference values (the folate of erythrocyte is higher than 700 nM, the serum folate is higher than 34 nM, the serum VB12 is higher than 300 pM, and the serum Hcy is lower than 8 micrometers) at which various blood micro nutrient substances maintain the stability of genomes, so that the heredity damage of the individual is corrected, and the stability of the genomes is maintained. The strategy is beneficial to preventing cardiovascular diseases and reducing the risk factor of genome damage related diseases.

Description

technical field [0001] The invention is a method for correcting human genome damage with micronutrients based on genetic background, which belongs to the technical field of nutritional genomics and medical genetics, and aims to correct genome damage through micronutrients and reduce environmental-genetic related diseases in some individuals , degenerative disease risk targets. Background technique [0002] Micronutrients are mainly minerals and vitamins, which are indispensable but less required by the human body. Some micronutrients serve as substrates or cofactors for important reactions such as genetic material metabolism, damage repair, and epigenetic modification. important role in injury. [0003] Folate, as an important class of micronutrients, participates in the metabolism of one-carbon units in organisms. The human body cannot synthesize folic acid and must be ingested from the outside world. Since folic acid is involved in two important biochemical processes of...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/82
CPCC12Q1/6883C12Q1/6858C12Q2600/156G01N33/82C12Q2531/113C12Q2521/301C12Q2565/125
Inventor 汪旭倪娟梁子卿薛京伦
Owner YUNNAN NORMAL UNIV
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