Detection method for limit of sulfite
A technology of sulfite and detection method, which is applied in the preparation of test samples, material analysis by observing the influence on chemical indicators, and analysis by chemical reaction of materials, etc., to achieve low cost of reagents and equipment, reagents And the cost of equipment is safe, non-toxic, non-polluting, and easy to operate.
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Embodiment 1
[0142] The inspection method of sulfite limit in embodiment 1 ofloxacin crude drug:
[0143] (1) Accurately weigh 196.9 mg of anhydrous sodium sulfite (equivalent to 100 mg of SO 2 ), put it in a 100ml measuring bottle, add purified water to dissolve and dilute to the scale, and shake up; accurately measure 1ml, put it in a 10ml measuring bottle, add purified water to dilute to the mark, shake up, and use it as a standard sodium sulfite solution (containing SO 2 The concentration is 100 μg / ml).
[0144] (2) Accurately weigh 1.0 g ofloxacin bulk drug, add 30 ml of water, shake fully to obtain a yellow transparent solution, put the filtrate in a 50 ml Nessler colorimetric tube, add 2 ml of dilute hydrochloric acid of 10% mass fraction, add 30 % hydrogen peroxide 2ml, shake well, that is the test solution. Prepare another test solution in the same way.
[0145] (3) Take a portion of the test solution, add 2ml of 30% hydrogen peroxide, add 5ml of 25% barium chloride solution, l...
Embodiment 2
[0148] Embodiment 2 The inspection method of the sulfite limit in the ezetimibe bulk drug comprises the following steps:
[0149] (1) Accurately weigh 196.9 mg of anhydrous sodium sulfite (equivalent to 100 mg of SO 2 ), put it in a 100ml measuring bottle, add purified water to dissolve and dilute to the scale, and shake up; accurately measure 1ml, put it in a 10ml measuring bottle, add purified water to dilute to the mark, shake up, and use it as a standard sodium sulfite solution (containing SO 2 The concentration is 100 μg / ml).
[0150] (2) Accurately weigh 1.0 g of ezetimibe crude drug, add appropriate amount of water, shake fully, filter, put the filtrate in a 50 ml Nessler colorimetric tube, add water to 40 ml, add 2 ml of dilute hydrochloric acid, add 3 ml of 20% hydrogen peroxide, Shake well to obtain the test solution.
[0151] (3) Take 1ml of standard sodium sulfite solution, put it in a 50ml Nessler colorimetric tube, add water to make about 40ml, add 2ml of dilut...
Embodiment 3
[0153] The inspection method of sulfite limit in the gelatin hollow capsule shell of embodiment 3 comprises the following steps:
[0154] (1) Accurately weigh 246.9 mg of anhydrous potassium sulfite (equivalent to 100 mg of SO 2 ), put it in a 100ml measuring bottle, add purified water to dissolve and dilute to the mark, and shake up; accurately measure 1ml, put it in a 10ml measuring bottle, add purified water to dilute to the mark, shake up, and use it as a standard potassium sulfite solution (containing SO 2 The concentration is 100 μg / ml).
[0155] (2) Accurately weigh 2.0g of gelatin hollow capsule shell, add appropriate amount of water, shake fully, filter, put the filtrate in a 50ml Nessler colorimetric tube, add water to make 40ml, add 2ml of dilute hydrochloric acid, add 2ml of 30% hydrogen peroxide, Shake well to obtain the test solution.
[0156] (3) Take 2ml of standard potassium sulfite solution, put it in a 50ml Nessler colorimetric tube, add water to make about ...
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