Application of clostridium butyricum in preparation of medicines for treating and/or preventing acute liver injury
A technology for acute liver injury and butyric acid bacteria, applied in the field of medicine, can solve problems such as butyric acid bacteria that have not yet been found, and achieve the effects of effectively treating liver injury, restoring normal liver function, and reducing oxidative stress.
Inactive Publication Date: 2016-06-22
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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However, so far, no information about the application of b
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Embodiment 1
[0050] Butyric acid bacteria culture
[0051] The butyric acid bacteria parent strain was anaerobically cultured in TPY liquid medium, and the butyric acid bacteria in the logarithmic growth period were administered to the mice of the butyric acid bacteria pretreatment group.
[0052] ALI modeling and animal grouping
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The invention discloses application of clostridium butyricum in preparation of medicines for treating and/or preventing acute liver injury, belonging to the field of medicines. According to the application, the clostridium butyricum is capable of relieving oxidative stress response in the acute liver injury by improving the activity of superoxide dismutase and catalase as well as reducing the content of malonaldehyde in the liver tissue, and can reduce the accumulation of IL-1beta, IL-6 and TNF-alpha in the liver tissue at the same time; therefore, the clostridium butyricum has functions of resisting oxidative stress and resisting inflammatory response, and is capable of effectively treating liver injury so as to restore the normal liver functions. Furthermore, the main metabolite of the clostridium butyricum is butyric acid, so that the clostridium butyricum is beneficial to the protection of the liver.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the application of a butyric acid bacterium in the preparation of medicines for treating and / or preventing acute liver injury. Background technique [0002] Acute liver injury (ALI) refers to abnormal liver function caused by various etiologies without chronic liver disease. It is the basis of acute liver failure. Severe or persistent liver injury will eventually lead to liver failure. Functional failure poses a great safety hazard to patients. Therefore, it is very necessary to provide a medicine for treating acute liver injury. [0003] Studies have shown that the causes of acute liver injury are mainly viral infection, improper use of drugs, excessive alcohol intake, ingestion of toxic food, radiation injury, systemic infection, etc., and these causes cause oxidative stress and inflammation in patients , based on this, the existing technology is mostly focused on the development of s...
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CPCA61K35/742
Inventor 褚茂平王方岩刘佳明付瑶阳张浩王雅棋陈筱筱
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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