5-fluorocytosine fluorination reactor with stirring function

Abstract

The invention discloses a 5-fluorocytosine fluorination reactor with the stirring function. The outer surface of a barrel (1) is sleeved with a cooling jacket (2); the middle of the upper portion of the barrel (1) is provided with a solid material adding device (12); one side of the upper portion of the barrel (1) is provided with a gaseous phase outlet (10) which is internally provided with an electric discharging valve (8); the other side of the upper portion of the barrel (1) is provided with a temperature measuring sleeve (7); the upper portion of the temperature measuring sleeve (7) is located outside the barrel (1); the lower portion of the temperature measuring sleeve (7) is located in the barrel (1); the upper portion of the side face of the barrel (1) is provided with a fluorine and nitrogen inlet pipe (4) which is communicated with the interior of the barrel (1); a gas distributor (5) is arranged at the bottom of the barrel (1); a cooling coil pipe (3) is arranged on the inner surface of the barrel (1); a stirrer (6) is arranged at the center of the barrel (1); a liquid level meter port (9) is formed in the side face of the lower portion of the barrel (1); a liquid phase discharge port (11) is formed in the bottom of the barrel (1).

Description

technical field [0001] The invention relates to a stirred 5-fluorocytosine fluorination reactor. Background technique [0002] The current production of 5-fluorocytosine dissolves cytosine in anhydrous HF, and passes a fluorine-nitrogen mixture with a fluorine content of about 20% to generate 5-fluorocytosine. As an important equipment, the fluorination reactor is related to safety, environmental protection, product quality and consumption. For a long time, it has been difficult to control the temperature of the fluorination reactor (reaction at low temperature, another substance is generated at high temperature, or even overheating occurs, cytosine is carbonized, the reaction pressure rises, and there is a safety hazard, so the temperature control is very strict.), the mixer seal Leakage of fluorine gas and cytosine feed rate is difficult to control, which restricts the development of a process route for the production of 5-fluorocytosine using fluorine gas and cytosine as...

AI Technical Summary

Problems solved by technology

For a long time, it has been difficult to control the temperature of the fluorination reactor (reaction at low temperature, another substance is generated at high temperature, and even overheating occurs, cytosine is carbonized, the reaction pressure rises, and there are potential safety hazards, so the temperature control is very strict

), the feed rate of fluorine gas and cytosine leaked from the mixer seal is difficult to control, which restricts the development of a process route for the production of 5-fluorocytosine using fluorine gas and cytosine as raw materials

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