Micro-fluidic chip system for improving radiation flux of single ion beam

A microfluidic chip, single ion beam technology, applied in color/spectral property measurement, fluorescence/phosphorescence, material excitation analysis, etc., can solve problems such as inability to online in-situ detection, low radiation flux, etc., and achieve stable experimental data Reliable, elimination of toxic effects, consistent effect of irradiation parameters

Active Publication Date: 2015-12-30
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a microfluidic chip system for increasing the irradiation flux of a single ion bea

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  • Micro-fluidic chip system for improving radiation flux of single ion beam

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[0016] The technical solutions of the present invention will be further specifically described below in conjunction with specific embodiments.

[0017] Such as figure 1 As shown, the microfluidic chip system used to increase the irradiation flux of a single ion beam is placed above the beam irradiation outlet, and glass is used as the substrate material of the microfluidic chip. The microfluidic chip has a culture medium reservoir , microchannels, real-time detection of cell electrodes, irradiation points, filters, cell pools and other functional structures. The front end of the medium storage tank is connected with a multi-channel drive pump, which is used to drive the medium suspension forward and inject CO into the medium. 2 and O 2 , to regulate the acid-base balance and oxygen content of the medium to meet the conditions for cell survival. The drive system can quickly drive the microfluidics to make steady motion or stand still. The microchannel and the reservoir are ...

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Abstract

The invention discloses a micro-fluidic chip system for improving a radiation flux of a single ion beam. The micro-fluidic chip system comprises a culture medium storage tank and a micro channel, wherein the micro channel only allows a single cell to pass through in a queue manner, a real-time detection cell electrode is respectively installed at two sides of the micro channel, a radiation point is arranged in front of the real-time detection cell electrodes, and the thickness of the radiation point is less than or equal to 5 micrometers; the real-time detection cell electrode pair generate a differential signal, the micro-fluidic impedance variation in the channel is detected by virtue of the signal processing technology so as to rapidly identify whether the cell passes through or not, a cell identification signal accesses a beam control system of a single ion beam device, so that when the cell passes through the radiation point, the beam control system can control ions to accurately and timely radiate the cell. The micro-fluidics are used for the single ion beam radiation device for the first time, the radiation flux is improved by several tens of times, the requirement on the large dosage of cells for the biology experiment can be met, a novel high-flux technical platform is provided for the radiation biology, and the commercial application prospect is vast.

Description

technical field [0001] The invention belongs to the field of microfluidic chip systems, and in particular relates to a microfluidic chip system for improving the irradiation flux of a single ion beam and an application method thereof. Background technique [0002] Cell biology experiments (such as genetic mutation research) require tens of thousands of cell samples. On the one hand, the experimental data is required to be statistically significant, and unstable and accidental factors are excluded; on the other hand, in each cell experiment, a large number of cells need to be tested in many ways. In addition, the cells have apoptosis failure, so a large number of cells to complete the experiment. High-throughput detection technology can make the experimental conditions of each cell sample more consistent, make the experimental data more authentic and reliable, and significantly improve the experimental efficiency. [0003] However, due to technical limitations, the irradiat...

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Application Information

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IPC IPC(8): G01N21/25G01N21/64
Inventor 詹福如吴李君陈连运卞坡黄青袁航
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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