Determination method and application of osteoporosis serum metabolic marker

An osteoporosis and measurement method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of difficult early diagnosis of clinical patients and slow osteoporosis, and achieve a simple measurement method, less patient damage, and high sensitivity. Effect

Inactive Publication Date: 2016-02-24
NANJING UNIV OF TECH
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Problems solved by technology

However, the occurrence of osteoporosis is very slow, and the change is not obvious in a short period of time. It requires long-term observation and continuous detection. Once bone loss is found, the decrease in bone density is difficult to reverse, which brings great benefits to the early diagnosis of clinical patients. come with great difficulty

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  • Determination method and application of osteoporosis serum metabolic marker
  • Determination method and application of osteoporosis serum metabolic marker
  • Determination method and application of osteoporosis serum metabolic marker

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Embodiment Construction

[0024] The present invention is described in detail through examples.

[0025] (1) Collect samples

[0026] According to the diagnostic criteria recommended by the World Health Organization (WHO), bone mineral density decreased by 1 to 2.5 standard deviations as the osteopenia group, and the decrease was equal to or greater than 2.5 standard deviations as the osteoporosis group. Based on the above criteria, blood samples were collected from four experimental groups of premenopausal normal bone mass, postmenopausal normal bone mass, osteopenia and osteoporosis in the age group of 50 to 70 years old. During sample collection, the exclusion criteria were as follows:

[0027] a): Patients with diseases known to affect calcium or bone metabolism, such as severe malabsorption syndrome, inflammatory bowel disease, chronic liver disease, alcoholic cirrhosis, uncontrolled primary hyperparathyroidism or thyroid disease, Paget's bone disease, osteomalacia, etc.

[0028] b): secondary ...

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Abstract

The present invention discloses a determination method and application of normal and different osteoporosis pathological process human serum difference metabolites. First, premenopause and post-menopause normal, osteopenia and osteoporosis patient serum are collected, serum metabolic compound original data is obtained by gas chromatography mass spectrometry analysis technique, SIMCAP-11 software is used to establish a multi-dimensional statistical model to find and identify serum difference metabolites in premenopause bone mass normal and post-menopause bone mass normal and bone mass initiation loss patients and osteoporosis patients, a plurality of difference metabolites in higher correlation with the osteoporosis pathological process can be further determined by use of correlation analysis and ROC curve analysis, a technical support for the early diagnosis and prevention of osteoporosis is provided, and patients in the early osteoporosis stage in which most of the physiological and biochemical indexes are not clear can be alerted.

Description

technical field [0001] The invention relates to a measurement method and application of metabolic markers in serum of women with osteoporosis before and after menopause. It specifically involves the determination of metabolic small molecular substances in human serum by gas chromatography, and the analysis of premenopausal normal group (group I), osteopenia group (group II), osteoporosis patient group (group III) and postmenopausal normal group. (Group IV) Differential metabolite profiles between serum, looking for differential metabolic compounds related to the pathological process of osteoporosis, and providing technical support for the early stage and diagnosis of osteoporosis. Background technique [0002] Osteoporosis is a metabolic bone disease characterized by decreased bone mass, destruction of bone tissue microstructure, increased bone fragility, and increased incidence of fractures. Postmenopausal osteoporosis is a disease with high incidence in postmenopausal wom...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 张琪祁欢欢马博李静朱建伟
Owner NANJING UNIV OF TECH
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