Preparation method of antibacterial polysaccharide hemostatic cotton based gauze
A hemostatic cotton, antibacterial technology, applied in the field of preparation of antibacterial polysaccharide hemostatic cotton-based gauze, can solve the problems of limited antibacterial ability, low mechanical strength, single function, etc.
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[0024] 1) Preparation of quaternized polyethyleneimine with antibacterial function: 3 g of polyethyleneimine was dissolved in 10 mL of tetrahydrofuran; a mixed solution of 5 mL of hexane bromide and 5 mL of tetrahydrofuran was added to the solution of polyethyleneimine in tetrahydrofuran, 50 ° C Reaction for 12 hours; after the reaction, tetrahydrofuran was removed by rotary evaporation, and dried under reduced pressure to obtain quaternized polyethyleneimine;
[0025] 2) Dissolve 5g of hyaluronic acid with a molecular weight of 1.2 million in 100mL of deionized water, dissolve 1g of sodium periodate in 50mL of deionized water; add the sodium periodate solution to the hyaluronic acid solution, react for 10 hours and use The dialysis bag with a molecular weight cut-off of 3500 was dialyzed for 24 hours, and finally freeze-dried to obtain the formaldehyde hyaluronic acid cross-linking agent;
[0026] 3) Weigh 2g of chitosan hydrochloride and dissolve it in 50mL of water, stir to...
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