Pharmaceutic preparation for treating lung cancer and application of pharmaceutic preparation

A pharmaceutical preparation, a technology for lung cancer, applied in the field of medicine, can solve the problems of unsatisfactory use and curative effect, unable to grasp the root cause, difficult to cure, etc., and achieve the effects of good therapeutic effect, low cost, and no toxic and side effects

Inactive Publication Date: 2016-07-13
王剑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, various cancers are often frequently-occurring, but it is extremely difficult to cure, and it seriously endangers people's health and life safety. The medical field is working hard to solve this problem. Because the parts of the cancer are different, they are called different cancers, such as Cancer that occurs in the intestine is called intestinal cancer, cancer that occurs in the liver is called liver cancer, and cancer that occurs in the lungs is called lung cancer. This application is a traditional Chinese medicine developed for lung cancer. Lung cancer is currently the leading cancer in the world. The number one cause of death, there are many medicines for the treatment of lung cancer at present, but due to various reasons, their use and curative effect are not satisfactory. Deficiency of external righteousness and excess of evil, deficiency of righteousness leads to low level of anti-evil mechanism, resulting in a susceptible body; excess of evil includes visible accumulation of poison, phlegm, and blood stasis, which accumulate in the lungs and form lung cancer Therefore, the method of treatment should adopt strengthening the body, dispelling pathogens, promoting blood circulation and removing blood stasis, and detoxifying to treat the symptoms. Traditional Chinese medicine is an effective drug for the treatment of lung cancer. The principles of traditional Chinese medicine and how to develop new drugs for the treatment of lung cancer are technical problems that need to be seriously solved by those skilled in the art

Method used

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  • Pharmaceutic preparation for treating lung cancer and application of pharmaceutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1: animal model test

[0085] In the existing therapeutic field, the inventor retrieved and found that the combined use of fluorouracil + vincristine + cyclophosphamide in mice is a better western medicine treatment method. This animal experiment uses it as a drug for the treatment of lung cancer in mice. Invented positive control test group.

[0086] Urethane is an anesthetic that can be used to induce the occurrence of lung cancer. It is often used as an inducer in animal models of lung cancer. Therefore, the present invention uses urethane as an inducer.

[0087] 1.1. Animal model establishment and administration

[0088] Female Kunming mice, 18-22g, 50, received intraperitoneal injection of urethane 800mg / kg twice a week for 5 consecutive weeks. Mice are divided into 5 groups at random, every group of 10: model group, positive control test I group (0.1mg+0.05mg+0.1mg), Chinese medicine composition high dose group (8g / kg), Chinese medicine composition mi...

Embodiment 2

[0110] Embodiment 2: clinical trial

[0111] 2.1. General Information

[0112] From 2013 to 2015, our hospital received a total of 88 lung cancer patients, who were divided into two groups, namely the experimental group and the observation group. The conditions of the two groups were basically the same, and there were significant differences in age and gender (P>0.05).

[0113] 2.2. Judgment criteria

[0114] Patients may be asymptomatic in the early stage, and most of them are found during chest X-ray examination. After tumor enlargement, cough, sputum, bloody sputum or a small amount of hemoptysis often occur, and secondary infection may have purulent sputum, fever, Loss of appetite, emaciation, etc., when there is a chest X-ray examination, it is found that there is a mass in the lungs, and often cough, expectoration, blood in the sputum or a small amount of hemoptysis, secondary infection may have purulent sputum, and fever, Those with symptoms of loss of appetite and we...

Embodiment 3

[0132] Example 3: Toxicity Verification

[0133] 3.1. Acute toxicity test

[0134] Tested Chinese medicine preparation: the capsules produced in Examples 4-7 of the present invention were added with purified water at a ratio of 1:2 to make a solution for later use. Experimental animals: normal grade Kunming mice, weighing 20g±5g, male and female, all female mice are sterile.

[0135] Mice gavaged the solution prepared by Chinese medicine capsules of the present invention, when the gavage dose reached 735.5g crude drug / kg dose, the mice showed a slight activity reduction after administration, and returned to normal in about 1 hour, and observed continuously for 7 days after administration. None of the animals died, and their general condition, diet, water intake, urination and weight gain were normal.

[0136] The test results showed that the maximum dosage of the capsules produced in Examples 4-7 was 735.5 g crude drug / kg / d (LD50>735.5 g crude drug / kg). The total amount of ...

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Abstract

The invention relates to a pharmaceutic preparation for treating lung cancer and an application of pharmaceutic preparation. The pharmaceutic preparation comprises 5-10 parts of lindley eupatorium herb, 10-25 parts of folium mori, 10-30 parts of muskmelon seeds, 5-9 parts of yerbadetajo herb, 4-10 parts of aleppo avens, 3-8 parts of rhizoma polygonati, 4-11 parts of deer-horn glue, 10-16 parts of astragalus membranaceus, 3-8 parts of cattail pollen, 5-11 parts of piper cubeba, 5-12 parts of herba eupatorii, 4-15 parts of chlorite schist, 10-20 parts of commelina communis, 8-17 parts of radix peucedani, 8-14 parts of liquorice, 5-14 parts of ovateleaf holly bark, 3-10 parts of cane shoots and 10-25 parts of fructus arctii. The pharmaceutic preparation lays emphasis on the theory of traditional Chinese medicine, selects the traditional Chinese medicine materials to be united to consolidate the symptoms, remove the root causes, restore the good and remove the evil, has both assistant and guide, enables the yin and yang to be balanced, lays emphasis on the function coordination of the internal organs such as kidney, heart, liver and spleen, and has the effects of activating blood to promote menstruation, relieving swelling and pain, regulating qi-flowing for strengthening the spleen, and inhibiting the tumor growth; by adding the traditional Chinese medicines such as astragalus membranaceus and herba eupatorii with qi tonifying and blood replenishing effects, the pharmaceutic preparation can be used for prolonging the survival time of patients and improving the life quality of the patients.

Description

technical field [0001] The invention relates to a drug for treating lung cancer and its use, in particular to a drug preparation for treating lung cancer and its use, and belongs to the field of medicine. Background technique [0002] In recent years, irrational eating habits and food safety issues have become increasingly prominent, and the prevalence of lung cancer has increased significantly all over the world. Lung cancer is one of the most common cancers, and the type of lung cancer depends on which type of cells are attacked. There are two basic types of lung cancer, the first is non-small cell lung cancer, and the other is small cell lung cancer, but clinically, lung cancer is divided into four types. [0003] Squamous cell carcinoma (also known as squamous cell carcinoma) is the most common among various types of lung cancer, accounting for about 50%. The age of patients is mostly over 50 years old, and the majority is male. Most of them originate from the larger b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P35/00A61K33/26A61K35/32
CPCA61K36/28A61K9/2059A61K9/4866A61K33/26A61K35/32A61K36/185A61K36/23A61K36/42A61K36/481A61K36/484A61K36/54A61K36/605A61K36/73A61K36/88A61K36/8969A61K36/899A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 王键
Owner 王剑
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