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Acarbose-containing pharmaceutical composition for treating diabetes and preparation method thereof

The technology of acarbose and its composition is applied in the field of pharmaceutical compositions for treating diabetes and its preparation, which can solve the problems such as restricting the use of acarbose, and achieve the effects of avoiding adverse reactions, improving therapeutic effects and having less side effects.

Inactive Publication Date: 2016-05-25
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common adverse reactions of acarbose are gastrointestinal reactions, common diarrhea, abdominal distension, abdominal pain, nausea, vomiting, the incidence rate is as high as 30%, this adverse reaction limits the use of acarbose

Method used

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  • Acarbose-containing pharmaceutical composition for treating diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0039] Acarbose 50g, dwarf bayberry fruit 3000g, nosebleed thunder 3000g, chaotic tree 3000g, bluegrass 3000g.

[0040]The preparation method of the pharmaceutical composition for treating diabetes:

[0041] a. Add water to decoct dwarf red bayberry fruit, nosebleed thunder, chaotic tree, and bluegrass for 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add 5 times the volume of medicine for the second time, decoct Boil for 1 hour, combine the decoction and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing the acarbose with th...

Embodiment 2

[0047] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0048] Acarbose 40g, dwarf bayberry fruit 3500g, nosebleed thunder 2500g, chaotic tree 3500g, bluegrass 2500g.

[0049] The preparation method of the pharmaceutical composition for treating diabetes:

[0050] a. Add water to decoct dwarf bayberry fruit, nosebleed thunder, chanting tree, and bluegrass for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add 6 times the volume of medicine for the second time, decoct Cook for 1.5 hours, combine the decoction liquid, and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing the acarbose ...

Embodiment 3

[0056] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0057] Acarbose 60g, dwarf bayberry fruit 2500g, nosebleed thunder 3500g, chaotic tree 2500g, bluegrass 3500g.

[0058] The preparation method of the pharmaceutical composition for treating diabetes:

[0059] a. Add water to decoct dwarf red bayberry fruit, nosebleed thunder, chaotic tree, and bluegrass for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, decoct Boil for 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing the acarb...

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Abstract

The invention belongs to the technical field of medicine and particularly relates to an acarbose-containing pharmaceutical composition for treating diabetes and a preparation method thereof. The acarbose-containing pharmaceutical composition for treating diabetes is prepared from the following raw medicines in parts by weight: 30-70 parts of acarbose, 2000-4000 parts of short waxberries, 2000-4000 parts of tubeflower dutchmanspipe root, 2000-4000 parts of litsea glutinosa and 2000-4000 parts of meadow grass. The acarbose-containing pharmaceutical composition combines traditional Chinese medicines and acarbose, so that common adverse reactions of acarbose can be avoided, and the curative effect on diabetes can be increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing acarbose for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiologies. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormones that antagonize insulin, or the inability of insuli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P3/10A61K31/7036
CPCA61K31/7036A61K9/1652A61K36/185A61K36/264A61K36/54A61K36/899A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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