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Peptidoglycan-zinc chelate for preventing and treating tumor and preparation method thereof

A technology of zinc chelate and peptidoglycan, which is applied in the field of medicine, can solve the problems of cumbersome operation, long time-consuming extraction process, and dangerous extraction reagents, and achieve the effect of increasing efficiency and improving body immunity

Inactive Publication Date: 2016-04-20
许玉灿
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  • Application Information

AI Technical Summary

Problems solved by technology

The extraction process of peptidoglycan takes a long time, the operation is cumbersome, the extraction rate is low, and the extraction reagent is dangerous

Method used

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Embodiment Construction

[0008] Preparation:

[0009] 1. Collection of strains: After expanding the culture of lactic acid bacteria (Bifidobacterium, Streptococcus thermophilus, Bulgaricus, etc.), centrifuge at 4000r / min for 30min, take the precipitation incubator at 65°C, and dry it for 2-3h. Subject to constant weight.

[0010] 2. Removal of teichoic acid: take a lactic acid bacteria sample, add preheated to 65°C, 10% TCA (trichloroacetic acid) according to the solid-to-liquid ratio of 1:5, and extract at 65°C for 1 hour. Centrifuge at 4000r / min for 30min, remove the supernatant, and wash the precipitate thoroughly with double distilled water. Distilled water and ethanol (1:2) were washed 5 times, each time for 5 minutes, and centrifuged at 4000r / min.

[0011] 3. Degreasing: Take the precipitate, add methanol according to solid-liquid (1:3), centrifuge at 4000r / min for 30min. In the same way, wash with methanol: chloroform (1:1) and chloroform once respectively, centrifuge after degreasing, and c...

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Abstract

The invention provides a peptidoglycan-zinc chelate for preventing and treating tumor and relates to the fields of medicine, food, feed adding, biochemistry and the like, in particular to the field of medicine. Single peptidoglycan is limited on the prevention and treatment effect on tumor, and the extraction process of the peptidoglycan is tedious, long in time consumption and high in dangerousness. The effect on prevention and treatment of tumor of the peptidoglycan-zinc chelate is higher than that of the peptidoglycan, especially on digestive system cancer, and extraction and synthesis processes of the peptidoglycan-zinc chelate are simpler, more convenient, more efficient and safer compared with extraction of single peptidoglycan; single zinc ions are not absorbed by the human body easily and have side effects. According to the peptidoglycan-zinc chelate and a preparation method thereof, polymer of polypeptide and sugar is used for the first time to change the form of zinc, inorganic zinc ions are converted to organozinc compounds, absorption of zinc by the human body can be more efficient, human body immunity is improved, and the effect of preventing and treating cancer of peptidoglycan can be further assisted; the peptidoglycan-zinc chelate has inhibition and prevention functions on multiple types of cancer, can improve human body immunity and further has a high-efficiency zinc-supplementation effect.

Description

1. Technical field [0001] The invention is a synthesis of a new substance, which relates to the fields of medicine, food and feed addition, biochemistry and the like, especially the field of medicine. 2. Background technology [0002] Now there is only the preparation of peptidoglycan and its method, but no one has carried out the preparation of peptidoglycan-zinc chelate. [0003] Peptidoglycan has limited inhibitory and preventive effects on tumors. The extraction process of peptidoglycan takes a long time, the operation is cumbersome, the extraction rate is low, and the extraction reagents are dangerous. [0004] Now only the use of polypeptides or organic acids to change the form of zinc, so that inorganic zinc ions into organic zinc compounds. However, the present invention uses the polymer of polypeptide and sugar to change the form of zinc for the first time, so that the efficacy can be superimposed without changing the activity of peptidoglycan. 3. Contents of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K38/16A61P35/00
CPCC08B37/00A61K38/164
Inventor 许玉灿
Owner 许玉灿
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