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Method for preparing high-sensitivity nano-zirconia-doped pafenolol molecular imprinting electrochemical sensor

A nano-zirconia and molecular imprinting technology, applied in the direction of electrochemical variables of materials, etc., can solve the problems of inappropriate matching of functional monomers and template molecules, poor cross-linking rigidity, low sensitivity, etc., to achieve excellent sensitivity, easy production, Equipment simple effect

Inactive Publication Date: 2016-05-04
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

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  • Method for preparing high-sensitivity nano-zirconia-doped pafenolol molecular imprinting electrochemical sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of Pafevolol Molecularly Imprinted Electrochemical Sensor

[0017] To 10.0mL solvent ethanol, sequentially add 0.6mmol template molecule pafevolol, 2.0mmol functional monomer (5s, 8s)-3-(4'-chloro-3'-fluoro-4-vinyl bismuth Benzene-3-yl)-4-hydroxyl-8-ethoxy-1-azaspiro[4.5]dec-3-en-2-one, 4.5mmol crosslinking agent maleic rosin ethylene glycol acrylate, 0.2 The nanometer zirconia of mmol initiator azobisisobutyronitrile and 0.0150g is ultrasonically dissolved for 5 minutes each time a chemical reagent is added;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon el...

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Abstract

The present invention discloses a method for preparing a high-sensitivity nano-zirconia-doped pafenolol molecular imprinting electrochemical sensor, the high-sensitivity nano-zirconia-doped pafenolol molecular imprinting electrochemical sensor is prepared by use of pafenolol as a template molecule, (5s, 8s)-3-(4'-chloro-3'-fluoro-4-vinyl-biphenyl-3-yl)-4-hydroxy-8-ethyoxyl-1-aza-spiro [4.5] dec-3-ene-2-one as a single function monomer, azobisisobutyronitrile as an initiator, nano-zirconia as a dopant and maleic rosin ethylene glycol acrylate as a crosslinking agent, wherein the maleic rosin ethylene glycol acrylate is prepared from rosin as a raw material, and the method is simple and practical, and overcomes the shortcomings that a conventional analysis method is complicated, expensive in equipment, and low in sensitivity.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a high-sensitivity nanometer zirconia-doped pafilolol molecularly imprinted electrochemical sensor. Background technique [0002] Pafevolol is a highly effective drug for the treatment of heart disease. It can selectively block β1 receptors without intrinsic sympathomimetic activity. It also has blocking effects on β receptors (β2 receptors) in bronchial and vascular smooth muscle. Causes bronchospasm and constriction of nasal mucosal capillaries. Its main function is to treat heart disease and high blood pressure. However, long-term or excessive use of such drugs will cause drug addiction problems, insomnia, nausea and other side effects, and even stop the drug suddenly Therefore, it is listed as a controlled drug by most countries in the world. [0003] Methods for the determination of pafevolol include ultraviolet spectroscopy, high perf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/30G01N27/48
Inventor 谭学才韦贻春雷福厚李浩陈其锋余会成
Owner GUANGXI UNIV FOR NATITIES
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