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Composition for preventing and treating pediatric skin diseases and preparation method of composition

A composition and preparation technology, applied in the field of composition, can solve the problems of inapplicability for infants and young children, and achieve the effect of easy acceptance, no drug resistance, and less allergy

Inactive Publication Date: 2016-05-18
YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs for treating diaper dermatitis (red buttocks) and dermatitis, but most of them are western medicine formulas, mainly for adults, not suitable for infants

Method used

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  • Composition for preventing and treating pediatric skin diseases and preparation method of composition
  • Composition for preventing and treating pediatric skin diseases and preparation method of composition
  • Composition for preventing and treating pediatric skin diseases and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take 30-70 parts by weight of comfrey and 5-20 parts of borneol, grind the comfrey into powder, and grind the borneol into powder. Add Coptidis 30-70 and Rhubarb 30-70 in parts by weight, add ethanol with a concentration of 50v / v%-95v / v% and decoct three times, filter the decoction, combine, and concentrate to a relative density of 1.15-1.25 (60°C ~65℃), put 1w / w%~2w / w% triethanolamine, 5w / w%~20w / w% glycerin, 0.1w / w% ethyl paraben, and the balance is water to the container Mix in water to obtain the water phase, heat to 80°C and keep it warm; take another mixture of 10w / w%~16w / w% stearic acid, 10w / w%~20w / w% vaseline and paraffin or liquid paraffin and 1w / w% ~5w / w% lanolin is put into another container and heated and melted to obtain an oil phase. The total amount of the oil phase and the water phase is 100w / w when kept at 80°C, and the balance is made up with water. Add the oil phase to the water phase in a thin stream, stir in the same direction, cool to 45°C-50°C, ad...

Embodiment approach

[0052] The Chinese medicine composition ointment that present embodiment 1 makes (named: Erxujing ointment) carries out pre-clinical experiment, and the implementation scheme is as follows:

[0053] (1) Clinical data

[0054] 1. Source of cases: The sources of all research medical records are children from the Pediatric Outpatient Department of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine.

[0055] 2. Case selection criteria: (1) mainly infants and young children aged 0-3; (2) eczema mainly occurs on the forehead, eyebrows, cheeks, scalp, around the auricles, shoulders, back, and limbs ; Diaper dermatitis (red buttocks) is mainly on the buttocks, perineum, hepatic hilum, and thigh root; Distending pain, exudate and erosion, local itching and tenderness; (4) accompanied by symptoms such as crying, irritability, and poor sleep, and severe cases accompanied by systemic symptoms such as fever and skin ulcers.

[0056] 3. Inclusion criteri...

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Abstract

The invention relates to a composition for preventing and treating pediatric skin diseases. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 30-70 parts of radix lithospermi, 30-70 parts of rhizoma coptidis, 30-70 parts of radix et rhizoma rhei, and 5-20 parts of borneol. According to the composition, radix lithospermi is taken as the monarch drug, and is matched with the other traditional Chinese medicinal materials to prepare the composition, the composition aims at the tender skin of children, has the efficacies of clearing away heat and toxic materials, as well as removing dampness and relieving itching, and is mild without irritation, irritability is seldom caused, no drug resistance is generated, and the composition is easy to accept by children patients and parents.

Description

technical field [0001] The invention relates to a composition prepared by processing plants, in particular to a composition of Chinese medicinal materials with comfrey as the main drug, which is used for the prevention and treatment of children's skin diseases. Background technique [0002] Infant eczema, commonly known as ringworm of milk, is a skin inflammatory reaction with obvious exudation tendency caused by various factors. It occurs in infants aged 1 to 6 months. bring a lot of trouble. In recent years, the incidence of eczema in infants and young children has an upward trend, and it is lingering and recurrent. Currently, eczema medicines on the market are divided into two types: traditional Chinese medicine and western medicine. Western medicine mostly uses oral antihistamines and topical steroid ointment for treatment. Although it is effective, it has large side effects, many adverse reactions, and easy to relapse after stopping the medicine. It is not suitable for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K36/30A61K36/75A61K36/744A61P17/00A61P17/02
Inventor 郑璐吴斌范明松
Owner YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
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