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A kind of artificial blood vessel and its preparation method and acupuncture mold

An artificial blood vessel and acupuncture technology, applied to blood vessels, devices with human tubular structures, non-woven fabrics, etc., can solve problems such as complex processes, easily damaged blood vessels, poor penetration resistance of fabrics, etc., to achieve firm bonding and improve mechanical strength , Improve the effect of anti-penetration ability

Active Publication Date: 2018-01-19
ACCUPATH MEDICAL JIAXING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires repeated electrospinning, and the process is complicated; the prior art also discloses a double-layer artificial blood vessel with an outer layer composed of a woven, knitted or braided structure and an inner layer composed of nanofibers
The nanofiber layer is prepared by electrospinning. After the spinning is completed, the surface where the nanofibers are collected is turned over to the inner layer to form the inner surface of the artificial blood vessel, but turning over is easy to damage the blood vessel.
[0005] The important problem existing in the existing artificial blood vessels is that the anti-permeability of the fabric is still relatively poor, and the mechanical strength is not enough

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • A kind of artificial blood vessel and its preparation method and acupuncture mold
  • A kind of artificial blood vessel and its preparation method and acupuncture mold
  • A kind of artificial blood vessel and its preparation method and acupuncture mold

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preparation example Construction

[0027] figure 1 For the schematic flow chart of the preparation of the artificial blood vessel in the preferred embodiment of the present invention, please refer to figure 1 , the preparation method of the artificial blood vessel comprises the following steps:

[0028] Step S1: Cut the fabric and sew the fabric into a cylindrical shape with surgical sutures to form the inner wall of the blood vessel; the fabric can be polyester, spandex, silk, polytetrafluoroethylene or their blended materials; the cylindrical shape The diameter of the fabric is consistent with the required diameter of human blood vessels, and the preferred diameter range is 6mm-38mm.

[0029] Step S2: Set the stitched cylindrical fabric on a metal rod matching its diameter, and directly use the metal rod covered with the cylindrical fabric as the receiving end to perform electrospinning; make the nanofibers along the cylindrical shape The outer surface of the fabric grows in the circumferential direction an...

Embodiment 1

[0035] Cut the polyester woven fabric into a size of 100*30mm, sew it into a tube with a length of 100mm with surgical sutures, and wrap it on a metal rod of an appropriate size. The metal rod was used as the receiving end of the electrospinning equipment and rotated evenly at a speed of 50 r / min. The prepared 10% polylactic acid solution was electrospun. The spinning voltage is 15kV; the receiving distance is 15cm. After spinning is complete, the artificial vascular product is removed from the metal rod. Put the spun artificial blood vessel on a rubber rod of corresponding diameter, use a special acupuncture mold to acupuncture the artificial blood vessel, and rotate the artificial blood vessel to ensure uniform puncture.

Embodiment 2

[0037] Cut the silk woven fabric into a size of 100*20mm, sew it into a tube with a length of 100mm with surgical sutures, and wrap it on a metal rod of an appropriate size. The metal rod was used as the receiving end of the electrospinning equipment and rotated evenly at a speed of 50 r / min. The prepared 20% polyurethane solution was electrospun. The spinning voltage is 12kV; the receiving distance is 20cm. After spinning is complete, the artificial vascular product is removed from the metal rod. Put the spun artificial blood vessel on the polyurethane rod of corresponding diameter, spunlace the artificial blood vessel with a special acupuncture mold, and rotate the artificial blood vessel to ensure uniform puncture.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract

The invention discloses an artificial blood vessel, a preparation method thereof and an acupuncture mold. The preparation method comprises the following steps: cutting the fabric and sewing the fabric into a cylindrical shape to form the inner wall of the blood vessel; Set on the metal rod, use the metal rod as the receiving end of electrospinning, and perform electrospinning so that the nanofibers evenly adhere to the outer surface of the inner tube wall; when the nanofibers reach the preset thickness, stop spinning, Form the outer wall of the blood vessel, remove the artificial blood vessel from the metal rod; put the artificial blood vessel on the elastic rod, puncture the artificial blood vessel, and make the outer spinning layer and the inner layer firmly combined. The artificial blood vessel provided by the invention can improve the penetration resistance and mechanical strength of the artificial blood vessel, and has the characteristics of anti-deformation and high durability.

Description

technical field [0001] The invention relates to an implantable medical device, in particular to an artificial blood vessel, a preparation method thereof and a puncture mold. Background technique [0002] At present, cardiovascular disease and peripheral arterial disease are the main causes of human death in the world. Approximately 600,000 vascular grafts are performed each year, but nearly one-third of patients cannot use autologous blood vessels because of vascular aging, vascular disease, injury or previous surgical use. In this case, the use of artificial blood vessels has become a good choice. In the 1950s, since people observed the phenomenon of cells growing on silk immersed in blood, the history of fabricating artificial blood vessels began. Today, textile artificial blood vessels have been widely used clinically to replace damaged blood vessels in the human body, and have achieved good clinical results. But at the same time, textile artificial blood vessels also ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/07D04H1/728D04H1/76
Inventor 陈大凯杜广武丁峰罗七一
Owner ACCUPATH MEDICAL JIAXING CO LTD
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