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Method for recycling phenylglycine in cefalexin crystallization mother liquid

A technology of phenylglycine and crystallization mother liquor, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry and other directions, can solve problems such as non-recovery, large consumption of organic solvents, waste of resources, etc., and is conducive to environmental protection and COD emission. Low, lower processing cost effect

Active Publication Date: 2016-02-24
XIAMEN TQX MEMBRANE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The current solution for the treatment of cephalexin mother liquor is to use organic solvents for extraction and chelation to extract cephalexin. This method not only wastes phenylglycine, but also consumes a lot of organic solvents, which cannot be discharged to environmental protection for biochemical treatment. Solid waste can only be formed by evaporation. Reprocessing solid waste, this method is too costly and a waste of resources
[0003] Patent application CN103788115A discloses a method for concentrating cephalexin by an integrated membrane method and a concentrated enzyme method. Through fine filtration, ultrafiltration membrane, nanofiltration and reverse osmosis, the original cephalexin solution is concentrated more than 10 times, but it only reaches For the purpose of concentration, there is no specific method for how to deal with the concentrated solution; patent CN104058537B discloses a method for treating wastewater from cephalexin enzymatic synthesis of mother liquor, which can only recycle water and inorganic salt crystals in the mother liquor, and there are still other value components of which cannot be recovered

Method used

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  • Method for recycling phenylglycine in cefalexin crystallization mother liquid

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Experimental program
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Effect test

Embodiment 1

[0031] Take 100L of enzymatic cephalexin crystallization mother liquor, wherein the cephalexin content is 15-18g / L, add 10kg of penicillin G acylase to it, adjust pH=7, and react for 2h at a temperature of 40°C to crack it to obtain Lysis solution of 7-aminodesacetoxycephalosporanic acid and phenylglycine, wherein phenylglycine is 15-18g / L, cephalexin content is less than 1g / L, ammonium sulfate is about 100g / L, conductivity is about 10ms / cm, Biochemical oxygen consumption (COD) is about 200000mg / L, ammonia nitrogen (NH 3 -N) is about 30000mg / L, pH=6-7. Use dilute sulfuric acid to adjust the pH of the lysate to pH=4, and keep the temperature at 30° C. for later use.

[0032] Take 100L of the lysate and carry out centrifugation at a speed of 4000r / min to obtain 1.02kg of 7-aminodesacetoxycephalosporanic acid crystals and about 100L of the centrifuged liquid, which is filtered through a 2KDa-20KDa roll-type ultrafiltration membrane. The operating pressure is 3bar and the temper...

Embodiment 2

[0036]Take 100 L of enzymatic cephalexin crystallization mother liquor, wherein the cephalexin content is 15-18 g / L, add 10 kg of penicillin G acylase to it, adjust pH=5 with dilute sulfuric acid, and react for 5 hours at a temperature of 25° C. to make it Cleavage to obtain a lysate containing 7-aminodesacetoxycephalosporanic acid and phenylglycine, wherein the phenylglycine is 15-18g / L, the cephalexin content is less than 1g / L, the ammonium sulfate is about 100g / L, and the conductivity is about 10ms / cm, biochemical oxygen consumption (COD) is about 200000mg / L, ammonia nitrogen (NH 3 -N) is about 30000mg / L, pH=6-7. Use dilute sulfuric acid to adjust the pH of the lysate to pH=3, and keep the temperature at 25° C. for later use.

[0037] Take 100L of the lysate and carry out centrifugation at a speed of 8000r / min to obtain 1.35kg of 7-aminodesacetoxycephalosporanic acid crystals and about 100L of the centrifuged liquid. The centrifuged liquid is filtered through a roll-type ...

Embodiment 3

[0041] Take 100L of enzymatic cephalexin crystallization mother liquor, wherein the cephalexin content is 15-18g / L, add 10kg of penicillin G acylase to it, adjust the pH=9 with diluted ammonia water, and react for 1h at a temperature of 50°C. Make it crack to obtain the lysate containing 7-aminodesacetoxy cephalosporanic acid and phenylglycine, wherein phenylglycine 15-18g / L, cephalexin content is less than 1g / L, ammonium sulfate is about 100g / L, conductivity is about 10ms / cm, biochemical oxygen consumption (COD) is about 200000mg / L, ammonia nitrogen (NH 3 -N) is about 30000mg / L, pH=6-7. Use dilute sulfuric acid to adjust the pH of the lysate to pH=4, and keep the temperature at 30° C. for later use.

[0042] Get 100L of lysate and carry out centrifugation, rotating speed is 5000r / min, obtain 7-aminodesacetoxy cephalosporanic acid crystal 1.02kg and centrifuged liquid about 100L, centrifuged liquid is through membrane filtration (membrane core is roll type ultrafiltration mem...

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Abstract

The invention relates to a method for recycling phenylglycine in cefalexin crystallization mother liquid. The method comprises the steps of pyrolysis, centrifugation, pretreatment, desalination and nano-filtration concentration. The method provided by the invention solves the difficulty that wastewater containing cefalexin cannot be directly treated biochemically, and phenylglycine recovered by the method can be directly applied to subsequent production. According to the method disclosed by the invention, an organic solvent is not used, and the production cost is reduced, so that the method is beneficial for environmental protection and is a green and efficient recovery method.

Description

technical field [0001] The invention relates to a process for recycling organic mother liquor, in particular to a method for recycling phenylglycine in cephalexin crystallization mother liquor. Background technique [0002] Cephalexin is a broad-spectrum antibiotic. The cephalexin mother liquid wastewater produced during its production process contains a large amount of organic matter, inorganic salts and a small amount of cephalexin products. This kind of organic waste water with high salt content is difficult to use conventional biochemical methods. Or simple nanofiltration treatment and recovery. The current solution for the treatment of cephalexin mother liquor is to use organic solvents for extraction and chelation to extract cephalexin. This method not only wastes phenylglycine, but also consumes a lot of organic solvents, which cannot be discharged to environmental protection for biochemical treatment. Solid waste can only be formed by evaporation. The cost of reproc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P35/02C12P13/04C07C229/36C07C227/40C07D501/22C07D501/12
CPCC07C227/40C07D501/12C07D501/22C12P13/04C12P35/02C07C229/36
Inventor 吴洪溪
Owner XIAMEN TQX MEMBRANE TECH
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