Anti-angiostatin receptor monoclonal antibody conjugated nanomicelle and its preparation and application
A monoclonal antibody and nano-micelle technology, applied in the field of biomedicine, can solve the problems of side effects, inability to distinguish cancer cells from normal cells, and toxicity, and achieve the effects of small side effects, superior anti-tumor activity, and reduced side effects
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[0028] 1. Two-dimensional liquid chromatography separation technology to obtain protein HAI-178:
[0029] 2. High-efficiency and high-throughput fully human antibody technology to obtain high-expression engineering cell lines and prepare anti-HAI-178 specific humanized antibodies:
[0030] 3. Structural modification of polyoxyethylene-polyoxypropylene-polyoxyethylene block polymers:
[0031] a) Synthesis and characterization of carbonylated block polymer P123 (CT-P123);
[0032] The specific steps of polymer surface modification are: under the action of sodium hydroxide, the addition reaction of 2-butenenitrile and polyoxyethylene-polyoxypropylene-polyoxyethylene block polymer occurs, and then the addition reaction is carried out by stirring reaction The nitrile group contained in the product is hydrolyzed, and xylene is used to extract from the hydrolysis reaction product liquid to obtain a carboxyl PEO-PPO-PEO block copolymer product.
[0033] b) Linkage of CT-P123 and ant...
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