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Intrauterine device made of degradable composite material with layered nano-structure

A technology of intrauterine contraceptives and composite materials, which is applied in the field of female contraceptive devices, can solve problems such as uncontrollable release of copper ions, dysmenorrhea in patients, complicated production, etc., achieves good contraceptive effect, eliminates severe pain, and has a simple production method Effect

Active Publication Date: 2016-05-11
LIAONING HOHO MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have also shown that the amount of human intrauterine fluid is less than 1ml. Considering the safety factor of copper-containing IUD to ensure the contraceptive effect, the minimum copper ion release rate of copper-containing IUD in intrauterine fluid must be maintained at 2.0μg / day; The copper-containing IUD contained in the copper wire or copper tube has problems such as "burst release" caused by uncontrollable copper ion release, which brings discomfort and side effects to patients such as dysmenorrhea in clinical practice, and the The procedure of IUD can also bring great pain to women
Moreover, in the existing copper-containing IUD, in order to prevent the IUD from falling off due to the rapid copper corrosion caused by the violent release of copper ions, polyethylene and other materials are usually prepared into a skeleton, and then copper wires are wound on the skeleton or copper is inlaid. set, or set the release tube of hormonal contraceptives on the bracket, which is complicated to make

Method used

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  • Intrauterine device made of degradable composite material with layered nano-structure
  • Intrauterine device made of degradable composite material with layered nano-structure
  • Intrauterine device made of degradable composite material with layered nano-structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of the degradable composite material of the layered nanostructure of the present embodiment comprises the following steps:

[0041] Step 1. Select a pure copper plate and a pure iron plate with a thickness of 4mm respectively;

[0042] Step 2. Clean the surface of the pure copper sheet and the pure iron sheet selected in step 1 by sandblasting and polishing;

[0043] Step 3, stacking the processed pure copper sheet and pure iron sheet together in step 2, and rolling at room temperature, the rolling deformation is 50% of the total thickness of the laminated sheet, to obtain a cold-rolled composite sheet;

[0044] Step 4. Put the cold-rolled composite sheet obtained in step 3 into a vacuum heat treatment furnace for annealing heat treatment. The annealing temperature is 800° C., and the annealing time is 3 hours to obtain an annealed rolled composite sheet;

[0045] Step 5, cut off the annealed rolled composite plate in step 4 from the middle, and ...

Embodiment 2

[0052] The preparation method of the degradable composite material of the layered nanostructure of the present embodiment comprises the following steps:

[0053] Step 1. Select 10 pure copper plates and 10 pure iron plates with a thickness of 0.5mm respectively;

[0054] Step 2, cleaning the surface of the pure copper sheet and the pure iron sheet selected in step 1 by pickling and polishing;

[0055] Step 3, stacking the plates processed in step 2 in a staggered combination of copper, iron, copper, and iron and rolling at room temperature, the rolling deformation is 50% of the total thickness of the stacked plates, and cold rolling is obtained. Composite panels;

[0056] Step 4. Put the cold-rolled composite sheet obtained in step 3 into a vacuum heat treatment furnace for annealing heat treatment. The annealing temperature is 800° C., and the annealing time is 3 hours to obtain an annealed rolled composite sheet;

[0057] Step 5, cut off the annealed rolled composite plate...

Embodiment 3

[0064] Such as Figure 4 As shown, the present embodiment relates to an intrauterine device with a degradable composite material having a layered nanostructure, and the IUD includes a plurality of composite material segments made of a degradable composite material having a layered nanostructure 11. Multiple composite material nodes 11 are connected in series on a non-biological suture 12, and a composite material knot 13 made of a degradable composite material with a layered nanostructure is provided at one end of the non-biological suture 12.

[0065] The IUD is composed of 6 composite material sections 11, each composite material section 11 is 5 mm long and about 2.2 mm in diameter, and is strung on a polypropylene non-biological suture 12, and then the polypropylene non-biological suture 12 The end is composed of a composite material knot 13 made of a degradable composite material with a layered nanostructure; when placed, the composite material knot 13 is fixed at 1 cm of ...

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Abstract

The invention relates to an intrauterine device made of a degradable composite material with a layered nano-structure. The intrauterine device is made of the degradable composite material with the layered nano-structure, wherein the degradable composite material is of a layered nano-structure with alternate arrangement of copper layers and iron layers, the weight percentage of copper is 40-70%, and the elasticity modulus of the composite material is 80-120 GPa. For the nano-scale layered iron / copper degradable material, the nano-scale alternate distribution of the copper layers and the iron layers is formed in the internal structure, thus the large-area direct contact between copper and the endometrium is avoided, and further, the injury to the inner conditions of the uterus caused by abundant reactive oxygen generated by excessively fast corrosion of copper is alleviated. Meanwhile, along with the degradation of iron, new copper layers are continuously exposed out, and the copper layers exposed out in the composite material are of nano-structures, so that the release of copper ions is guaranteed, and further, the contraception effect is guaranteed; good contraception effect is achieved, and meanwhile, the injury to the body is reduced.

Description

technical field [0001] The invention relates to a female contraceptive device, in particular to an intrauterine device with a degradable composite material with a layered nanostructure. Background technique [0002] The intrauterine device (Intrauterine Device IUD) is a safe, effective, economical and convenient contraceptive tool for women, and it is also one of the most widely used contraceptive methods in the world. Decades of research and clinical studies have shown that the reason why the copper-containing IUD has a very good contraceptive effect is closely related to the release of copper ions that can enhance the contraceptive effect in the uterine cavity by reacting with the intrauterine fluid. The minimum concentration of copper ions that can inhibit sperm motility in intrauterine fluid should not be less than 0.5 μg / ml, and 50% of the copper ions released by the copper-containing IUD will be absorbed by the endometrium. Studies have also shown that the amount of h...

Claims

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Application Information

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IPC IPC(8): A61F6/14
CPCA61F6/142A61F6/144
Inventor 陆剑南
Owner LIAONING HOHO MEDICAL TECH
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