Determination method and application of osteoporosis serum metabolic marker

An osteoporosis and measurement method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of difficult early diagnosis of clinical patients and slow osteoporosis, and achieve a simple measurement method, less patient damage, and high sensitivity. Effect
CN105353047AInactive Publication Date: 2016-02-24NANJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF TECH
Publication Date
2016-02-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a determination method and application of normal and different osteoporosis pathological process human serum difference metabolites. First, premenopause and post-menopause normal, osteopenia and osteoporosis patient serum are collected, serum metabolic compound original data is obtained by gas chromatography mass spectrometry analysis technique, SIMCAP-11 software is used to establish a multi-dimensional statistical model to find and identify serum difference metabolites in premenopause bone mass normal and post-menopause bone mass normal and bone mass initiation loss patients and osteoporosis patients, a plurality of difference metabolites in higher correlation with the osteoporosis pathological process can be further determined by use of correlation analysis and ROC curve analysis, a technical support for the early diagnosis and prevention of osteoporosis is provided, and patients in the early osteoporosis stage in which most of the physiological and biochemical indexes are not clear can be alerted.
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Description

technical field

[0001] The invention relates to a measurement method and application of metabolic markers in serum of women with osteoporosis before and after menopause. It specifically involves the determination of metabolic small molecular substances in human serum by gas chromatography, and the analysis of premenopausal normal group (group I), osteopenia group (group II), osteoporosis patient group (group III) and postmenopausal normal group. (Group IV) Differential metabolite profiles between serum, looking for differential metabolic compounds related to the pathological process of osteoporosis, and providing technical support for the early stage and diagnosis of osteoporosis. Background technique

[0002] Osteoporosis is a metabolic bone disease characterized by decreased bone mass, destruction of bone tissue microstructure, increased bone fragility, and increased incidence of fractures. Postmenopausal osteoporosis is a disease with high incidence in postmenopausal wom...

Claims

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