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Ibuprofen-codeine phosphate compounding preparation and preparation method therefor

A compound preparation, codeine phosphate technology, applied in the directions of anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., can solve the problems of poor sustained release effect and large differences in drug release, and achieve good sustained release effect and little mutual influence. , slow-release effect and the effect of

Active Publication Date: 2016-03-16
XINAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the ibuprofen sustained-release layer in the profencodeine sustained-release double-layer tablet is limited by the preparation method and affected by the codeine phosphate immediate-release layer, so the sustained-release effect is not good and the difference in drug release is large

Method used

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  • Ibuprofen-codeine phosphate compounding preparation and preparation method therefor
  • Ibuprofen-codeine phosphate compounding preparation and preparation method therefor
  • Ibuprofen-codeine phosphate compounding preparation and preparation method therefor

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preparation example Construction

[0069] The present invention also provides a preparation method of the ibuprofen sustained-release pellets described in the above technical scheme, comprising the following steps:

[0070] a) Granulating after mixing codeine phosphate, microcrystalline cellulose, filler and binder, to obtain codeine phosphate immediate-release pellets;

[0071] b) granulating after mixing ibuprofen, disintegrating agent, filler and binding agent to obtain drug-containing pills; the disintegrating agent is microcrystalline cellulose;

[0072] c) coating the drug-containing pill with a sustained-release material to obtain ibuprofen sustained-release pellets; the sustained-release material is polymethacrylate or ethylcellulose;

[0073] d) mixing the ibuprofen sustained-release pellets and codeine phosphate immediate-release pellets to obtain a profen-codeine compound preparation.

[0074] In the present invention, codeine phosphate, microcrystalline cellulose, filler and binder are mixed and gr...

Embodiment 1

[0120] (1) 13g codeine phosphate crude drug, 60gMCCPH302, and 60g starch are stirred and evenly mixed in the HLSH2-6 type wet mixing granulator, and the chassis rotating speed of stirring is 600rpm, and the side disk rotating speed is 1200rpm to obtain the mixed powder; then Keep stirring condition constant, add 71g mass fraction in above-mentioned mixed powder and be 10% starch slurry, obtain soft material; Then above-mentioned soft material is moved to E50 type extruder, extruding under the condition that extrusion speed is 30rpm After 2 minutes, the strips were obtained; then the above-mentioned strips were spheronized in the s-250 type spheronizer for 3 minutes, and the rotating speed of the spheronization was 1200rpm to obtain vegetarian pills; Dry for 12 hours at a drying temperature of 40°C; finally pass through a 18-20 mesh sieve to obtain codeine phosphate immediate-release pellets.

[0121] (2) Stir and mix 200g ibuprofen crude drug, 90gMCCPH302, and 10gLAC in the HL...

Embodiment 2

[0126] (1) Stir 13g of codeine phosphate raw material, 40gMCCPH302, and 80g of calcium hydrogen phosphate in the HLSH2-6 type wet mixing granulator, the chassis rotating speed of stirring is 600rpm, and the side disk rotating speed is 1200rpm to obtain mixed powder Then keep stirring condition constant, add 71g mass fraction in the above-mentioned mixed powder and be 10% PVPK30 aqueous solution, obtain soft material; Then above-mentioned soft material is moved to E50 type extruder, under the condition of 30rpm in extruding speed Extrude for 2 minutes to obtain strips; then spheronize the above-mentioned strips in the s-250 type spheronizer for 3 minutes, and the rotation speed of the spheronization is 1200rpm to obtain vegetarian pills; then put the above-mentioned vegetarian pills in CS101-2ABN hot air circulation Dry in an oven for 12 hours at a drying temperature of 40°C; finally pass through a 18-20 mesh sieve to obtain codeine phosphate immediate-release pellets.

[0127]...

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Abstract

The invention provides an ibuprofen-codeine phosphate compounding preparation. The ibuprofen-codeine phosphate compounding preparation is composed of ibuprofen sustained-release pellets and codeine phosphate quick-release pellets. The ibuprofen sustained-release pellets comprise medicine-containing blank pellets and a sustained-release material coating the surfaces of the medicine-containing blank pellets. The medicine-containing blank pellets comprise the following ingredients, by weight, 55-75 parts of ibuprofen, 15-35 parts of disintegrating agent, 1-15 parts of filler and 1-5 parts of adhesive. The disintegrating agent is microcrystalline cellulose. The sustained-release material is polymethacrylate or ethyl cellulose. The codeine phosphate quick-release pellets comprise the following ingredients, by weight, 1-5 parts of codeine phosphate, 10-30 parts of disintegrating agent, 10-30 parts of filler and 1-5 parts of adhesive. When the ibuprofen-codeine phosphate compounding preparation is compared with the prior art, mutual influences of ibuprofen and codeine phosphate in the ibuprofen-codeine phosphate compounding preparation are small, and the sustained-release effect of ibuprofen is good and stable.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound preparation of profendine and a preparation method thereof. Background technique [0002] Profencodeine is a compound preparation of ibuprofen and codeine phosphate, which is mainly used for analgesia of moderate pain caused by various reasons, such as: cancer pain, postoperative pain, arthralgia, neuralgia, muscle pain, Migraine, headache, dysmenorrhea, toothache, etc. In the profencodeine compound preparation, ibuprofen and codeine phosphate are analgesics with different action mechanisms. Among them, ibuprofen plays a long-acting anti-inflammatory and analgesic effect, which inhibits the production of various prostaglandins related to inflammation by reversibly inhibiting cyclooxygenase, and locally analgesic effects on the inflammatory tissue of the pain source; and phosphoric acid Codeine can quickly play an analgesic effect in the central nervous system, and ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/32A61K31/485A61P29/00A61K31/192
CPCA61K9/0002A61K9/2081A61K31/192A61K31/485A61K47/32A61K2300/00
Inventor 李标蒲道俊周成林朱海游徐洁罗宏向俭贺丽英
Owner XINAN PHARMA
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