Preparation method of decoquinate

A technology of decoquinate and sodium hydroxide, which is applied in the field of poultry medicine preparation technology, can solve the problems of high reaction temperature, high equipment requirements, and easy spraying of materials, and achieve high selectivity, short process route, and no corrosion The effect of the device

Inactive Publication Date: 2016-01-20
ZHOUKOU NORMAL UNIV
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  • Abstract
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Problems solved by technology

CN102816117 and CN102766094 both use high temperature (above 250°C) cyclization to obtain the target product, but due to the high reaction temperature, high equipment requirements, and carbonization of some products, it is difficult to purify, and the yield is low
However, when phosphorus oxychloride is used for cyclization, the target product cannot be synthesized in one step, a...

Method used

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  • Preparation method of decoquinate

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Embodiment Construction

[0019] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0020] Such as figure 1 As shown, the embodiment of the present invention provides a preparation method of decoquinate, comprising the following steps:

[0021] S1, diazotization

[0022] Put 7.5 parts of aniline and 22 parts of water into the reaction kettle, cool down to 0°C, stir slowly, add 21 parts of 30-32% concentrated hydrochloric acid, after the addition is completed, the temperature drops to 0°C, and then add sodium nitrite solution (5.9 part, 22 parts of water), after the flow addition is completed, continue to react at this temperature for 1h to obtain the diazonium salt solution of aniline, which is kept at low temperature for sub...

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Abstract

The invention discloses a preparation method of decoquinate. Industrialized 2-hydroxyphenylacetic acid phenetole serves as starting materials, and a product with better quality is obtained through diazo coupling, sodium dithionite reduction, condensation, etherificationa and superstrong solid acid SO4<2->/Fe2O3 and sodium bisulfate cyclization. Part intermediate of a synthetic route of the decoquinate does not need to be purified, used solvent is single, aftertreatment of the intermediate and use of organic solvent are reduced, the cost is reduced, the whole process route is short, extremely high temperature or highly corrosive liquid acid is not needed, requirement to equipment is low, operation is easy and convenient, the production cycle is short, produced three wastes are fewer, the production yield is high, the quality is good, and the preparation method of the decoquinate is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation process of poultry medicine, in particular to a preparation method of decoquinate. Background technique [0002] Decoxyquinate was developed by the May-Baker Company in the United Kingdom in the 1960s. It has broad-spectrum anticoccidial activity and can be used for chickens caused by poisonous, tender, giant, heap-type and Eimeria brucei. Coccidiosis has a broad market prospect. Decoxyquinate plays an important role in the DNA synthesis process of coccidia, mainly preventing its reproduction by interfering with DNA synthesis. Decoxyquinate has low toxicity, good tolerance, fast absorption, and can reach an effective concentration in a short time. Moreover, it metabolizes quickly in animals and has low residues, and has been widely used in Europe, America and other countries. [0003] The cyclization reaction in the decoquinate synthesis process can be carried out under the action of a high boiling point solvent...

Claims

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Application Information

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IPC IPC(8): C07D215/56
CPCC07B2200/13C07D215/56
Inventor 杨志广王全忠石晓明彭鹏李可
Owner ZHOUKOU NORMAL UNIV
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