Microcapsule containing functionalized graphene in capsule wall and preparation method of microcapsule

A technology of thiolated graphene and microcapsules, which is applied in the field of biomedical materials, can solve the problems of limited practical applicability, cumbersome operation process, and easy introduction of impurities, and achieves pure and non-toxic products, wide sources of materials, and fast and simple preparation methods Effect

Inactive Publication Date: 2016-02-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the operation process of these methods is cumbersome, time-consuming, and it is easy to introduce impurities, etc., which limi...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 5 mg of graphene oxide was ultrasonically dispersed in dimethylformamide, and an aqueous solution containing 20 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride was added; 2 Under protection, add 10 mg of 4-amino-3-hydrazine-5-mercapto-1,2,4-triazole, stir and react for 2 hours under anaerobic conditions, centrifuge and wash 3 times to remove unreacted 4 -Amino-3-hydrazine-5-mercapto-1,2,4-triazolene to obtain mercaptolated graphene; the prepared mercaptolated graphene is evenly dispersed in deionized water; : 1 Measure the aqueous solution containing mercaptographene and the methyl silicone oil containing lomustine, and place it in an ice-water bath; place the ultrasonic probe at the oil / water two-phase interface, and irradiate with ultrasonic waves under 400W power 5min; the reaction solution was centrifuged and washed to obtain functionalized graphene microcapsules.

Embodiment 2

[0027] 10mg of graphene oxide was ultrasonically dispersed in dimethylformamide, and 50mg of diisopropylcarbodiimide was added; 2 Under protection, 20 mg of 2-amino-5-mercapto-1,3,4-thiadiazole was added, stirred and reacted for 8 hours under anaerobic conditions, centrifuged and washed 5 times, and unreacted 2-amino-5-mercapto-1,3,4-thiadiazole was removed. 1,3,4-thiadiazole to obtain mercaptolated graphene; the prepared mercaptolated graphene is evenly dispersed in deionized water; measure the aqueous solution containing mercaptolated graphene and the thiolated graphene containing Put the sunflower oil of Mustin in an ice-water bath; put the ultrasonic probe on the oil / water two-phase interface, and irradiate the ultrasonic wave for 18 minutes under the power of 300W; centrifuge and wash the reaction solution to obtain functionalized graphene Microcapsules.

Embodiment 3

[0029] 5mg graphene oxide was ultrasonically dispersed in dimethylformamide, and 20mg of dicyclohexylcarbodiimide was added; 2 Under protection, add 20 mg of cysteamine, stir and react for 12 hours under anaerobic conditions, centrifuge and wash 3 times to remove unreacted cysteamine to obtain mercaptographene; disperse the prepared mercaptographene evenly in deionized In water; use a test tube to measure the aqueous solution containing mercaptographene and the fish oil containing paclitaxel at a volume ratio of 10:1, and place it in an ice-water bath; place the ultrasonic probe at the oil / water two-phase interface, and under 100W power, Ultrasonic irradiation for 20 min; the reaction solution was centrifuged and washed to obtain functionalized graphene microcapsules.

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Abstract

The invention relates to a microcapsule containing functionalized graphene in a capsule wall and a preparation method of the microcapsule. In the microcapsule, a crosslinked membrane of sulfhydrylized graphene obtained by modifying a compound which simultaneously contains sulfhydryl and amino or bio-molecules is used as the capsule wall, and an oil phase which is loaded with hydrophobic drugs is used as a core material. The preparation method is achieved by ultrasonically radiating a water solution containing the sulfhydrylized graphene and the oil phase which is loaded with the hydrophobic drugs so as to obtain the microcapsule which contains the functionalized graphene in the capsule wall. The microcapsule disclosed by the invention is capable of achieving the controlled release of the drugs on the basis of the reducing responsiveness of a disulfide bond; and the preparation method is simple to operate, efficient and rapid and high in drug loading capacity, and the preparation method is not easy to introduce impurities, widely applicable to the cladding of the hydrophobic drugs and excellent in application prospect.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a microcapsule whose capsule wall contains functionalized graphene and a preparation method. Background technique [0002] Microcapsules are micro-containers or packages with a specific geometric structure. Due to their special structure and variability in performance, they are widely used in the fields of agriculture, food and biomedicine. There are various materials for preparing microcapsules, mainly including natural polymer materials, synthetic polymer materials and inorganic compounds. There are many methods for preparing microcapsules, which can be roughly divided into three categories according to the mechanism of encapsulation: physical method, physicochemical method and chemical method. In recent years, some new microencapsulation techniques have emerged, such as surface grafting, template polymerization, and layer-by-layer self-assembly. These technologies are all microencaps...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/04A61K31/337A61K31/357A61K31/4745A61K31/17
Inventor 崔学军董林林王洪艳
Owner JILIN UNIV
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