Sodium alginate-agar dual-network high-strength natural hydrogel material, and preparation method thereof

A sodium alginate and gel material technology, applied in the field of polymer materials, can solve the problems of chemical cross-linking that cannot be rebuilt, and achieve great application value, easy operation, and good biocompatibility

Inactive Publication Date: 2016-05-25
HUBEI UNIV OF TECH
View PDF2 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above double-network hydrogels all use chemical monomers and chemical

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sodium alginate-agar dual-network high-strength natural hydrogel material, and preparation method thereof
  • Sodium alginate-agar dual-network high-strength natural hydrogel material, and preparation method thereof
  • Sodium alginate-agar dual-network high-strength natural hydrogel material, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] Example 1

[0038] 1) Add 0.88g of sodium alginate (SA) powder into 30mL of deionized water, stir in a 65°C water bath for 30 minutes to fully dissolve it, and obtain a sodium alginate (SA) solution with a mass fraction of 2.85%; 4.4g of agar ( Agar) powder was added into 80mL of deionized water, stirred in a 95°C water bath for 30 minutes to fully dissolve it in deionized water to obtain an agar (Agar) solution with a mass fraction of 5.21%;

[0039] 2) Add the agar (Agar) solution in step 1) into the sodium alginate (SA) solution, and stir in a water bath at 65° C. for 15 minutes to obtain a mixed solution;

[0040] The mass fraction of agar (Agar) in the mixed solution is 3.82%, and the mass ratio of sodium alginate (SA) to agar (Agar) in the mixed solution is 1.0:5.0;

[0041] 3) Use a disposable syringe to extract 5 mL of the mixed solution in step 2), and centrifuge to remove air bubbles to obtain a transparent and uniform mixed solution;

[0042] 4) Cool the mi...

Example Embodiment

[0045] Embodiment 2, with embodiment 1, difference is,

[0046] 1) Add 5.80 g of agar (Agar) powder into 80 mL of deionized water, stir in a water bath at 95° C. for 30 minutes, fully dissolve it in deionized water, and obtain an agar (Agar) solution with a mass fraction of 6.76%;

[0047] 2) Add the agar (Agar) solution in step 1) into the sodium alginate (SA) solution, and stir in a water bath at 65° C. for 15 minutes to obtain a mixed solution;

[0048] The mass fraction of agar (Agar) in the mixed solution is 4.97%, and the mass ratio of sodium alginate (SA) to agar (Agar) in the mixed solution is 1.0:6.6;

[0049] 5) Cut the disposable syringe, take out the preformed gel from the syringe tube, and dissolve the preformed gel in 30mL0.75mol / LCaCl 2 Soaked in aqueous solution for 5 hours, Ca 2+ Sodium alginate (SA) is cross-linked into the second network by diffusing into the preformed hydrogel, and sodium alginate agar fully physically cross-linked high-strength double-ne...

Example Embodiment

[0051] Embodiment 3, with embodiment 1, difference is,

[0052] 1) Add 8.80 g of agar (Agar) powder into 80 mL of deionized water, stir in a water bath at 95°C for 30 minutes to fully dissolve it in deionized water, and obtain an agar (Agar) solution with a mass fraction of 9.91%;

[0053] 2) Add the agar (Agar) solution in step 1) into the sodium alginate (SA) solution, and stir in a water bath at 65° C. for 15 minutes to obtain a mixed solution;

[0054] The mass fraction of agar (Agar) in the mixed solution is 7.35%, and the mass ratio of sodium alginate (SA) to agar (Agar) in the mixed solution is 1.0:10.0;

[0055] 5) Cut the disposable syringe, take out the preformed gel from the syringe tube, and dissolve the preformed gel in 30mL0.5mol / LCaCl 2 Soaked in aqueous solution for 6 hours, Ca 2+ Sodium alginate (SA) is cross-linked into the second network by diffusing into the preformed hydrogel, and sodium alginate agar fully physically cross-linked high-strength double-ne...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Tensile breaking strengthaaaaaaaaaa
Tensile breaking strengthaaaaaaaaaa
Tensile breaking strengthaaaaaaaaaa
Login to view more

Abstract

The invention relates to a preparation method of a sodium alginate-agar dual-network high-strength natural hydrogel material. The preparation method comprises following steps: a sodium alginate solution is prepared at 65 DEG C, an agar solution is prepared under 95 DEG C, and the agar solution is added into the sodium alginate solution so as to obtain a mixed solution; the mixed solution is cooled to room temperature, wherein in the cooling process, a first network is formed via hydrogen bonding crosslinking of agar molecular chains, and the mixed solution is changed into preformed hydrogel; and the preformed hydrogel is immersed into a CaCl2 aqueous solution for 4 to 6h, wherein a second network is formed via crosslinking of sodium alginate via diffusion of Ca2+ into the preformed hydrogel, and the sodium alginate-agar full physically crosslinked high-strength dual-network natural hydrogel is obtained. According to the preparation method, degradable natural plant extracts with excellent biocompatibility are taken as the raw materials to prepare the sodium alginate-agar dual-network high-strength natural hydrogel material; operation is convenient; product strength is high; and the sodium alginate-agar dual-network high-strength natural hydrogel material possesses biodegradability, and can be taken as a biological soft tissue substitute.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a preparation method of a sodium alginate agar double-network high-strength natural hydrogel material. Background technique [0002] As a soft material composed of a three-dimensional cross-linked network of hydrophilic polymers with a water content as high as 50-90%, hydrogel has similar properties to biological soft tissues and has broad application prospects in the field of biological soft tissue substitute materials. In particular, double network hydrogel, a soft material with high strength, high water content and low friction properties, is an excellent cartilage tissue replacement material. In recent years, remarkable progress has been made in the preparation of high-strength double-network hydrogels: PEGMA / PAA double-network hydrogels (SinaNaficy, JoselitoM.Razal, PhilipG.Whitten, GordonG.Wallace, GeoffreyM.Spinks.PolymerPhysics , 2012,50,423-430), S...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08J3/075C08J3/24C08L5/04C08L5/12
Inventor 李学锋杨倩龙世军袁亚赵友姣陈明敏徐恒
Owner HUBEI UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products