Biological detection system based on graphene and making and integrating methods thereof

A biological detection system, graphene technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of detection sensitivity drop, achieve the effect of improving accuracy, solving photolithographic alignment problems, and reducing the rate of defective products

Active Publication Date: 2016-03-02
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Problems solved by technology

Patent CN1585896A uses FET sensors to detect ion concentration and base sequence. Since charged ions or base sequences have Debye wavelengths in solution, if the ions and base sequences are relatively far away from the conductive channel, the detection sensitivity will be lower. also dropped sharply

Method used

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  • Biological detection system based on graphene and making and integrating methods thereof
  • Biological detection system based on graphene and making and integrating methods thereof
  • Biological detection system based on graphene and making and integrating methods thereof

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Embodiment Construction

[0037] The invention provides a method for making and integrating a highly sensitive biological and chemical detection system. Fabricate a graphene-based high-sensitivity biosensor through a silicon chip; then design a conditioning circuit to amplify the output signal of the sensor; then use an A / D conversion chip to convert the data and transmit it to a single-chip microcomputer to realize the display of the detection data; finally , using the driving circuit to control the microfluidic channel. The biological detection system made by this method can be used to detect different types of disease-related factors (such as DNA, RNA, protein, etc.), viruses or cells, and has the characteristics of high sensitivity, stability, and easy integration. At the same time, this manufacturing method is compatible with traditional semiconductor processes, and can be mass-produced to facilitate cost reduction.

[0038]Compared with traditional detection equipment, the graphene-based biologi...

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Abstract

The invention provides a high-sensitivity biological detection system based on graphene and making and integrating methods thereof. A high-sensitivity biosensor based on graphene is manufactured based on a silicon wafer firstly, then a conditioning circuit is designed to conduct amplification filtering on a signal output by the biosensor, data are converted and transmitted to a single-chip microcomputer through an A/D conversion chip, detected data are processed with the statistical method, a set of related disease factor risk assessment system is made, a liquid crystal display screen is added to display the disease risk level, and finally a micro-fluid channel is controlled through a driving circuit. The biological detection system made with the method can be used for detecting different types of disease related factors such as DNA, RNA and protein, viruses or cells and has the advantages of being high in sensitivity, stable, easy to integrate and the like.

Description

technical field [0001] The invention relates to a graphene-based biological detection system and a method for manufacturing an integrated graphene-based high-sensitivity biological detection system, in particular to a method for manufacturing an integrated high-sensitivity nanometer device and a measurement system. Background technique [0002] At present, diabetes, cardiovascular disease, respiratory disease, liver disease, and cancer are major diseases that threaten human health. Although medicine and related disciplines continue to develop and progress, people are still making slow progress in the rapid diagnosis and treatment of these diseases; if these diseases cannot be discovered in time, it is almost difficult to treat them when they reach an advanced stage. The reason why the disease cannot be detected early is that, first, in the early stage, the relevant pathogenesis characteristics are not obvious, and the number of related protein factors secreted by it is relat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00G01N33/558
Inventor 杨赢苏瑞巩张宝顺
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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