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Traditional Chinese medicine compound for treating osteoporosis and preparation method thereof

A technology for osteoporosis and compound preparations, which is applied in medical formulas, medical preparations containing active ingredients, bone diseases, etc., can solve problems such as poor curative effect, adverse reactions of hormone replacement therapy, and decreased risk of vertebral fractures, achieving The effect of treating osteoporosis

Inactive Publication Date: 2016-07-13
LUOYANG ORTHOPEDIC TRAUMATOLOGICAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) Hormone replacement therapy Hormone replacement therapy is considered to be the best choice and the most effective treatment for postmenopausal women with osteoporosis. The problem is that hormone replacement therapy may cause adverse reactions in other systems
Such drugs include raloxifene, which is a non-steroidal benzothiophene and is an agonist of estrogen, which can inhibit bone resorption, increase the BMD of the spine and hip, and reduce the risk of vertebral fractures by 40% to 50%. , but less effective than estrogen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of active ingredient extract

[0032] Herbal formula:

[0033] Ligustrum lucidum, 60 parts; Da Ji, 40 parts; Atractylodes macrocephala, 25 parts; Guizhi, 20 parts; Sanqi, 25 parts; Eucommia, 40 parts; The ratio of the two parts by weight is 4:1.

[0034] Preparation method: take the crude drug in the prescribed amount and extract it with 80% ethanol under hot reflux for 2 to 3 times, combine the extracts, concentrate to a density of 1.25, and spray dry to obtain the extract powder. Each gram of the extract powder is equivalent to 4g of the crude drug.

Embodiment 2

[0035] Embodiment 2: the preparation of active ingredient extract

[0036] Herbal formula:

[0037] Ligustrum lucidum, 55 parts; Da Ji, 35 parts; Atractylodes macrocephala, 20 parts; Guizhi, 15 parts; Panax notoginseng, 20 parts; Eucommia, 35 parts; The ratio of the two parts by weight is 3:1.

[0038] Preparation method: Take the crude drug in the prescribed amount and extract it with 70% ethanol under hot reflux for 2 to 3 times, combine the extracts, concentrate to a density of 1.15, and spray dry to obtain the extract powder. Each gram of the extract powder is equivalent to 3g of the crude drug.

Embodiment 3

[0039] Embodiment 3: the preparation of active ingredient extract

[0040] Herbal formula:

[0041]Ligustrum lucidum, 65 parts; Da Ji, 45 parts; Atractylodes macrocephala, 30 parts; Guizhi, 25 parts; Sanqi, 30 parts; Eucommia, 45 parts; The ratio of the two parts by weight is 5:1.

[0042] Preparation method: extract the crude drug in the prescribed amount with 90% ethanol under hot reflux for 2 to 3 times, combine the extracts, concentrate to a density of 1.35, and spray dry to obtain extract powder. Each gram of extract powder is equivalent to 5g of crude drug.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine compound for treating osteoporosis and a preparation method thereof.The traditional Chinese medicine compound is prepared from, by weight, 55-65 parts of glossy privet fruit, 35-45 parts of herba cirsii japonici, 20-30 parts of rhizoma atractylodis macrocephalae, 15-25 parts of cassia twigs, 20-30 parts of radix notoginseng, 35-45 parts of cortex eucommiae, 5-15 parts of fructus citrus sarcodactylis and 40-60 parts of albizia flowers and herba epimedii, wherein the weight ratio of albizia flowers to herba epimedii is (3-5):1.Pharmacology experiments prove that the traditional Chinese medicine compound can treat the osteoporosis; traditional Chinese medicine active ingredient extract is prepared by extracting and concentrating the traditional Chinese medicine compound and can significantly treat the osteoporosis; a traditional Chinese medicine compound preparation contains the traditional Chinese medicine active ingredient extract and pharmaceutically acceptable auxiliary material carriers and can be used for treating the osteoporosis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines and relates to a compound traditional Chinese medicine, in particular to a compound traditional Chinese medicine for treating osteoporosis and a preparation method thereof. Background technique [0002] Osteoporosis is a bone disease characterized by decreased bone mass and microstructural deterioration of bone tissue, resulting in increased bone fragility. Osteoporosis is caused by a variety of reasons. Bone tissue has normal calcification, and the ratio of calcium salt to matrix is ​​normal. It is a metabolic bone lesion characterized by a decrease in the amount of bone tissue per unit volume. In most cases of osteoporosis, the loss of bone tissue is mainly due to increased bone resorption. Characterized by bone pain and susceptibility to fractures. [0003] The most common symptom of primary osteoporosis is low back pain, accounting for 70% to 80% of pain patients. The pain sprea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P19/10
CPCA61K36/752A61K36/258A61K36/28A61K36/284A61K36/296A61K36/46A61K36/48A61K36/54A61K36/638
Inventor 王一方张云芳孙实宁桃丽张丽殷娜许蒙蒙郭梦萍
Owner LUOYANG ORTHOPEDIC TRAUMATOLOGICAL HOSPITAL
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