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A kind of anti-myocardial hypertrophy pharmaceutical composition and preparation method thereof

A technique for myocardial hypertrophy and composition, applied in the field of anti-myocardial hypertrophy pharmaceutical composition and its preparation, capable of solving problems such as myocardial hypertrophy

Active Publication Date: 2019-04-05
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no natural medicinal composition to address cardiac hypertrophy

Method used

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  • A kind of anti-myocardial hypertrophy pharmaceutical composition and preparation method thereof
  • A kind of anti-myocardial hypertrophy pharmaceutical composition and preparation method thereof
  • A kind of anti-myocardial hypertrophy pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] 1.3.1 Preparation of rat left ventricular hypertrophy model

[0061] Rats were reared in separate cages, and after one week of adaptation to the environment, the blood pressure of the rats was measured three times with the BESN-II four-channel animal non-invasive manometry system. The rats whose blood pressure met the standard were randomly divided into ten rats in each group, and marked with picric acid solution. After anesthetized by intraperitoneal injection of 4% pentobarbital sodium at 40 mg / kg, the rat was fixed on a small wooden board in the supine position, the abdominal mouse hair was cut off, disinfected with iodophor, and a long 2 A longitudinal incision of ~3 cm was made. After entering the abdominal cavity, the abdominal organs were retracted to expose the surgical field. The abdominal aorta was explored about 3 mm above the branch point of the right renal artery from the abdominal aorta, and a small section of the abdominal aorta was separated, and then us...

Embodiment 1

[0254] Embodiment 1 A kind of capsule preparation method of anti-cardiac hypertrophy

[0255] (1) Extract total saponins from ginseng stems and leaves: take ginseng stems and leaves coarse powder, add 70% ethanol and heat reflux to extract twice at 76° C. The ratio of ethanol is added, each time for 4 hours, coarse filtration, the obtained extracts are combined and concentrated, the ethanol is recovered, and the extract is obtained, and then the concentrated extract is dissolved in 6 times of water, centrifuged, and the clear liquid is adjusted. The density is 1.08 at 25°C, and after being adsorbed by D101 macroporous resin, it passes through 9 times column volume of water, 9 times column volume of 30% ethanol, 10 times column volume of 70% ethanol and 5 times column volume of 95 Gradient elution with % ethanol in sequence, finally collect the 70% ethanol eluate, concentrate in a rotary evaporator to a thick paste, recover ethanol, dry at 70-80°C, and obtain the ginseng stem a...

Embodiment 2

[0267] Embodiment 2 A kind of preparation method of anti-myocardial hypertrophy granule

[0268] (1) Extract total saponins from ginseng stems and leaves: take ginseng stems and leaves coarse powder, add 70% ethanol and heat reflux to extract twice at 76° C. The ratio of ethanol is added, each time for 4 hours, coarse filtration, the obtained extracts are combined and concentrated, the ethanol is recovered, and the extract is obtained, and then the concentrated extract is dissolved in 7 times of water, centrifuged, and the clear liquid is adjusted. The density is 1.09 at 25°C, and after being adsorbed by D101 macroporous resin, it passes through 9 times column volume of water, 9 times column volume of 30% ethanol, 10 times column volume of 70% ethanol and 5 times column volume of 95 Gradient elution with % ethanol in sequence, and finally collect the 70% ethanol eluate, concentrate in a rotary evaporator to a thick paste, recover ethanol, dry at 75°C, and obtain the ginseng st...

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Abstract

The invention discloses medicine composition resistant to myocardial hypertrophy. The medicine composition comprises components in parts by weight as follows: 78-98 parts of ginseng stem and leaf extract, 64-84 parts of szechuan lovage rhizome extract and 78-98 parts of medcinal evodia fruit extract and preferably comprises 88 parts of ginseng stem and leaf extract, 74 parts of szechuan lovage rhizome extract and 88 parts of medcinal evodia fruit extract, wherein the ginseng stem and leaf extract contains 38%-50% of total saponins, the szechuan lovage rhizome extract contains 30.0%-38% of total phenolic acid, and the medcinal evodia fruit extract contains 8.0%-12.0% of total alkaloid; the ginseng stem and leaf extract, the szechuan lovage rhizome extract and the medcinal evodia fruit extract are all extracted with an alcohol extraction method. The dosage of the medicine composition for rats comprises 78-98 mg / kg / d of the ginseng stem and leaf extract, 64-84 mg / kg / d of the szechuan lovage rhizome extract and 78-98 mg / kg / d of the medcinal evodia fruit extract and preferably comprises 88 mg / kg / d of the ginseng stem and leaf extract, 74 mg / kg / d of the szechuan lovage rhizome extract and 88 mg / kg / d of the medcinal evodia fruit extract. The formula of the medicine composition is reasonable, and the medicine composition does not have remarkable acute toxin and can effectively resist to myocardial hypertrophy.

Description

technical field [0001] The invention relates to a pharmaceutical composition for resisting cardiac hypertrophy and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Myocardial hypertrophy is a slow but effective compensatory function, which mainly occurs in the case of long-term pressure overload. There are considerable reserves. But this compensatory function also has its disadvantages, mainly because the hypertrophy of the myocardium requires increased oxygen, and the blood supply of the coronary arteries is often not satisfied, resulting in myocardial ischemia, which will eventually lead to a decrease in myocardial contractility. Myocardial hypertrophy is an independent risk factor for cardiovascular accidents, which is more harmful than smoking and hypercholesterolemia. Studies have found that with the occurrence and development of left ventricular hypertrophy, the incidence of cardiovascular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/754A61P9/00A61P9/04
Inventor 黄燮南邓江周旭美
Owner ZUNYI MEDICAL UNIVERSITY
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