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Preparation process and application of carboxymethyl pachymaran

A technology of carboxymethyl tuckahoe polysaccharide and carboxymethyl tuckahoe, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, antineoplastic drugs, etc., can solve the problems of many production steps, many operation steps, and high temperature, and achieve Less consumption of reagents, good water solubility and short use time

Active Publication Date: 2016-02-24
多糖博士生物科技(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two processes require secondary alkalization and ethanol reaction system, and there are many operation steps and consume a large amount of ethanol
[0008] To sum up, in the existing literature reports, the preparation of carboxymethylpachyran has many production steps, large volume of reaction solvent, many types of reagents, high temperature and strict control requirements. The cost of environmental protection is relatively high, and it is not suitable for production and application in the food / health food industry

Method used

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  • Preparation process and application of carboxymethyl pachymaran
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  • Preparation process and application of carboxymethyl pachymaran

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A preparation technology of carboxymethyl pachyrhin, comprising the following steps:

[0032] (1) Preparation of Poria cocos lye: 40kg Poria cocos slices are smashed with a pulverizer, cross a 20 mesh sieve, add 120kg of tap water and soak in a tank mixer for 4 hours, then slowly add 40kg of solid sodium hydroxide, while stirring continuously, Utilize the heat of alkali dissolution to accelerate the dissolution to prepare Poria cocos lye;

[0033] (2) Decolorization and substitution reaction: transfer the Poria base solution from the tank mixer to a mixing hot and cold tank with stirring, start stirring, then slowly add 20kg hydrogen peroxide (35%) for decolorization until the solution turns white. Then slowly add 20kg of solid chloroacetic acid into the poria cocoine solution, turn on the cooling system, control the temperature of the solution not to exceed 60°C, and replace for about 5 hours;

[0034] (3) Neutralization and alcohol precipitation: add 600kg of 95% alc...

Embodiment 2

[0038] A preparation technology of carboxymethyl pachyrhin, comprising the following steps:

[0039] (1) Prepare Poria cocos lye: 40kg Poria cocos slices are smashed with pulverizer, cross 20 mesh sieves, add tap water 80kg and soak in tank mixer for 10 hours, then slowly add solid potassium hydroxide 120kg, keep stirring simultaneously, Utilize the heat of alkali dissolution to accelerate the dissolution to prepare Poria cocos lye;

[0040] (2) Decolorization, substitution reaction: transfer the Poria base solution from the tank mixer to the mixed hot and cold cylinder with stirring, start stirring, then slowly add 26kg hydrogen peroxide (35%) for decolorization until the solution turns white. Then slowly add 40kg of solid chloroacetic acid into the poria cocoine solution, turn on the cooling system, control the temperature of the solution not to exceed 60°C, and replace for about 2 hours;

[0041] (3) Neutralization and alcohol precipitation: add 1200kg of 85% alcohol and 1...

Embodiment 3

[0044] A preparation technology of carboxymethyl pachyrhin, comprising the following steps:

[0045] (1) Prepare Poria cocos lye: 40kg Poria cocos slices are smashed with pulverizer, cross 20 mesh sieves, add tap water 80kg and soak in tank mixer for 12 hours, then slowly add solid sodium hydroxide 80kg, keep stirring simultaneously, Utilize the heat of alkali dissolution to accelerate the dissolution to prepare Poria cocos lye;

[0046] (2) Decolorization and substitution reaction: transfer the Poria base solution from the tank mixer to a mixing hot and cold cylinder with stirring, start stirring, then slowly add 10kg hydrogen peroxide (35%) for decolorization until the solution turns white. Then slowly add 8kg of solid chloroacetic acid into the poria cocoine solution, turn on the cooling system, control the temperature of the solution not to exceed 60°C, and replace for about 10 hours;

[0047] (3) Neutralization and alcohol precipitation: add 900kg of 85% alcohol and 120k...

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Abstract

The invention provides a preparation process of carboxymethyl pachymaran. The preparation process comprises three steps, namely poria cocos lye preparation, a decolouration and substitution reaction and alcohol precipitation; the preparation process is mainly characterized in that an alkalization reaction and an aqueous phase reaction are conducted simultaneously, the decolouration and substitution reaction is conducted continuously, and neutralization and alcohol precipitation are conducted integrally. The preparation process is short in consumed time, little in reagent consumption and low in emission. The prepared carboxymethyl pachymaran has the functions of enhancing immunity and assisting in tumor inhibition when being taken at a low taking dosage.

Description

【Technical field】 [0001] The invention relates to a preparation process and application of carboxymethyl pachyranan, in particular to a preparation process and application of carboxymethyl pachyan with biological activity, and belongs to the field of polymer polysaccharides. 【Background technique】 [0002] Poria cocos [Poriacocos (Schw.) Wolf] is the dry sclerotia of Polyporaceae fungus Poria cocos, is one of the "four monarchs and eight treasures" of traditional Chinese medicine, and has the functions of oozing dampness, invigorating the spleen, and diuresis. β-Poria cocosan accounts for about 93% of the sclerotia of Poria cocos, and the main structure of pachymansan is (1-3)-β-D-glucan with a small amount of β(1-6) branches, but it has almost no resistance. role of tumor [1] . Chihara et al. tried to use selective oxidation method to cut off the β(1-6) branch chain in β-poria cocos polysaccharide, and after moderate hydrolysis, obtained β-poria cocos polysaccharide which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P37/04A61P35/00
CPCA61K31/715C08B37/00C08B37/0003
Inventor 徐晓飞
Owner 多糖博士生物科技(广州)有限公司
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