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A kind of vesicular microsphere with pH responsiveness and preparation method thereof

A vesicle-like and responsive technology is applied in the field of vesicle-like nano-microspheres and their preparation, which can solve the problems of no nanoparticles and reversible assembly of nano-vesicle-like microspheres, and achieve the effect of simple method and mild preparation conditions.

Active Publication Date: 2017-11-21
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the reversible assembly form can only be between monodisperse nanoparticles and random aggregates, and there is no report on the reversible assembly between nanoparticles and nanovesicle-like microspheres.

Method used

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  • A kind of vesicular microsphere with pH responsiveness and preparation method thereof
  • A kind of vesicular microsphere with pH responsiveness and preparation method thereof
  • A kind of vesicular microsphere with pH responsiveness and preparation method thereof

Examples

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Effect test

Embodiment 1

[0040] A method for preparing pH-responsive vesicular microspheres includes the following steps:

[0041] At room temperature, add 50μL of ethanol solution of 4-mercaptobenzoic acid with a concentration of 6mM to the ethanol solution of 3nm gold nanoparticles modified with oleylamine molecules. The weight of the gold nanoparticles is 0.4mg and the volume of the ethanol solution is 2mL. After the mixture was sonicated for 30 minutes, about 5 mL of petroleum ether was added and centrifuged. The obtained solid was dispersed in 2 mL of water, and then subjected to ultrasonic treatment for 30 minutes to obtain vesicle-like microspheres with pH responsiveness.

[0042] The prepared pH-responsive vesicular microspheres were characterized by transmission electron microscopy, figure 1 A is a transmission electron micrograph of vesicle-like microspheres, figure 1 B is the size distribution diagram of the vesicle-like microspheres. It can be seen that the size of the vesicle-like microsphere...

Embodiment 2

[0050] The preparation steps of pH-responsive vesicular microspheres in Example 1 were repeated, with the difference that the solid obtained after centrifugation was dispersed in the rhodamine aqueous solution. A 5mM NaOH solution was added to the obtained vesicle-like microsphere solution, and its fluorescence spectrum was measured. Rhodamine is a fluorescent molecule. When it is encapsulated by gold nanovesicles, there is almost no fluorescence in the solution. With the addition of NaOH solution, the vesicle structure is dissociated, the rhodamine molecules are released, and the fluorescence in the solution increases. Such as Figure 8A As shown, with the addition of the NaOH solution, the fluorescence in the solution gradually increased with the addition of NaOH until it no longer changed, marking the complete release of rhodamine molecules.

[0051] The dissociated gold nanoparticles are dispersed in the rhodamine aqueous solution again, and HCl is added, the gold nanoparticl...

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Abstract

The invention discloses a vesicle-shaped microsphere with pH responsiveness. The vesicle-shaped microsphere is obtained by assembling Au nanocrystals driven by ultrasound. The vesicle-shaped microsphere is of a multi-shell structure, wherein the diameter of the vesicle-shaped microsphere is 20-200 nm, and the size of the Au nanocrystals is 1-10 nm. The vesicle-shaped microsphere has high pH responsiveness and achieves reversible assembling under acid-base stimulation. The vesicle-shaped microsphere is simple, easy to obtain and capable of being applied to catalysis, medicine release and other fields.

Description

Technical field [0001] The invention relates to the preparation field of nano materials. More specifically, it relates to a vesicular nanosphere with pH responsiveness and a preparation method thereof. Background technique [0002] Among the numerous nanostructures, nanovesicle-like microspheres have potential applications in many fields due to their unique hollow structure. Nanovesicle-like microspheres composed of inorganic nanoparticles (such as Au, CuS, CdSe, etc.) have important application prospects in the fields of catalysis, drug delivery, and bioimaging due to the mutual coupling between nano-assembled unit particles. In recent years, vesicles responsive to external stimuli have continuously emerged, providing the possibility for further controllable regulation of drug delivery. So far, there have been a large number of studies on pH-responsive, thermally and light-responsive inorganic nanovesicle-like microspheres for controlled release. [0003] The Chinese invention ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04
CPCB01J13/04
Inventor 张铁锐范春芳吴骊珠佟振合
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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