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Traditional Chinese medicine compound perfusion agent for treating cow mastitis and preparation method thereof

A cow mastitis and perfusion agent technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of inconvenient operation and unsatisfactory treatment effect, so as to avoid the loss of discarded milk and have a definite curative effect , high bioavailability

Inactive Publication Date: 2016-06-22
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment effect of local method of applying traditional Chinese medicine on the breast of cows is not satisfactory, and the operation is not convenient

Method used

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  • Traditional Chinese medicine compound perfusion agent for treating cow mastitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Accurately weigh 6g of Scutellaria baicalensis, 12g of forsythia, 20g of holly, 6g of bitter wood, 6g of golden fruit olive, 10g of leaking reed, 20g of Senecio, 20g of Hedyotis diffusa, 8g of Piper longum, 30g of Scutellaria barbata, 800.5 polysorbate g, sodium bisulfite 2g, sodium chloride 0.9g; decoct Scutellaria baicalensis with 8 times the amount of water twice, the first time for 2 hours, the second time for 1 hour, add hydrochloric acid to adjust the pH to 1.0-2.0, and keep warm at 70°C 1h, let it stand overnight, filter, disperse the precipitate evenly with 8 times the amount of water, adjust the pH to 7.0 with 20% sodium hydroxide solution, add an equal amount of ethanol and stir to dissolve, filter, and adjust the pH of the filtrate to 1.0-2.0 with hydrochloric acid , keep warm at 60°C for 1h, cool to room temperature, let stand for 12h, filter, wash the precipitate with corresponding concentration of ethanol until the pH reaches 7.0, add 0.3% activated carbon ...

Embodiment 2

[0033]Accurately weigh 13g of Scutellaria baicalensis, 21g of forsythia, 40g of holly, 7.5g of bitter wood, 12g of golden fruit olive, 14g of leaking reed, 30g of Senecio, 30g of Hedyotis diffusa, 16g of Piper longum, 45g of Scutellaria barbata, polysorbate 802g, 2g sodium bisulfite, 0.9g sodium chloride; decoct Scutellaria baicalensis with 8 times the amount of water twice, the first time for 2 hours, the second time for 1 hour, add hydrochloric acid to adjust the pH to 1.0-2.0, and keep warm at 70°C 1h, let it stand overnight, filter, disperse the precipitate evenly with 8 times the amount of water, adjust the pH to 7.0 with 20% sodium hydroxide solution, add an equal amount of ethanol and stir to dissolve, filter, and adjust the pH of the filtrate to 1.0-2.0 with hydrochloric acid , keep warm at 60°C for 1h, cool to room temperature, let stand for 12h, filter, wash the precipitate with corresponding concentration of ethanol until the pH reaches 7.0, add 0.3% activated carbon...

Embodiment 3

[0035] Accurately weigh 20g of Scutellaria baicalensis, 30g of forsythia, 60g of holly, 9g of bitter wood, 18g of golden fruit olive, 18g of leaking reed, 40g of Senecio, 40g of hedyotis diffusa, 24g of longan, 60g of Scutellaria barbata, 803g of polysorbate , sodium bisulfite 2g, sodium chloride 0.9g; decoct Scutellaria baicalensis with 8 times the amount of water twice, the first time for 2 hours, the second time for 1 hour, add hydrochloric acid to adjust the pH to 1.0-2.0, and keep it warm at 70°C for 1 hour , stand overnight, filter, the precipitate is dispersed evenly with 8 times the amount of water, adjust the pH to 7.0 with 20% sodium hydroxide solution, add an equal amount of ethanol and stir to dissolve, filter, and adjust the pH of the filtrate to 1.0-2.0 with hydrochloric acid, Incubate at 60°C for 1h, cool to room temperature, let stand for 12h, filter, wash the precipitate with ethanol of the corresponding concentration until the pH reaches 7.0, add 0.3% activate...

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Abstract

The invention provides a traditional Chinese medicine compound perfusion agent for treating cow mastitis and a preparation method thereof, and belongs to veterinary sterilizing liquid preparation technologies. The traditional Chinese medicine compound perfusion agent is prepared from, by weight, baical skullcap roots, fructus forsythiae, pubescent holly roots, ramulus et folium picrasmae, arrowshaped tinospora roots, uniflower swisscentaury roots, climbing groundsel herb, spreading hedyotis herb, fructus piperis longi, barbed skullcap herb, polysorbate 80, sodium bisulfite, sodium chloride and water for injection. The preparation method of the traditional Chinese medicine compound perfusion agent comprises the steps that an extracting solution obtained by extracting fructus forsythiae, pubescent holly roots, uniflower swisscentaury roots, spreading hedyotis herb, arrowshaped tinospora roots and barbed skullcap herb and an extracting solution obtained by extracting ramulus et folium picrasmae, climbing groundsel herb and fructus piperis longi are merged and stirred, an extract obtained by extracting baical skullcap roots is added, stirring is conducted, polysorbate 80, sodium bisulfite and sodium chloride are added, stirring is conducted till complete dissolution is achieved, the water for injection is added till the whole volume is 100 ml, stirring is conducted, standing is conducted for 12 h at 4 DEG C, filtering is conducted through a micropore filtration membrane of 0.45 micrometers, subpackaging and capping are conducted, moist heat sterilization is conducted for 20 min at 121 DEG C, and the traditional Chinese medicine compound perfusion agent is obtained. The traditional Chinese medicine compound liquid sterilizing preparation directly acts on lesions and is high in bioavailability, high in targeted property and good in curative effect.

Description

technical field [0001] The invention belongs to veterinary sterilized liquid preparation and preparation technology, and mainly relates to a traditional Chinese medicine compound perfusion agent for treating cow mastitis and a preparation method thereof. Background technique [0002] Cow mastitis is one of the most common diseases of dairy cows and one of the main factors causing economic losses in the dairy industry. The treatment of mastitis in dairy cows currently adopts oral administration, external application on the udder wall, intramuscular injection, intravenous injection, milk pool perfusion and other administration methods, and the main ingredients are traditional Chinese medicine, antibiotics or chemicals. Common treatment methods include antibiotic therapy and traditional Chinese medicine therapy. Such as: antibiotics penicillin, streptomycin, ampicillin, ceftiofur sodium, etc., chemicals such as enrofloxacin, ciprofloxacin lactate, sulfonamide, etc. Although th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61P15/14
CPCA61K9/0041A61K9/08A61K36/185A61K36/28A61K36/539A61K36/59A61K36/634A61K36/67A61K36/748A61K47/02A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 岳奎忠武浩楠白玉刚刘莉李俊张翔岳宇恒徐志辉
Owner NORTHEAST AGRICULTURAL UNIVERSITY