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Production method of pharmaceutical-grade calcium carbonate

A production method, calcium carbonate technology, applied in the direction of calcium carbonate/strontium/barium, etc., can solve the problems that affect the grinding efficiency and product quality, high production process requirements, uneven particle size distribution, etc., to reduce the grinding time, The effect of high purity and low cost

Inactive Publication Date: 2016-03-02
SICHUAN YIXIN NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the particularity of its use, pharmaceutical grade calcium carbonate has higher requirements on the production process.
However, the medical calcium carbonate produced by the prior art has shortcomings such as low yield, low purity, and uneven particle size distribution, and there is high energy consumption in the production process, and the fine powder in the slurry is also easy to grind in wet grinding Agglomeration occurs, affecting grinding efficiency and product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: A kind of production method of pharmaceutical grade calcium carbonate, it comprises the following steps:

[0022] S1. Crushing: Wash the marble stones with high-pressure water, remove the soil and dust on the surface of the stones, and then crush them with a crusher until the particle size is ≤40mm;

[0023] S2. homogeneous: add sodium carbonate, dodecyl dimethyl benzyl ammonium chloride to the crushed marble and stir for 20min, the rotating speed of the mixer is 800r / min; the marble, sodium carbonate and dodecyl dimethyl ammonium The weight ratio of benzyl ammonium chloride is 80:1:1;

[0024] S3. Grinding: adding the homogenized marble to a vertical mill for grinding, the vertical mill is provided with a water spray device, spraying water during the grinding process to obtain a powder, the particle size of the powder is 1250 mesh; wherein, the grinding temperature of the vertical mill is 40°C, the grinding pressure is 8MPa, and the moisture control index ...

Embodiment 2

[0027] Example 2: A kind of production method of pharmaceutical grade calcium carbonate, it comprises the following steps:

[0028] S1. Crushing: Wash the marble stones with high-pressure water, remove the soil and dust on the surface of the stones, and then crush them with a crusher until the particle size is ≤40mm;

[0029] S2. Homogeneous: add sodium carbonate, dodecyl dimethyl benzyl ammonium chloride to the crushed marble and stir for 40min, the rotating speed of the mixer is 1200r / min; the marble, sodium carbonate and dodecyl dimethyl ammonium The weight ratio of benzyl ammonium chloride is 110:5:1;

[0030] S3. Grinding: adding the homogenized marble to a vertical mill for grinding, the vertical mill is provided with a water spray device, spraying water during the grinding process to obtain a powder, the particle size of the powder is 2500 mesh; wherein, the grinding temperature of the vertical mill is 50°C, the grinding pressure is 12MPa, and the moisture control in...

Embodiment 3

[0033] Example 3: A kind of production method of pharmaceutical grade calcium carbonate, it comprises the following steps:

[0034] S1. Crushing: Wash the marble stones with high-pressure water, remove the soil and dust on the surface of the stones, and then crush them with a crusher until the particle size is ≤40mm;

[0035] S2. Homogeneous: add sodium carbonate, dodecyl dimethyl benzyl ammonium chloride to the crushed marble and stir for 28min, the rotating speed of the mixer is 1000r / min; the marble, sodium carbonate and dodecyl dimethyl ammonium The weight ratio of benzyl ammonium chloride is 90:2:1;

[0036] S3. Grinding: adding the homogenized marble to a vertical mill for grinding, the vertical mill is provided with a water spray device, spraying water during the grinding process to obtain a powder, the particle size of the powder is 2000 mesh; wherein, the grinding temperature of the vertical mill is 42°C, the grinding pressure is 9MPa, and the moisture control inde...

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PUM

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Abstract

The invention discloses a production method of pharmaceutical-grade calcium carbonate. The production method comprises steps of smashing, homogenizing, grinding, modifying, and freeze drying. According to the production method, sodium carbonate and dodecyl dimethyl benzyl ammonium chloride are added in the step of homogenizing so as to increase subsequent grinding efficiency, and shorten grinding time; a water injector is arranged in an adopted grinding miller, sprayed atomized water is capable of increasing powder weight, and suspension of powder is not easily caused, so that a millstone material bed is stabilized, and it is beneficial for grinding via combined action with added sodium carbonate and dodecyl dimethyl benzyl ammonium chloride; the production method is high in pharmaceutical-grade calcium carbonate yield; purity of obtained pharmaceutical-grade calcium carbonate is high, and particle size distribution is uniform; energy cost in production process is low, at the same time aggregation of fine powder in a slurry in wet grinding is not caused; operation of the production method is simple; production is convenient; cost is low; and the production method is suitable for industrialized large-scale production.

Description

technical field [0001] The invention relates to the field of inorganic non-metallic mineral materials, in particular to a production method of pharmaceutical grade calcium carbonate. Background technique [0002] Ground calcium carbonate, also known as ground calcium carbonate, is a powder product made of natural calcite, marble, chalk, etc., which is mechanically crushed and ground to a certain fineness. It is generally called finely ground calcium carbonate (FGCC) internationally. In the paper industry, in order to distinguish between precipitated calcium carbonate, the ratio is abbreviated as GCC and PCC. Generally, products with an average particle size below 12 μm are called heavy fine calcium carbonate to distinguish general heavy calcium carbonate. Calcium carbonate products are divided into special calcium for granite, special calcium for sealant, special calcium for rubber, special calcium for papermaking, special calcium for plastic, special calcium for paint and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/18
Inventor 彭贵明陈华平雷礼强李林富王晓洪
Owner SICHUAN YIXIN NEW MATERIAL CO LTD
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