The invention relates to a medicine for treating the diabetic foot disease and a preparing method thereof. The medicine comprises, by weight, 30-60 of anredera cordifolia, 15-30 of garden balsam stems, 6-12 of angelica sinensis, 3-10 of liguticum wallichii, 6-12 of roots of common peony, 1-3 of dragon's blood, 9-15 of sargentgloryvine stems, 5-12 of the root of bidentate achyranthes, 3-12 of rheum officinale, 7-15 of golden cypress, 6-15 of rhizome bletillae, 1-5 of radix agelicae, 3-5 of borneol, and 0.5-1 of ketoconazole. The medicine has the effects of clearing heat and toxic materials, promoting blood circulation to remove blood stasis, removing thee necrotic tissue and promoting granulation, stopping bleeding by astringency, and stopping pain, is antimicrobial, anti-infection, anti-inflammatory, antibiosis, antioxidant, anti-aging, anticancer, antifungal, and fungal injection preventing, improves microcirculation, and promotes skin metabolism. The medicine mainly treats the diabetic foot disease, deep-rooted boil, ulcers and sores, swelling of ulcerated muscle, skin crowfoot cracks, furuncle boils, and the like.