Blood purification adsorbent and preparation method thereof

A blood purification and adsorbent technology, applied in chemical instruments and methods, and other chemical processes, can solve problems such as poor biocompatibility, achieve low cost, improve envelope stability, and easily obtain raw materials

Active Publication Date: 2016-02-24
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the poor biocompatibility of the blood purification adsorbent in the prior art, the main

Method used

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  • Blood purification adsorbent and preparation method thereof
  • Blood purification adsorbent and preparation method thereof
  • Blood purification adsorbent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] The suspension polymerization step is carried out: first, 50 parts by mass of styrene, 50 parts by mass of divinylbenzene, 100 parts by mass of toluene, and 0.8 parts by mass of benzoyl peroxide are mixed to form an oil phase. The oily phase was then added to a water phase consisting of 0.5 parts by mass of polyvinyl alcohol and 400 parts by mass of water. Then, suspension polymerization was carried out at 80° C. for 5 hours (hours), and the porogen in the resin obtained by polymerization was removed to obtain an adsorption resin (styrene resin).

[0095] Perform the RAFT polymerization step: first add N,N-dimethylethylacrylamide ammonium chloride, 2-acrylamide-2-methylpropanesulfonate in a molar ratio of 1:0.5:0.001:0.01:0.1 to the reaction vessel Acid, RAFT reagent 4-cyanovaleric acid dithiobenzoic acid, initiator 4,4-azo (4-cyanovaleric acid) (V-501) and purified water, stirred to dissolve. Then react under the condition of heating at 70° C. for 2 hours to obtain a ...

Embodiment 2

[0101] The suspension polymerization step is carried out: firstly, 50 parts by mass of styrene, 50 parts by mass of divinylbenzene, 150 parts by mass of toluene, 150 parts by mass of isooctane, and 0.8 parts by mass of benzoyl peroxide are mixed to form an oil phase. The oil phase was then added to a water phase consisting of 1.0 parts by mass of gelatin and 420 parts by mass of water. Then, the suspension polymerization reaction was carried out at a temperature of 90° C. for 4 hours, and the porogen in the resin obtained by polymerization was removed to obtain an adsorption resin (styrene-based resin).

[0102] Perform the RAFT polymerization step: first add 2-methacryloyloxyethyltrimethylammonium chloride, 2-acrylamido-2-methyl Propanesulfonic acid, RAFT reagent 4-cyanovaleric acid dithiobenzoic acid, initiator 4,4-azo(4-cyanovaleric acid) (V-501) and purified water were stirred and dissolved. Then react under heating condition at 75° C. for 2 hours to obtain a polymer inte...

Embodiment 3

[0108] Execute the suspension polymerization step: first, mix 40 parts by mass of styrene, 10 parts by mass of ethylstyrene, 50 parts by mass of divinylbenzene, 150 parts by mass of toluene, 50 parts by mass of gasoline, and 0.8 parts by mass of benzoyl peroxide to form oily phase. The oily phase was then added to a water phase consisting of 7 parts by mass of polyacrylamide and 700 parts by mass of water. Then, suspension polymerization was carried out for 6 hours at a temperature of 60° C., and the porogen in the resin obtained by polymerization was removed to obtain an adsorption resin (styrene-based resin).

[0109] Perform the RAFT polymerization step: first add methacrylamidopropyldimethylamine and 2-acrylamido-2-methylpropanecarboxylic acid in a molar ratio of 1:1:0.1:0.01:5 to the reaction vessel, RAFT Reagent 4-cyanovaleric acid dithiobenzoic acid, initiator 4,4-azo (4-cyanovaleric acid) (V-501) and distilled water, stirred to dissolve. Then react under heating cond...

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Abstract

The invention relates to a blood purification adsorbent and a preparation method thereof. The blood purification adsorbent comprises polystyrene resin and at least one mixed charge polymer in covalent coupling with the polystyrene resin, wherein the mixed charge polymer has an enveloping function on the polystyrene resin and comprises multiple repetitive units. The preparation method mainly comprises a polymer suspension step, an RAFT (reversible addition-fragmentation transfer) polymerization step, a reduction step and a coupling grafting step. According to the blood purification adsorbent and the preparation method thereof, the mixed charge amphoteric polymer is utilized to envelop the polystyrene resin, so that the polystyrene adsorbent resin surface has excellent hydrophilic performance, and the efficient blood compatibility of the adsorbent resin is achieved.

Description

technical field [0001] The invention relates to an adsorbent for blood purification and a preparation method thereof, in particular to a membrane adsorbent containing mixed charge zwitterions and a preparation method thereof. Background technique [0002] Hemoperfusion is the use of power to lead the patient's blood to the extracorporeal circulation, and remove the endogenous or exogenous poisons or pathogenic substances in the patient's blood through the adsorbent with special adsorption function in the hemoperfusion device, so as to achieve blood purification. A healing technique. [0003] The key to the development of hemoperfusion technology is to prepare adsorbent materials with good hemocompatibility, strong adsorption performance, high selectivity or high specificity. At present, the commonly used adsorbent materials for hemoperfusion mainly include activated carbon, natural modified polymers, synthetic polymers and inorganic materials. Among them, highly cross-link...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08F212/08C08F212/36C08F212/12C08F226/02C08F220/58C08F112/36B01J20/26B01J20/30
CPCB01J20/264B01J20/30C08F112/36C08F212/08C08F212/36C08F220/58C08F226/02C08G81/021C08F212/12C08F220/06
Inventor 董凡刘云鸿
Owner JAFRON BIOMEDICAL
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