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Micro-powder capsule for treating peptic ulcer

A technology of capsules and micropowders, applied in the field of micropowder capsules, which can solve the problems of high cost, many medicinal flavors, and large dosage of medicinal materials, and achieve good pain relief effects, effective treatment of gastric ulcers, and good gastric mucosal repair effects

Inactive Publication Date: 2016-01-27
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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  • Micro-powder capsule for treating peptic ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0026] Zushima 30g, Anisopolamine 5g, Dried Ginger 90g, Seabuckthorn 100g; after drying, crush to 200 mesh, mix evenly to get raw material medicine powder.

[0027] According to raw material drug powder: dextrin = 100: 20g / g, the raw material drug powder and dextrin are mixed evenly, sprayed with 10% w / v starch slurry as a binder, wet granulated, and dried to obtain drug granules.

[0028] According to drug granules: magnesium stearate=100:3g / g, the drug granules and lubricant are mixed, and packed into capsules to obtain the capsules of the present invention.

Embodiment 2

[0029] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0030] Zushima 100g, Anisopolamine 60g, Dried Ginger 600g, Seabuckthorn 1000g; after drying, crush to 300 mesh, mix evenly to get raw material medicine powder.

[0031] According to raw material drug powder: dextrin = 100: 50g / g, the raw material drug powder and dextrin are mixed evenly, 70% ethanol is used as a binder, wet granulation, and drying to obtain drug granules.

[0032] According to medicine granule: magnesium stearate=100:4g / g, medicine granule and lubricant are mixed, pack into capsule, promptly obtain the capsule of the present invention.

Embodiment 3

[0033] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0034] Zushima 10g, Anisopolamine 3g, Dried Ginger 100g, Seabuckthorn 60g; after drying, crush to 400 mesh, and mix well to get raw material medicine powder.

[0035] According to raw material drug powder: dextrin = 100: 30g / g, the raw material drug powder and dextrin are mixed uniformly, water is used as a binder, wet granulation is carried out, and drying is performed to obtain drug granules.

[0036] According to medicine granule: magnesium stearate=100:2g / g, medicine granule and lubricant are mixed, pack into capsule, promptly obtain the capsule of the present invention.

[0037] The beneficial effects of the present invention are further demonstrated through specific test examples below.

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Abstract

The invention discloses a micro-powder capsule for treating peptic ulcer. The micro-powder capsule comprises, by weight, 100 parts of medicine particles and 1-5 parts of lubricants. A capsule is filled with the medicine particles and the lubricants to obtain the micro-powder capsule after the medicine particles and the lubricants are uniformly mixed with one another. A method for preparing the medicine particles includes (1), weighing, by weight, 1-3 parts of daphne giraldii nitsche, 0.3-0.6 part of anisodus tanguticus, 6-10 parts of dried ginger and 6-10 parts of sea buckthorn; (2), grinding raw materials until the particle sizes of the raw materials are 200-500 meshes, and uniformly mixing the raw materials with one another to obtain raw material powder; (3), uniformly mixing dextrin and the raw material powder with each other according to a ratio of the raw material powder to the dextrin of 100:20-50 w / w, and preparing the medicine particles by the aid of a wet process. The micro-powder capsule has the advantages that synergistic effects can be realized by medicine compositions after the medicine compositions are reasonably compatible with one another, accordingly, the peptic ulcer can be effectively treated, and a novel medication option can be provided for clinically treating the peptic ulcer.

Description

technical field [0001] The invention relates to a micropowder capsule for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness after meals, pantothenic acid, belching, and irregular abdominal pain. Multiple verrucous, ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/48A61P1/04
Inventor 卞海军徐继锋许婧
Owner 门源县雪草木生物药业有限公司
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