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Preparation method of antibacterial polysaccharide hemostatic cotton based gauze

A hemostatic cotton, antibacterial technology, applied in the field of preparation of antibacterial polysaccharide hemostatic cotton-based gauze, can solve the problems of limited antibacterial ability, low mechanical strength, single function, etc.

Active Publication Date: 2016-06-08
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These hemostatic materials have different hemostatic effects, but they are single-function and expensive
[0003] In the Chinese patent CN202604936U, a gelatin sponge hemostatic cotton was prepared; in the Chinese patent CN102908651A, an oxidized cellulose hemostatic material was prepared; these hemostatic cottons have a good hemostatic effect, but their functions are relatively single, and they do not have antibacterial and anti-inflammatory properties. effect
In Chinese patent CN101816802A, a chitosan-based medical dressing is prepared. This hemostatic cotton has antibacterial effect, but its antibacterial ability is limited and its mechanical strength is low.

Method used

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  • Preparation method of antibacterial polysaccharide hemostatic cotton based gauze
  • Preparation method of antibacterial polysaccharide hemostatic cotton based gauze
  • Preparation method of antibacterial polysaccharide hemostatic cotton based gauze

Examples

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Effect test

Embodiment 1

[0024] 1) Preparation of quaternized polyethyleneimine with antibacterial function: 3 g of polyethyleneimine was dissolved in 10 mL of tetrahydrofuran; a mixed solution of 5 mL of hexane bromide and 5 mL of tetrahydrofuran was added to the solution of polyethyleneimine in tetrahydrofuran, 50 ° C Reaction for 12 hours; after the reaction, tetrahydrofuran was removed by rotary evaporation, and dried under reduced pressure to obtain quaternized polyethyleneimine;

[0025] 2) Dissolve 5g of hyaluronic acid with a molecular weight of 1.2 million in 100mL of deionized water, dissolve 1g of sodium periodate in 50mL of deionized water; add the sodium periodate solution to the hyaluronic acid solution, react for 10 hours and use The dialysis bag with a molecular weight cut-off of 3500 was dialyzed for 24 hours, and finally freeze-dried to obtain the formaldehyde hyaluronic acid cross-linking agent;

[0026] 3) Weigh 2g of chitosan hydrochloride and dissolve it in 50mL of water, stir to...

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Abstract

The invention discloses a preparation method of an antibacterial polysaccharide hemostatic cotton based gauze. The method comprises the following steps: firstly, preparing a quaternized polyethyleneimine and a hydroformylation polysaccharide cross-linking agent which have an anti-bacterial function; and then mixing and foaming the quaternized polyethyleneimine, the hydroformylation polysaccharide cross-linking agent and chitosan hydrochloride, uniformly coating the surface of a preprocessed gauze with foaming liquid, and carrying out freeze drying to obtain the antibacterial polysaccharide hemostatic cotton based gauze. After being compounded, polysaccharide hemostatic cotton and the preprocessed gauze are combined closely, do not fall off, have high intensity, and are suitable for compression hemostasis and binding at wounds. Moreover, compared with a common gauze, the antibacterial polysaccharide hemostatic cotton based gauze has the effects of inhibiting growth of microorganisms and inhibiting bacteria when stopping bleeding. In addition, a sponge coating the surface of the gauze uses safe and nontoxic polysaccharide as the cross-linking agent, so that the intensity and the blood stopping effect of the hemostatic cotton based gauze are further improved.

Description

technical field [0001] The invention relates to a preparation method of antibacterial polysaccharide hemostatic cotton-based gauze, which belongs to the field of biomedical materials. Background technique [0002] At present, various new medical biological hemostatic materials are constantly emerging. Commonly used clinical biological hemostatic materials include oxidized cellulose, gelatin sponge, chitosan and calcium alginate fiber. These hemostatic materials all have different hemostatic effects, but have a single function and are expensive. [0003] In the Chinese patent CN202604936U, a gelatin sponge hemostatic cotton was prepared; in the Chinese patent CN102908651A, an oxidized cellulose hemostatic material was prepared; these hemostatic cottons have a good hemostatic effect, but their functions are relatively single, and they do not have antibacterial and anti-inflammatory properties. effect. In Chinese patent CN101816802A, a chitosan-based medical dressing is prep...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/42
CPCA61L15/26A61L15/28A61L15/42A61L15/425A61L15/44A61L2300/208A61L2300/404A61L2400/04C08L79/02C08L5/08
Inventor 徐福建胡浩
Owner BEIJING UNIV OF CHEM TECH
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