Sustained release liposome skin lotion with anti-wrinkle effect and preparation method thereof

A technology of skin care lotion and slow-release fat, which is applied in the field of cosmetics and its preparation, and can solve the problems of unsatisfactory and difficult realization of liposome transdermal absorption and slow-release effect

Inactive Publication Date: 2016-05-18
CHUANGTING COSMETIC TECH SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liposome preparation of most active ingredients is still difficult to achieve (Yu Botao, Zhang Zhirong, Liu Wensheng. Methods and research progress of improving liposome encapsulation efficiency. Chinese Journal of Pharmaceutical Industry. 2002, 33 (11): 564-568. )
[0014] 2. Liposome transdermal absorption and sustained release effect is not ideal:
However, the above membrane-penetrating peptides can only achieve targeting and cell membrane penetration by covalently linking to liposome materials.

Method used

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  • Sustained release liposome skin lotion with anti-wrinkle effect and preparation method thereof
  • Sustained release liposome skin lotion with anti-wrinkle effect and preparation method thereof
  • Sustained release liposome skin lotion with anti-wrinkle effect and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation of embodiment 1 anti-wrinkle slow-release liposome skin care liquid

[0056] Melatonin 120 parts by weight

[0057] Vitamin C380 parts by weight

[0058] 1800 parts by weight of soybean lecithin

[0059] Cholesterol 400 parts by weight

[0060] Tween-808 parts by weight

[0061] 140 parts by weight of absolute ethanol

[0062] Dowicil2008 parts by weight

[0063] 14 parts by weight of HIV-1-TAT protein 47-57 polypeptide fragment

[0064] 5000 parts by weight of deionized water

[0065] Appropriate amount of sodium bicarbonate (for adjusting the pH of the final product)

[0066] The preparation process is as follows:

[0067] 1) Take prescription amount of melatonin, Tween-80 and deionized water of prescription amount 6 / 25 to make preparation A;

[0068] 2) Take the prescribed amount of vitamin C and deionized water of 6 / 25 of the prescribed amount to make the preparation B;

[0069] 3) Take the prescription amount of soybean lecithin, cholester...

Embodiment 2

[0074] The preparation of embodiment 2 anti-wrinkle slow-release liposome skin care liquid

[0075] Melatonin 135 parts by weight

[0076] Vitamin C450 parts by weight

[0077] 1700 parts by weight of soybean lecithin

[0078] Cholesterol 500 parts by weight

[0079] Tween-8012 parts by weight

[0080] 170 parts by weight of absolute ethanol

[0081] Dowicil2009 parts by weight

[0082] 12 parts by weight of HIV-1-TAT protein 47-57 polypeptide fragment

[0083] 6000 parts by weight of deionized water

[0084] Appropriate amount of sodium bicarbonate (for adjusting the pH of the final product)

[0085] The preparation process is as follows:

[0086] 1) Take prescription amount of melatonin, Tween-80 and deionized water of prescription amount 6 / 25 to make preparation A;

[0087] 2) Take the prescribed amount of vitamin C and deionized water of 7 / 25 of the prescribed amount to make the preparation B;

[0088] 3) Take the prescription amount of soybean lecithin, choleste...

Embodiment 3

[0093] The preparation of embodiment 3 anti-wrinkle slow-release liposome skin care liquid

[0094] Melatonin 115 parts by weight

[0095] Vitamin C320 parts by weight

[0096] 2000 parts by weight of soybean lecithin

[0097] Cholesterol 320 parts by weight

[0098] Tween-8014 parts by weight

[0099] 190 parts by weight of absolute ethanol

[0100] Dowicil2006 parts by weight

[0101] HIV-1-TAT protein 47-57 polypeptide fragment 9 parts by weight

[0102] 7500 parts by weight of deionized water

[0103] Appropriate amount of sodium bicarbonate (for adjusting the pH of the final product)

[0104] The preparation process is as follows:

[0105] 1) Take the prescribed amount of melatonin, Tween-80 and deionized water of 5 / 25 of the prescribed amount to make the formulation A;

[0106] 2) Take the prescribed amount of vitamin C and deionized water of 7 / 25 of the prescribed amount to make the preparation B;

[0107] 3) Take the prescription amount of soybean lecithin, c...

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Abstract

The invention relates to the technical field of cosmetics and preparation thereof, in particular to sustained release liposome skin lotion with an anti-wrinkle effect and a preparation method thereof. The skin lotion is prepared from, by weight, a pH regulator, 100-140 parts of melatonin, 300-460 parts of vitamin C, 1,500-2,400 parts of soya bean lecithin, 300-600 parts of cholesterol, 5-15 parts of tween-80, 100-200 parts of absolute ethyl alcohol, 5-10 parts of Dowicil 200, 5-15 parts of HIV-1-TAT protein 47-57 polypeptide fragments and 3,000-8,000 parts of deionized water by adopting an ultrasonic method. The sustained release liposome skin lotion has the advantages of being small in particle size, high in uniformity and encapsulation ratio and long in sustained releasing time.

Description

technical field [0001] The invention belongs to the technical field of cosmetics and its preparation, and in particular relates to a slow-release liposome skin care liquid with anti-wrinkle effect and a preparation method thereof. Background technique [0002] Skin aging is a phenomenon of skin aging caused by natural or unnatural factors. Wrinkles are one of the signs of aging skin. Usually long-term exposure to light, mental stress, drug stimulation, oxidative damage, skin moisture loss, etc. can lead to the generation or increase of wrinkles. [0003] Melatonin and vitamin C are currently commonly used anti-wrinkle active substances. Chinese patent document CN1131021C (application number 00125700.5, date of application October 17, 2000) discloses an anti-wrinkle cosmetic, one of its active ingredients is melatonin. [0004] At present, the anti-wrinkle cosmetics commonly used at home and abroad are mostly ordinary creams or emulsions. Due to the existence of the skin b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/67A61K8/64A61K8/49A61K8/55A61Q19/08
CPCA61K8/14A61K8/492A61K8/553A61K8/64A61K8/676A61K2800/592A61K2800/82A61Q19/08
Inventor 江俊达
Owner CHUANGTING COSMETIC TECH SHANGHAI
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