Aminated poly-glycidyl methacrylate crosslinked composite microsphere and preparation method as well as application thereof

A polymethacrylic acid, glycidyl ester technology, applied in chemical instruments and methods, alkali metal compounds, inorganic chemistry and other directions, can solve the problems of difficult control of suspension polymerization process conditions, unstable product properties, etc., and is conducive to large-scale production. Application, macroscopically controllable size, simple and easy-to-control process

Active Publication Date: 2016-04-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the suspension polymerization process conditions are not easy to control, making the product properties unstable

Method used

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  • Aminated poly-glycidyl methacrylate crosslinked composite microsphere and preparation method as well as application thereof
  • Aminated poly-glycidyl methacrylate crosslinked composite microsphere and preparation method as well as application thereof
  • Aminated poly-glycidyl methacrylate crosslinked composite microsphere and preparation method as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In this embodiment, the preparation method of aminated polyglycidyl methacrylate crosslinked composite microspheres is as follows:

[0041] (1) Polymerization reaction

[0042] Dissolve 14 parts of polyethersulfone in 86 parts of N,N-dimethylacetamide, heat to 90°C and stir to completely dissolve the polyethersulfone to obtain a polyethersulfone solution, and add methyl Glycidyl acrylate, cross-linking agent N, N'-methylenebisacrylamide and initiator azobisisobutyronitrile, after vacuuming to remove oxygen, nitrogen gas was introduced, and the reaction was stirred under nitrogen protection at 90°C for 24 hours. Stop heating and stirring after the reaction is over, place the reaction solution gained from the reaction for 24 hours and then filter to obtain a filtrate. The resulting filtrate is the preparation solution of polyglycidyl methacrylate crosslinked composite microspheres. Nitrogen gas is passed into the preparation solution of combined composite microspheres fo...

Embodiment 2

[0050] In this embodiment, the preparation method of aminated polyglycidyl methacrylate crosslinked composite microspheres is as follows:

[0051] (1) Polymerization reaction

[0052] Dissolve 10 parts of polyethersulfone in 90 parts of N,N-dimethylacetamide, heat to 60°C and stir to completely dissolve the polyethersulfone to obtain a polyethersulfone solution, and add methyl Glycidyl acrylate, cross-linking agent N, N'-methylenebisacrylamide and initiator azobisisobutyronitrile, after vacuuming to remove oxygen, nitrogen gas was introduced, and the reaction was stirred under nitrogen protection at 60°C for 18 hours. Stop heating and stirring after the reaction is over, place the reaction solution gained from the reaction for 24 hours and then filter to obtain a filtrate. The resulting filtrate is the preparation solution of polyglycidyl methacrylate crosslinked composite microspheres. Nitrogen gas is passed into the preparation solution of combined composite microspheres fo...

Embodiment 3

[0059] In this embodiment, the preparation method of aminated polyglycidyl methacrylate crosslinked composite microspheres is as follows:

[0060] (1) Polymerization reaction

[0061] Dissolve 12 parts of polystyrene in 88 parts of N,N-dimethylacetamide, heat to 60°C and stir to completely dissolve the polystyrene to obtain a polystyrene solution, and add methyl Glycidyl acrylate, cross-linking agent N, N'-methylenebisacrylamide and initiator azobisisobutyronitrile, after vacuuming to remove oxygen, nitrogen gas was introduced, and the reaction was stirred under nitrogen protection at 60°C for 18 hours. Stop heating and stirring after the reaction is over, place the reaction solution obtained from the reaction for 24 hours and then filter to obtain the filtrate, which is the preparation solution of polyglycidyl methacrylate crosslinked composite microspheres;

[0062] When forming the reaction system, the addition of glycidyl methacrylate is 6 parts; the molar ratio of crossl...

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Abstract

The invention relates to an aminated poly-glycidyl methacrylate crosslinked composite microsphere, being of a porous structure prepared from a matrix polymer and aminated poly-glycidyl methacrylatewherein the matrix polymer is a web template, the aminated poly-glycidyl methacrylate are crosslinked into a web of the matrix polymer, and the mass ratio of the matrix polymer to the aminated poly-glycidyl methacrylate is (1 to 3) : 1. The porosity of the composite microsphere is 75-90 percent, and the specific surface area is 7-20m<2> / g. The invention relates to a preparation method of the aminated poly-glycidyl methacrylate crosslinked composite microsphere, comprising the following steps: (1) polymerization reaction; (2) preparation of the poly-glycidyl methacrylate crosslinked composite microsphere; (3) modification of the poly-glycidyl methacrylate crosslinked composite microsphere. A high polymer adsorbent greater in porosity and specific surface area, controllable in size, stable in nature, and used for clearing bilirubin during blood perfusion can be obtained.

Description

technical field [0001] The invention belongs to the field of bilirubin adsorbents, in particular to an aminated polyglycidyl methacrylate crosslinked composite microsphere and a preparation method thereof. Background technique [0002] Bilirubin is a product of the metabolic degradation of heme and is an endogenous toxin. Under normal physiological conditions, serum proteins combine with bilirubin to help bilirubin transfer to the liver for excretion. In patients with liver disease, due to abnormal liver function, the bilirubin metabolism pathway is blocked, and the content of unconjugated bilirubin in the blood increases. Excessively high concentrations of bilirubin, especially unconjugated bilirubin, will interfere with the normal function of cells, resulting in systemic poisoning symptoms . When the concentration of bilirubin in the blood exceeds a certain value, it will cause obstructive jaundice and even acute renal failure. [0003] The high concentration of bilirub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/14
CPCA61M1/14B01J20/26B01J20/28021
Inventor 赵长生姜鑫向韬谢毅王睿卢婷孙树东张小华
Owner SICHUAN UNIV
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