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Medical adhesives and preparation method thereof

A technology of adhesive and sodium alginate, which is applied in chemical modification and medical fields, can solve problems such as insufficient elasticity of organ surface tension, inapplicable tissue bonding, secondary risk of patients, etc., achieve shortened gel time, and the preparation method Convenience, Inexpensive Effects

Active Publication Date: 2016-02-17
莫秀梅 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, α-cyanoacrylate adhesives are not suitable for tissue bonding in vivo because the bonding site is too hard, the elasticity of the surface tension of the organ is not enough, and formaldehyde will be generated after curing, which will cause inflammation. The mixture is a kind of adhesive that has been commercialized and applied clinically, but the components of fibrin, fibrin and thrombin, are extracted from human blood, so there is a risk of virus infection, and it is easy to bring secondary symptoms to patients. secondary risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Accurately weigh 3.96g of sodium alginate and dissolve it in 400ml of deionized water to form a uniform solution. Dissolve 4.28g of sodium periodate in an appropriate amount of deionized water in the dark, then add the sodium periodate solution dropwise into the uniform sodium alginate solution in the dark, and react at room temperature for 4 hours in the dark. The product was put into a dialysis bag (MWCO: 14000) for dialysis for 3 days, and the water was changed every 4 hours.

[0035] The product was poured into a plate and pre-frozen in a -80°C refrigerator for 6 hours, then put into a freeze dryer, and freeze-dried to obtain formylated sodium alginate.

Embodiment 2

[0037]Accurately weigh 5g of porcine gelatin and dissolve it in 100ml of aqueous solution, add 16ml of ethylenediamine, adjust the pH to 5.0, add 0.66g of water-soluble carbodiimide EDC, and react overnight at 37°C. After cooling to room temperature, the product was put into a dialysis bag (molecular weight cut-off: 3500) for dialysis for 3 days, and the water was changed every 4 hours. The product was poured into a plate and pre-frozen in a -80° C. refrigerator for 6 hours, and then put into a freeze dryer to obtain aminated carboxymethyl chitosan.

Embodiment 3

[0039] Formaldehyde alginic acid was made into a solution with a concentration of 30%. Accurately weigh the aminated carboxymethyl chitosan, and prepare a 6% solution with deionized water. Take 1ml of aminated carboxymethyl chitosan solution with a 2ml needle, take 1ml of alginate sodium alginate solution with a 2ml needle, connect the aminated carboxymethyl chitosan solution and the aldehyde The sodium alginate solution is injected into two pieces of 1cm×3cm pigskin by a needle at the same time, so that the two pieces of skin are bonded together, and the bonding strength is 10gfcm -2 , gel time 130 seconds.

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Abstract

The invention relates to medical adhesives and a preparation method thereof. The adhesives are prepared from aldehyde sodium alginate and amination carboxymethyl chitosan. The preparation method includes the steps of mixing equal volumes of aldehyde sodium alginate solution with concentration of 10-50 wt% and amination carboxymethyl chitosan solution with concentration of 1-6 wt%, conducting a Schiff base reaction to form hydrogel, and obtaining the medical adhesives. Selected aldehyde sodium alginate and amination carboxymethyl chitosan are both natural biological materials, are free of toxin and odor, quite high in biological compatibility, low in price, safe, reliable, capable of being locally sprayed or injected to any part of a body in situ and low in cost, and is ideal substitute goods for fibrin glue sold on the market. The preparation method is simple.

Description

technical field [0001] The invention belongs to the fields of chemical modification and medical use, and in particular relates to a medical adhesive and a preparation method thereof. Background technique [0002] According to statistics, more than 12 million patient wounds need to be treated every year. In trauma surgery, the traditional method is to use mechanical connectors (such as: sutures, bone nails, etc.). But they themselves cause damage to surrounding tissue and are not suitable for complex surgeries. In view of these deficiencies, the emergence of medical adhesives has attracted widespread attention for its unique advantages. Compared with sutures, adhesives can effectively stop bleeding, are convenient to use, reduce operation time, do not need to remove sutures to avoid secondary damage caused by sutures, etc. In recent years, with the rapid development of modern medicine and the inclination of policies, the governments of developed countries strongly encourag...

Claims

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Application Information

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IPC IPC(8): A61L24/08
Inventor 莫秀梅袁柳吴俣哈尼.艾-哈姆沙瑞
Owner 莫秀梅
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