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Compound fallopia multiflora (thunb.) harald extract micro-pills and preparation method thereof

A technology of Radix Polygoni Multiflori and its extracts, which is applied in the field of pellets made of compound Radix Polygonum multiflorum extract and its preparation, to achieve the effects of rapid onset of action, large dispersion area and high bioavailability

Inactive Publication Date: 2016-04-20
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polygonum multiflorum extract and puerarin have many unilateral health products, but there is no report about the compound preparation of the two. The products are well recognized by consumers. Except for unilateral preparations, these products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; The mucous membrane is irritating to a certain extent; the disadvantages such as low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take the ingredients of the following formula for use

[0030] Polygonum multiflorum extract 15g (based on pure product)

[0031] Puerarin 1g

[0032] Vitamin cellulose 80g

[0033] Hydroxypropyl methylcellulose 4g

[0034] Prepare the pellet preparation according to the following method:

[0035] (1) Take the Polygonum multiflorum extract and puerarin of the above formula and add the crystalline cellulose, pulverize it to the micronized level with a ball mill, and mix it evenly;

[0036] (2) Dissolve hydroxypropyl methyl cellulose in 75% ethanol solution;

[0037] (3) Pellets are made by extrusion-spheronization method.

Embodiment 2

[0039] Take the ingredients of the following formula for use

[0040] Polygonum multiflorum extract 10g (based on pure product)

[0041] Puerarin 3g

[0042] Vitamin cellulose 82g

[0043] Hydroxypropyl methylcellulose 5g

[0044] Prepare the pellet preparation according to the following method:

[0045] (1) Take the Polygonum multiflorum extract and puerarin of the above formula amount into starch, pulverize it to the micronization level with a ball mill, and mix;

[0046] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0047] (3) Pellets are made by pan-pill method.

Embodiment 3

[0049] Take the ingredients of the following formula for use

[0050] Polygonum multiflorum extract 8g (based on pure product)

[0051] Puerarin 5g

[0052] Sucrose 49g

[0053] Starch 34g

[0054] Polyvinylpyrrolidone 4g

[0055] Prepare the pellet preparation according to the following method:

[0056] (1) Take the Polygonum multiflorum extract and puerarin of the above formula amount, add sucrose and starch, pulverize it to the micronized level with a ball mill, and mix well;

[0057] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0058] (3) Using centrifugal-fluidized pelletizing method to make pellets.

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Abstract

The present invention provides compound fallopia multiflora (thunb.) harald extract micro-pills, which are prepared from a fallopia multiflora (thunb.) harald extract, puerarin and pharmaceutical auxiliary materials, and are characterized in that the pharmaceutical auxiliary materials comprise an excipient and a binder, and the compound fallopia multiflora (thunb.) harald extract micro-pills comprise, by weight, 5-20% of a fallopia multiflora (thunb.) harald extract, 1-5% of puerarin, 70-85% of an excipient, and 1-5% of a binder. According to the present invention, the micro-pill preparation has characteristics of high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made from compound Polygonum multiflorum extract and a preparation method thereof. Background technique: [0002] There are many single-prescription health products of Polygonum multiflorum extract and puerarin, but there is no report about the compound preparation of the two. At present, products about Polygonum multiflorum extract and Puerarin are well received by consumers. Except for preparations, they are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which is irritating to the gastric mucosa; and low bioavailability. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/16A61K31/352
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV