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Preparation method of protein-starch compound disintegrating agent

A technology for compounding disintegrants and proteins, which can be applied to non-active medical preparations, pharmaceutical formulations, non-active components of polymer compounds, etc., and can solve the problems of inability to improve the thermal stability of the compound and insignificant steric hindrance effect.

Active Publication Date: 2016-03-02
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the polysaccharide chain is too short, the steric hindrance effect is not obvious, and the thermal stability of the complex cannot be improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0012] A method for preparing a protein-starch composite disintegrant, the method comprising the following steps: (1) defatting soybean protein isolate with 95% ethanol solution for 2 hours to obtain defatted soybean protein; (2) placing mung bean starch in continuous Superfine pulverization is carried out in a superfine pulverizer with circulating cooling equipment, the superfine pulverization power is 800-1200W, the superfine pulverization time is 2-10min, and the cooling temperature is -20°C to obtain superfine pulverization mung bean starch; (3) Add water and mix the defatted soybean protein and the ultra-finely pulverized mung bean starch, the mass ratio of the defatted soybean protein and the ultra-finely pulverized mung bean starch is 1:5, after mixing, perform high-pressure homogenization to obtain a uniform mixed solution; (4) Pour the mixed solution into a round top flask, install a reflux device, and place it in a microwave reactor for reflux microwave heating treatm...

Embodiment 1

[0016] Use 95% ethanol solution to degrease soybean protein isolate for 2 hours to obtain defatted soybean protein. Put mung bean starch in an ultrafine pulverizer connected with circulating cooling equipment, and conduct the degreasing under the condition of power of 1100W and cooling temperature of -20°C. Ultrafine grinding for 6 minutes to obtain ultrafine grinding mung bean starch; mix defatted soybean protein and ultrafine grinding mung bean starch at a ratio of 1:5, dissolve in water, perform high-pressure homogenization after mixing to obtain a uniform mixed solution, pour the mixed solution Put it into a round top flask, install a reflux device, place it in a microwave reactor, and carry out a reflux microwave heating treatment for 20 minutes under the conditions of a microwave power of 300W and a microwave temperature of 90°C, and then freeze-dry to obtain a protein-starch composite Disintegrant. The protein-starch complex has good disintegration performance, and has ...

Embodiment 2

[0018] Use 95% ethanol solution to degrease soybean protein isolate for 2 hours to obtain defatted soybean protein. Put the mung bean starch in an ultrafine pulverizer connected with circulating cooling equipment, and conduct the degreasing under the condition of power of 1000W and cooling temperature of -20°C. Ultrafine grinding for 8 minutes to obtain ultrafine grinding mung bean starch; mix defatted soybean protein and ultrafine grinding mung bean starch at a ratio of 1:5 and dissolve in water, perform high-pressure homogenization after mixing to obtain a uniform mixed solution, pour the mixed solution Put it into a round top flask, install a reflux device, place it in a microwave reactor, and carry out a reflux microwave heating treatment for 15 minutes under the conditions of a microwave power of 400W and a microwave temperature of 85°C, and then freeze-dry to obtain a protein-starch composite Disintegrant. The protein-starch complex has good disintegration performance, a...

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PUM

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Abstract

The invention discloses a preparation method of a protein-starch compound disintegrating agent, and belongs to the technology of processing of a medical solid preparation. The method comprises the following steps: (1) conducting ethanol degreasing on soybean isolate protein so as to obtain degreased soybean protein; (2) implementing superfine grinding on green bean starch in a superfine grinding machine which is connected to circulating cooling equipment, so that superfine-ground green bean starch is obtained; (3) uniformly mixing the degreased soybean protein with the superfine-ground green bean starch with the addition of water, and homogenizing under high pressure, so that a uniform mixed solution is obtained; and (4) pouring the mixed solution to a domed flask, mounting a reflux device, conducting reflux-type microwave heating treatment in a microwave reactor and then conducting freeze-drying, so that the protein-starch compound disintegrating agent is obtained. The method has the characteristics of simple process and low cost, and the prepared protein-starch compound is good in disintegrating performance; meanwhile, the product is relatively good in dissolving property, emulsifying property and oxidation resistance; and the product, as a disintegrating agent, is applicable to the field of medicine.

Description

technical field [0001] The invention belongs to the processing technology of medical solid preparations, and mainly relates to a preparation method of a protein-starch composite disintegrant. Background technique [0002] Starch-protein complex is a high molecular polymer compounded by microwave. As a natural, non-toxic and safe new biological material, it can be widely used in food, medicine, cosmetics and other ranks. Starch and protein are two types of important natural polymers, which are cheap, easy to obtain, degradable and good biocompatibility. For a long time, all countries in the world have attached great importance to the development and utilization of starch and protein resources, especially the modification of starch and protein by various methods has always been a research hotspot. [0003] Compared with potato starch and wheat starch, mung bean starch has the advantages of high viscosity, low water absorption, white and glossy color. And contains a considera...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/36
CPCA61K47/36A61K47/42
Inventor 李杨隋晓楠邹小霜
Owner NORTHEAST AGRICULTURAL UNIVERSITY